SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zlm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_A_ACTA803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1zlm	OSTEOCLAST STIMULATING FACTOR 1 (Homo sapiens)	4 / 4	GLU A 30 PRO A 62 ILE A 61 LEU A 60	GLU A 30 ( 0.6A) PRO A 62 ( 1.1A) ILE A 61 ( 0.5A) LEU A 60 ( 0.6A)	1.17A	5m45A-1zlmA: undetectable	5m45A-1zlmA: 6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_D_ACTD803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1zlm	OSTEOCLAST STIMULATING FACTOR 1 (Homo sapiens)	4 / 4	GLU A 30 PRO A 62 ILE A 61 LEU A 60	GLU A 30 ( 0.6A) PRO A 62 ( 1.1A) ILE A 61 ( 0.5A) LEU A 60 ( 0.6A)	1.21A	5m45D-1zlmA: undetectable	5m45D-1zlmA: 6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_G_ACTG803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1zlm	OSTEOCLAST STIMULATING FACTOR 1 (Homo sapiens)	4 / 4	GLU A 30 PRO A 62 ILE A 61 LEU A 60	GLU A 30 ( 0.6A) PRO A 62 ( 1.1A) ILE A 61 ( 0.5A) LEU A 60 ( 0.6A)	1.15A	5m45G-1zlmA: undetectable	5m45G-1zlmA: 6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M45_J_ACTJ803_0 (ACETONE CARBOXYLASE ALPHA SUBUNIT)	1zlm	OSTEOCLAST STIMULATING FACTOR 1 (Homo sapiens)	4 / 4	GLU A 30 PRO A 62 ILE A 61 LEU A 60	GLU A 30 ( 0.6A) PRO A 62 ( 1.1A) ILE A 61 ( 0.5A) LEU A 60 ( 0.6A)	1.20A	5m45J-1zlmA: undetectable	5m45J-1zlmA: 6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_C_FK5C201_0 (PEPTIDYLPROLYL ISOMERASE)	1zlm	OSTEOCLAST STIMULATING FACTOR 1 (Homo sapiens)	4 / 4	ASP A 43 ILE A 61 PRO A 62 LEU A 60	ASP A 43 ( 0.6A) ILE A 61 ( 0.5A) PRO A 62 ( 1.1A) LEU A 60 ( 0.6A)	1.36A	6mkeB-1zlmA: undetectable	6mkeB-1zlmA: 15.58

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5M45_A_ACTA803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1zlm","OSTEOCLAST STIMULATING FACTOR 1","Homo sapiens",4,"GLU A  30;PRO A  62;ILE A  61;LEU A  60","GLU A  30 ( 0.6A);PRO A  62 ( 1.1A);ILE A  61 ( 0.5A);LEU A  60 ( 0.6A)","1.17A","5m45A-1zlmA:undetectable","5m45A-1zlmA:6.98"],["5M45_D_ACTD803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1zlm","OSTEOCLAST STIMULATING FACTOR 1","Homo sapiens",4,"GLU A  30;PRO A  62;ILE A  61;LEU A  60","GLU A  30 ( 0.6A);PRO A  62 ( 1.1A);ILE A  61 ( 0.5A);LEU A  60 ( 0.6A)","1.21A","5m45D-1zlmA:undetectable","5m45D-1zlmA:6.98"],["5M45_G_ACTG803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1zlm","OSTEOCLAST STIMULATING FACTOR 1","Homo sapiens",4,"GLU A  30;PRO A  62;ILE A  61;LEU A  60","GLU A  30 ( 0.6A);PRO A  62 ( 1.1A);ILE A  61 ( 0.5A);LEU A  60 ( 0.6A)","1.15A","5m45G-1zlmA:undetectable","5m45G-1zlmA:6.98"],["5M45_J_ACTJ803_0","ACETONE CARBOXYLASE ALPHA SUBUNIT","1zlm","OSTEOCLAST STIMULATING FACTOR 1","Homo sapiens",4,"GLU A  30;PRO A  62;ILE A  61;LEU A  60","GLU A  30 ( 0.6A);PRO A  62 ( 1.1A);ILE A  61 ( 0.5A);LEU A  60 ( 0.6A)","1.20A","5m45J-1zlmA:undetectable","5m45J-1zlmA:6.98"],["6MKE_C_FK5C201_0","PEPTIDYLPROLYL ISOMERASE","1zlm","OSTEOCLAST STIMULATING FACTOR 1","Homo sapiens",4,"ASP A  43;ILE A  61;PRO A  62;LEU A  60","ASP A  43 ( 0.6A);ILE A  61 ( 0.5A);PRO A  62 ( 1.1A);LEU A  60 ( 0.6A)","1.36A","6mkeB-1zlmA:undetectable","6mkeB-1zlmA:15.58"]]