SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		5 / 11 LEU A 165
VAL A 158
VAL A 232
GLY A 233
LEU A 114
 None
 1.45A 1jkhA-1zmoA:
1.1
1jkhB-1zmoA:
undetectable		 1jkhA-1zmoA:
18.44
1jkhB-1zmoA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		5 / 11 LEU A 113
LEU A  62
VAL A  77
GLY A  14
HIS A  31
 None
 1.42A 1y4lB-1zmoA:
undetectable		 1y4lB-1zmoA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		5 / 10 LEU A 165
VAL A 158
VAL A 232
GLY A 233
LEU A 114
 None
 1.43A 2hndA-1zmoA:
undetectable		 2hndA-1zmoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		5 / 10 LEU A 165
VAL A 158
VAL A 232
GLY A 233
LEU A 114
 None
 1.42A 2hnyA-1zmoA:
undetectable		 2hnyA-1zmoA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		5 / 10 LEU A 165
VAL A 158
VAL A 232
GLY A 233
LEU A 114
 None
 1.45A 3lp1A-1zmoA:
undetectable		 3lp1A-1zmoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		4 / 8 ILE A 130
LEU A 223
LYS A 138
PHE A 236
 None
 1.01A 3selX-1zmoA:
undetectable		 3selX-1zmoA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		4 / 6 PHE A 222
ARG A 227
LEU A 223
SER A 225
 None
 1.28A 3vlnA-1zmoA:
undetectable		 3vlnA-1zmoA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		5 / 11 ILE A 130
ALA A 174
SER A 166
ILE A 170
THR A 133
 None
 1.30A 4qi9C-1zmoA:
undetectable		 4qi9C-1zmoA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		5 / 12 SER A 134
ILE A 132
PHE A  12
PHE A 186
LEU A 197
 None
 1.27A 6a93A-1zmoA:
undetectable		 6a93A-1zmoA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		4 / 6 PHE A 235
GLY A 176
THR A 133
TYR A 147
 None
 1.14A 6ag0A-1zmoA:
undetectable		 6ag0A-1zmoA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		4 / 6 PHE A 235
GLY A 176
THR A 133
TYR A 147
 None
 1.17A 6ag0C-1zmoA:
undetectable		 6ag0C-1zmoA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1zmo HALOHYDRIN
DEHALOGENASE
(Arthrobacter
sp.
AD2) 		3 / 3 TYR A 173
ALA A 161
LEU A 165
 None
 0.66A 6ag0C-1zmoA:
undetectable		 6ag0C-1zmoA:
15.57