SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zlr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.83A 1a7yA-1zlrA:
undetectable		 1a7yA-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.63A 1a7yB-1zlrA:
undetectable		 1a7yB-1zlrA:
4.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 8 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
 368  A 901 (-4.0A)
368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.44A 1aq7A-1zlrA:
33.5		 1aq7A-1zlrA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		6 / 9 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 368  A 901 (-2.8A)
368  A 901 (-3.7A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.32A 1bcuH-1zlrA:
35.6		 1bcuH-1zlrA:
37.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.58A 1dscC-1zlrA:
undetectable		 1dscC-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.75A 1dscC-1zlrA:
undetectable		 1dscC-1zlrA:
4.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 368  A 901 (-4.0A)
368  A 901 (-2.8A)
368  A 901 (-1.4A)
None
368  A 901 (-3.5A)
 0.28A 1dwcH-1zlrA:
34.9		 1dwcH-1zlrA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		6 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 368  A 901 (-4.0A)
368  A 901 (-2.8A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.43A 1etrH-1zlrA:
34.8		 1etrH-1zlrA:
37.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
 368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.43A 1f5lA-1zlrA:
35.2		 1f5lA-1zlrA:
34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.72A 1fjaC-1zlrA:
undetectable		 1fjaC-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.73A 1fjaD-1zlrA:
undetectable		 1fjaD-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 12 GLY A 196
LEU A  39
LEU A 106
ALA A 104
PHE A  59
 None
 1.01A 1gseB-1zlrA:
undetectable		 1gseB-1zlrA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 7 GLY A 216
ASP A 102
HIS A  57
ALA A  55
 368  A 901 (-3.6A)
None
368  A 901 (-4.0A)
None
 1.00A 1gxsA-1zlrA:
undetectable
1gxsB-1zlrA:
undetectable		 1gxsA-1zlrA:
22.02
1gxsB-1zlrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.86A 1i3wE-1zlrA:
undetectable		 1i3wE-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.83A 1i3wE-1zlrA:
undetectable		 1i3wE-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.77A 1i3wF-1zlrA:
undetectable		 1i3wF-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.85A 1i3wG-1zlrA:
undetectable		 1i3wG-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.73A 1i3wG-1zlrA:
undetectable		 1i3wG-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.76A 1i3wH-1zlrA:
undetectable		 1i3wH-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.79A 1mnvD-1zlrA:
undetectable		 1mnvD-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.76A 1mnvD-1zlrA:
undetectable		 1mnvD-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.80A 1ovfB-1zlrA:
undetectable		 1ovfB-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 6 GLY A 142
GLN A 156
VAL A 138
ALA A 190
 None
None
None
368  A 901 (-3.7A)
 0.80A 1p6kA-1zlrA:
undetectable		 1p6kA-1zlrA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.81A 1qfiA-1zlrA:
undetectable		 1qfiA-1zlrA:
4.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.27A 1tnlA-1zlrA:
33.7		 1tnlA-1zlrA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.83A 1unjF-1zlrA:
undetectable		 1unjF-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.81A 1unjL-1zlrA:
undetectable		 1unjL-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.78A 1unjL-1zlrA:
undetectable		 1unjL-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.77A 1unjR-1zlrA:
undetectable		 1unjR-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.75A 1unjR-1zlrA:
undetectable		 1unjR-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.85A 1unjW-1zlrA:
undetectable		 1unjW-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.78A 1unjX-1zlrA:
undetectable		 1unjX-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.80A 1unjX-1zlrA:
undetectable		 1unjX-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.86A 1unmE-1zlrA:
undetectable		 1unmE-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.83A 1unmE-1zlrA:
undetectable		 1unmE-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.72A 1unmF-1zlrA:
undetectable		 1unmF-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.73A 1unmF-1zlrA:
undetectable		 1unmF-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  37
