SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zl9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 4 HIS A  67
LEU A 138
LEU A 150
LEU A 155
 None
 1.16A 1a4lD-1zl9A:
undetectable		 1a4lD-1zl9A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 ILE A 126
PHE A 127
TYR A  97
HIS A 165
LEU A 169
 None
 0.99A 1fm6X-1zl9A:
undetectable		 1fm6X-1zl9A:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 7 TRP A  39
LEU A  42
GLY A  51
LEU A  53
 GSH  A 501 (-4.1A)
None
None
GSH  A 501 (-4.5A)
 0.71A 1gtiA-1zl9A:
22.7		 1gtiA-1zl9A:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 SER A 145
PHE A 149
LEU A  79
LEU A 160
TYR A  24
 None
 1.27A 1p33A-1zl9A:
undetectable		 1p33A-1zl9A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 SER A 145
PHE A 149
LEU A  79
LEU A 160
TYR A  24
 None
 1.33A 1p33C-1zl9A:
undetectable		 1p33C-1zl9A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 PHE A   9
GLY A  13
GLY A  11
VAL A  17
PRO A  54
 GSH  A 501 (-4.7A)
None
None
None
GSH  A 501 (-4.5A)
 1.02A 2zulA-1zl9A:
undetectable		 2zulA-1zl9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 PHE A   9
GLY A  13
GLY A  11
VAL A  17
PRO A  54
 GSH  A 501 (-4.7A)
None
None
None
GSH  A 501 (-4.5A)
 1.03A 3dmfA-1zl9A:
undetectable		 3dmfA-1zl9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 PHE A   9
GLY A  13
GLY A  11
VAL A  17
PRO A  54
 GSH  A 501 (-4.7A)
None
None
None
GSH  A 501 (-4.5A)
 1.04A 3dmhA-1zl9A:
undetectable		 3dmhA-1zl9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 TYR A  97
ILE A 162
ILE A 158
TRP A 157
HIS A  67
 None
 1.18A 3l4wA-1zl9A:
undetectable		 3l4wA-1zl9A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		5 / 12 PHE A 134
LEU A 142
LEU A 138
TYR A 135
ALA A 184
 None
 1.06A 3vw7A-1zl9A:
undetectable		 3vw7A-1zl9A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 6 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.05A 4mi4A-1zl9A:
undetectable		 4mi4A-1zl9A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 7 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.03A 4mi4B-1zl9A:
undetectable
4mi4C-1zl9A:
undetectable		 4mi4B-1zl9A:
19.57
4mi4C-1zl9A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 7 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.04A 4mi4A-1zl9A:
undetectable
4mi4C-1zl9A:
undetectable		 4mi4A-1zl9A:
19.57
4mi4C-1zl9A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 8 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.07A 4mj8A-1zl9A:
undetectable
4mj8C-1zl9A:
undetectable		 4mj8A-1zl9A:
21.50
4mj8C-1zl9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 8 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.03A 4mj8B-1zl9A:
undetectable
4mj8C-1zl9A:
undetectable		 4mj8B-1zl9A:
21.50
4mj8C-1zl9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 7 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.19A 4mj8C-1zl9A:
undetectable		 4mj8C-1zl9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 6 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.23A 4r87H-1zl9A:
undetectable		 4r87H-1zl9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1zl9 GLUTATHIONE
S-TRANSFERASE 5
(Caenorhabditis
elegans) 		4 / 7 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.23A 4r87I-1zl9A:
undetectable		 4r87I-1zl9A:
21.50