SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zl6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		5 / 12 THR A 208
HIS A 211
GLU A 212
HIS A 215
GLU A 250
 None
ZN  A 422 ( 3.3A)
SO4  A 500 (-2.4A)
ZN  A 422 ( 3.3A)
ZN  A 422 ( 2.4A)
 0.61A 1j36A-1zl6A:
2.0		 1j36A-1zl6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		5 / 12 THR A 208
HIS A 211
GLU A 212
HIS A 215
GLU A 250
 None
ZN  A 422 ( 3.3A)
SO4  A 500 (-2.4A)
ZN  A 422 ( 3.3A)
ZN  A 422 ( 2.4A)
 0.61A 1j36B-1zl6A:
2.1		 1j36B-1zl6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 PHE A 123
PHE A 302
SER A 129
ILE A 125
 None
 0.99A 1pnlA-1zl6A:
undetectable
1pnlB-1zl6A:
0.3		 1pnlA-1zl6A:
19.62
1pnlB-1zl6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 6 ILE A  85
VAL A  86
ILE A  47
ILE A 164
 None
 0.87A 1uwhB-1zl6A:
undetectable		 1uwhB-1zl6A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		5 / 8 GLY A 178
GLY A 222
GLY A 176
LEU A 274
ILE A 326
 None
 1.08A 1yajC-1zl6A:
undetectable		 1yajC-1zl6A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		6 / 12 ALA A 339
GLU A 335
LEU A 338
LEU A 207
ARG A 347
GLY A 373
 None
 1.42A 2jfaB-1zl6A:
undetectable		 2jfaB-1zl6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 6 LEU A 102
ASN A 163
LYS A 329
PHE A 333
 None
 0.99A 2jn3A-1zl6A:
undetectable		 2jn3A-1zl6A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		5 / 11 LEU A 103
LEU A 106
LEU A 220
ILE A  93
VAL A 183
 None
 1.14A 2qd3A-1zl6A:
undetectable		 2qd3A-1zl6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		3 / 3 ASN A 364
ASN A 361
ARG A  81
 None
 0.89A 2rlcA-1zl6A:
undetectable		 2rlcA-1zl6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 4 SER A 165
GLY A 176
GLY A 225
LYS A 224
 None
 1.37A 2y4nB-1zl6A:
0.1		 2y4nB-1zl6A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		3 / 3 TYR A 331
GLU A 249
ASN A 163
 None
 0.90A 2y7hC-1zl6A:
undetectable		 2y7hC-1zl6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 GLU A 250
HIS A 211
HIS A 215
GLU A 212
 ZN  A 422 ( 2.4A)
ZN  A 422 ( 3.3A)
ZN  A 422 ( 3.3A)
SO4  A 500 (-2.4A)
 0.95A 3a6jA-1zl6A:
undetectable		 3a6jA-1zl6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 7 GLU A 250
HIS A 211
HIS A 215
GLU A 212
 ZN  A 422 ( 2.4A)
ZN  A 422 ( 3.3A)
ZN  A 422 ( 3.3A)
SO4  A 500 (-2.4A)
 0.93A 3a6jB-1zl6A:
undetectable		 3a6jB-1zl6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 GLU A 250
HIS A 211
HIS A 215
GLU A 212
 ZN  A 422 ( 2.4A)
ZN  A 422 ( 3.3A)
ZN  A 422 ( 3.3A)
SO4  A 500 (-2.4A)
 0.93A 3a6jC-1zl6A:
undetectable		 3a6jC-1zl6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 GLU A 250
HIS A 211
HIS A 215
GLU A 212
 ZN  A 422 ( 2.4A)
ZN  A 422 ( 3.3A)
ZN  A 422 ( 3.3A)
SO4  A 500 (-2.4A)
 0.96A 3a6jE-1zl6A:
undetectable		 3a6jE-1zl6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 GLU A 250
HIS A 211
HIS A 215
GLU A 212
 ZN  A 422 ( 2.4A)
ZN  A 422 ( 3.3A)
ZN  A 422 ( 3.3A)
SO4  A 500 (-2.4A)
 0.93A 3a6jF-1zl6A:
undetectable		 3a6jF-1zl6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 6 TYR A  72
ARG A  81
PHE A  82
PHE A 185
 None
 1.38A 3af3A-1zl6A:
0.0		 3af3A-1zl6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		3 / 3 HIS A 211
GLU A 212
HIS A 215
 ZN  A 422 ( 3.3A)
