SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		3 / 3 LEU A  14
LEU A 105
MET A 104
 None
 0.82A 2itzA-1zlyA:
undetectable		 2itzA-1zlyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  17
PHE A 177
LEU A  14
ILE A  82
VAL A  40
 None
 1.37A 2pnjB-1zlyA:
2.8		 2pnjB-1zlyA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		5 / 12 MET A  89
ILE A  91
LEU A  92
ASN A 106
VAL A 139
 None
DQB  A1301 (-3.5A)
DQB  A1301 (-4.4A)
DQB  A1301 (-3.6A)
DQB  A1301 (-4.3A)
 0.53A 3dcjA-1zlyA:
15.6
3dcjB-1zlyA:
29.4		 3dcjA-1zlyA:
37.07
3dcjB-1zlyA:
37.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		4 / 8 ILE A  91
LEU A  92
ASN A 106
VAL A 139
 DQB  A1301 (-3.5A)
DQB  A1301 (-4.4A)
DQB  A1301 (-3.6A)
DQB  A1301 (-4.3A)
 0.57A 3dcjB-1zlyA:
29.4		 3dcjB-1zlyA:
37.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ILE A 107
ASN A  13
GLU A 173
GLN A 123
 GRF  A1300 (-4.5A)
GRF  A1300 (-4.0A)
GRF  A1300 (-2.8A)
None
 1.12A 4g0vA-1zlyA:
2.7		 4g0vA-1zlyA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		5 / 10 ALA A  28
ILE A  82
VAL A 184
VAL A   5
VAL A   3
 None
 1.02A 4j5jB-1zlyA:
undetectable		 4j5jB-1zlyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 146
GLN A 147
ALA A 140
ASN A 194
ILE A 197
 None
 1.26A 4pb1A-1zlyA:
undetectable		 4pb1A-1zlyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A  30
ALA A  28
SER A  20
LEU A  17
LEU A 105
 None
 1.34A 4qztC-1zlyA:
undetectable		 4qztC-1zlyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ALA A 120
VAL A 169
GLU A 173
HIS A 108
 None
None
GRF  A1300 (-2.8A)
None
 1.06A 5ecnA-1zlyA:
undetectable		 5ecnA-1zlyA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		4 / 6 GLY A 133
THR A 132
VAL A 169
HIS A 108
 None
 1.06A 5ewuB-1zlyA:
undetectable		 5ewuB-1zlyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 107
ALA A  28
VAL A   3
GLY A 187
THR A 188
 GRF  A1300 (-4.5A)
None
None
None
None
 1.20A 5igiA-1zlyA:
undetectable		 5igiA-1zlyA:
23.28