THR A  36
PRO A  37
 None
 0.83A 209dC-1zlrA:
undetectable		 209dC-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 12 PHE A  59
TYR A  59
ALA A  55
ALA A 104
GLY A 196
 None
 1.21A 2igtC-1zlrA:
undetectable		 2igtC-1zlrA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.28A 2otvA-1zlrA:
33.9		 2otvA-1zlrA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 12 GLY A 142
GLY A  42
GLY A 197
ILE A  52
VAL A  31
 None
 1.01A 2oxtA-1zlrA:
undetectable		 2oxtA-1zlrA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		6 / 12 GLY A 142
GLY A  42
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
None
None
368  A 901 (-3.3A)
None
None
 1.40A 2oxtD-1zlrA:
undetectable		 2oxtD-1zlrA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		7 / 12 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 368  A 901 (-2.8A)
368  A 901 (-3.7A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
None
 0.37A 2p16A-1zlrA:
35.1		 2p16A-1zlrA:
34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
 368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.39A 2vinA-1zlrA:
10.2		 2vinA-1zlrA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		8 / 12 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 218
GLY A 226
TYR A 228
 368  A 901 (-2.8A)
368  A 901 (-3.7A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-4.3A)
368  A 901 (-3.5A)
None
 0.43A 2w26A-1zlrA:
35.0		 2w26A-1zlrA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.80A 316dC-1zlrA:
undetectable		 316dC-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 12 LEU A 106
LEU A 108
THR A 139
VAL A  67
PRO A 198
 None
 1.17A 3dcjA-1zlrA:
undetectable
3dcjB-1zlrA:
undetectable		 3dcjA-1zlrA:
22.44
3dcjB-1zlrA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 368  A 901 (-4.0A)
368  A 901 (-2.8A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.24A 3gy3A-1zlrA:
12.6		 3gy3A-1zlrA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 12 LYS A  16
GLY A 197
ILE A 212
ALA A  55
ASP A 194
 None
 1.07A 3nvkI-1zlrA:
undetectable		 3nvkI-1zlrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 12 ASP A 116
ILE A  77
ILE A  44
ALA A 115
TYR A 114
 None
 1.12A 3ohtA-1zlrA:
undetectable
3ohtB-1zlrA:
undetectable		 3ohtA-1zlrA:
20.80
3ohtB-1zlrA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 6 SER A 195
TRP A 215
GLY A 216
GLY A 226
 368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.19A 3rxfA-1zlrA:
13.7		 3rxfA-1zlrA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 TRP A 137
TRP A  27
THR A 139
 None
 1.46A 4bboB-1zlrA:
undetectable		 4bboB-1zlrA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 6 PHE A  59
ALA A 104
GLY A  42
LEU A 106
 None
 0.84A 4dubB-1zlrA:
undetectable		 4dubB-1zlrA:
17.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 189
ALA A 190
TRP A 215
GLY A 226
 368  A 901 (-4.0A)
368  A 901 (-2.8A)
368  A 901 (-3.7A)
None
368  A 901 (-3.5A)
 0.22A 4hfpD-1zlrA:
34.6		 4hfpD-1zlrA:
36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 THR A  36
PRO A  37
THR A  37
 None
 0.86A 4hivD-1zlrA:
undetectable		 4hivD-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 7 VAL A  59
ILE A  88
ILE A  90
ALA A 104
 None
 0.94A 4lv9B-1zlrA:
undetectable		 4lv9B-1zlrA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 12 HIS A  57
ALA A 190
TRP A 215
GLY A 216
GLY A 226
 368  A 901 (-4.0A)
368  A 901 (-3.7A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.93A 4rn6B-1zlrA:
29.1		 4rn6B-1zlrA:
36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		3 / 3 GLU A 202
LYS A 202
ASN A 202
 None
 0.93A 4y1dA-1zlrA:
undetectable
4y1dD-1zlrA:
undetectable		 4y1dA-1zlrA:
24.39
4y1dD-1zlrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 12 GLY A 211
VAL A 112
GLY A 196
THR A 213
LEU A 198
 None
 1.15A 5hg0A-1zlrA:
undetectable		 5hg0A-1zlrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 9 LEU A  53
GLY A 196
GLY A  41
LEU A 105
ALA A 104
 None
 0.93A 5o96A-1zlrA:
undetectable
5o96B-1zlrA:
undetectable		 5o96A-1zlrA:
22.73
5o96B-1zlrA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		5 / 9 VAL A 210
GLY A 184
TYR A 228
VAL A 163
PRO A 225
 None
 1.36A 5zniA-1zlrA:
undetectable		 5zniA-1zlrA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1zlr COAGULATION FACTOR
XI
(Homo
sapiens) 		4 / 8 GLN A 156
VAL A  17
ALA A 220
TYR A 184
 None
 0.89A 6cduD-1zlrA:
undetectable
6cduE-1zlrA:
undetectable		 6cduD-1zlrA:
19.75
6cduE-1zlrA:
19.75