SO4  A 500 (-2.4A)
ZN  A 422 ( 3.3A)
 0.15A 3kecB-1zl6A:
2.0		 3kecB-1zl6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 LEU A 274
VAL A 318
TYR A 306
LEU A 330
 None
 0.86A 3v81A-1zl6A:
undetectable		 3v81A-1zl6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 LEU A 274
VAL A 318
TYR A 306
LEU A 330
 None
 0.91A 3v81C-1zl6A:
undetectable		 3v81C-1zl6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 6 PHE A 327
ALA A 223
THR A 227
LEU A 252
 None
 0.99A 4ejgD-1zl6A:
undetectable		 4ejgD-1zl6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		5 / 12 LEU A 103
LEU A 106
LEU A 220
ILE A  93
VAL A 183
 None
 1.19A 4f4dA-1zl6A:
undetectable		 4f4dA-1zl6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		3 / 3 GLU A 153
ASP A 155
ASP A  53
 None
 0.76A 4gc9A-1zl6A:
undetectable		 4gc9A-1zl6A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 5 TYR A 368
ILE A 367
ASN A 375
ILE A 394
 None
 1.04A 4jtpA-1zl6A:
undetectable		 4jtpA-1zl6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		5 / 8 LEU A 103
LEU A 106
LEU A 220
ILE A  93
VAL A 183
 None
 1.24A 4klaA-1zl6A:
undetectable		 4klaA-1zl6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		5 / 9 LEU A 359
ILE A  89
ILE A  85
PHE A 342
GLY A 373
 None
 1.03A 4kukA-1zl6A:
undetectable		 4kukA-1zl6A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 6 ASP A 116
ASN A 117
TYR A 112
ASP A 277
 None
 1.20A 4mdaA-1zl6A:
undetectable		 4mdaA-1zl6A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 6 LEU A 259
HIS A 215
HIS A 211
GLU A 250
 None
ZN  A 422 ( 3.3A)
ZN  A 422 ( 3.3A)
ZN  A 422 ( 2.4A)
 1.10A 4pahA-1zl6A:
undetectable		 4pahA-1zl6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 LEU A 274
VAL A 318
TYR A 306
LEU A 330
 None
 0.78A 4puoC-1zl6A:
undetectable		 4puoC-1zl6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 LEU A 274
VAL A 318
TYR A 306
LEU A 330
 None
 0.83A 4pwdA-1zl6A:
undetectable		 4pwdA-1zl6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 LEU A 274
VAL A 318
TYR A 306
LEU A 330
 None
 0.89A 4pwdC-1zl6A:
undetectable		 4pwdC-1zl6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		3 / 3 LEU A 274
ASP A 277
TYR A 278
 None
 0.64A 4qc6B-1zl6A:
undetectable		 4qc6B-1zl6A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		5 / 10 LEU A 252
LEU A 259
TYR A 331
SER A 332
ILE A 262
 None
 0.98A 4xj7C-1zl6A:
undetectable
4xj7D-1zl6A:
undetectable		 4xj7C-1zl6A:
19.48
4xj7D-1zl6A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 TYR A 278
GLY A 176
ILE A 180
GLY A 219
 None
 0.81A 5alcL-1zl6A:
undetectable		 5alcL-1zl6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 GLU A 188
SER A 186
GLY A 151
TYR A  67
 None
 0.99A 5flcB-1zl6A:
0.0		 5flcB-1zl6A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 8 GLU A 188
SER A 186
GLY A 151
TYR A  67
 None
 0.99A 5flcF-1zl6A:
1.1		 5flcF-1zl6A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 4 LEU A 362
ASP A 204
PRO A 205
ARG A  92
 None
 0.95A 6fgdA-1zl6A:
undetectable		 6fgdA-1zl6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1zl6 BOTULINUM NEUROTOXIN
TYPE E
(Clostridium
botulinum) 		4 / 5 THR A 231
THR A 253
HIS A 215
GLY A 225
 None
None
ZN  A 422 ( 3.3A)
None
 1.16A 6gbnC-1zl6A:
undetectable		 6gbnC-1zl6A:
19.66