SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zlp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		3 / 3 THR A 264
LEU A 268
LEU A 275
 None
 0.49A 1mz9C-1zlpA:
undetectable		 1mz9C-1zlpA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		5 / 11 LEU A 135
GLY A 111
THR A  85
VAL A  89
VAL A  88
 None
 1.20A 2a1nA-1zlpA:
undetectable		 2a1nA-1zlpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 7 ASP A 107
SER A  66
SER A 257
ASN A 231
 MG  A 401 (-2.7A)
None
GAQ  A 402 ( 3.8A)
GAQ  A 402 (-3.9A)
 1.12A 2cmlA-1zlpA:
undetectable		 2cmlA-1zlpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 8 ASP A 107
SER A  66
SER A 257
ASN A 231
 MG  A 401 (-2.7A)
None
GAQ  A 402 ( 3.8A)
GAQ  A 402 (-3.9A)
 1.12A 2cmlD-1zlpA:
undetectable		 2cmlD-1zlpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		3 / 3 LEU A  77
PRO A  78
LEU A  82
 None
 0.47A 2qd5B-1zlpA:
undetectable		 2qd5B-1zlpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 6 GLN A  47
ALA A 267
ALA A 263
THR A 259
 None
 1.01A 2xfhA-1zlpA:
undetectable		 2xfhA-1zlpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 8 ASP A 107
TYR A 262
TYR A  68
CYH A 144
 MG  A 401 (-2.7A)
None
GAQ  A 402 ( 4.4A)
GAQ  A 402 (-1.6A)
 1.24A 2xz5A-1zlpA:
undetectable
2xz5C-1zlpA:
undetectable		 2xz5A-1zlpA:
18.65
2xz5C-1zlpA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		3 / 3 LEU A  77
PRO A  78
LEU A  82
 None
 0.52A 3hcrA-1zlpA:
2.5		 3hcrA-1zlpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 5 TYR A 198
THR A 206
PHE A 207
LEU A 135
 None
 1.19A 3qelC-1zlpA:
undetectable		 3qelC-1zlpA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 8 ASP A  79
SER A  69
SER A  66
TYR A 262
 MG  A 401 (-3.8A)
None
None
None
 0.87A 3rodA-1zlpA:
undetectable		 3rodA-1zlpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 5 LEU A 135
GLY A 111
THR A  85
VAL A  88
 None
 1.08A 3wrkD-1zlpA:
undetectable		 3wrkD-1zlpA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		5 / 12 LEU A 135
GLY A 111
THR A  85
VAL A  89
VAL A  88
 None
 1.06A 4c9lB-1zlpA:
undetectable		 4c9lB-1zlpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		5 / 10 LEU A 135
GLY A 111
THR A  85
VAL A  89
VAL A  88
 None
 1.05A 4jx1B-1zlpA:
undetectable		 4jx1B-1zlpA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 7 ALA A 203
ARG A 193
GLY A 191
GLU A 190
 None
 0.88A 5btdA-1zlpA:
undetectable
5btdB-1zlpA:
undetectable
5btdC-1zlpA:
undetectable		 5btdA-1zlpA:
22.69
5btdB-1zlpA:
22.45
5btdC-1zlpA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 7 ALA A 203
ARG A 193
GLY A 191
GLU A 190
 None
 0.90A 5btdA-1zlpA:
undetectable
5btdC-1zlpA:
undetectable
5btdD-1zlpA:
undetectable		 5btdA-1zlpA:
22.69
5btdC-1zlpA:
22.69
5btdD-1zlpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 6 ALA A 203
ARG A 193
GLY A 191
GLU A 190
 None
 0.93A 5btgA-1zlpA:
undetectable
5btgB-1zlpA:
undetectable
5btgC-1zlpA:
undetectable		 5btgA-1zlpA:
22.69
5btgB-1zlpA:
22.45
5btgC-1zlpA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 7 ALA A 203
ARG A 193
GLY A 191
GLU A 190
 None
 0.88A 5btgA-1zlpA:
undetectable
5btgC-1zlpA:
undetectable
5btgD-1zlpA:
undetectable		 5btgA-1zlpA:
22.69
5btgC-1zlpA:
22.69
5btgD-1zlpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		5 / 9 LEU A 135
GLY A 111
THR A  85
VAL A  89
VAL A  88
 None
 1.23A 5cp4A-1zlpA:
undetectable		 5cp4A-1zlpA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 8 PHE A  80
PRO A  78
LEU A  83
LEU A  82
 None
 1.03A 5dzkd-1zlpA:
3.5
5dzkr-1zlpA:
undetectable		 5dzkd-1zlpA:
20.74
5dzkr-1zlpA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 7 ILE A 192
GLY A 191
LEU A 176
PHE A 134
 None
 0.82A 5hieB-1zlpA:
undetectable		 5hieB-1zlpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		5 / 10 ASP A 137
ALA A 163
ILE A 162
TYR A 198
VAL A 118
 None
 1.22A 5i6xA-1zlpA:
undetectable		 5i6xA-1zlpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		3 / 3 ARG A 193
HIS A 186
ARG A 194
 None
 0.76A 5iaoC-1zlpA:
undetectable		 5iaoC-1zlpA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		3 / 3 ARG A 193
HIS A 186
ARG A 194
 None
 0.75A 5iaoF-1zlpA:
undetectable		 5iaoF-1zlpA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		3 / 3 SER A 257
SER A  66
PHE A 207
 GAQ  A 402 ( 3.8A)
None
None
 0.97A 5mugA-1zlpA:
1.8		 5mugA-1zlpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 8 THR A 180
TYR A 198
THR A 206
ARG A 228
 None
 1.28A 5tzoA-1zlpA:
undetectable		 5tzoA-1zlpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 8 THR A 180
TYR A 198
THR A 206
ARG A 228
 None
 1.31A 5tzoB-1zlpA:
undetectable		 5tzoB-1zlpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		4 / 8 THR A 180
TYR A 198
THR A 206
ARG A 228
 None
 1.26A 5tzoC-1zlpA:
undetectable		 5tzoC-1zlpA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		5 / 12 LEU A  77
GLY A  67
ALA A  72
VAL A  89
PHE A 121
 None
MG  A 401 ( 4.3A)
None
None
None
 1.32A 5x6yA-1zlpA:
undetectable		 5x6yA-1zlpA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 1zlp PETAL DEATH PROTEIN
(Dianthus
caryophyllus) 		5 / 12 VAL A 261
LEU A 125
ARG A  94
PHE A 121
THR A  84
 None
 1.40A 6brdA-1zlpA:
undetectable		 6brdA-1zlpA:
12.85