SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1znx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1znx GUANYLATE KINASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  37
VAL A 136
VAL A 138
LEU A 196
 None
 0.81A 1igxA-1znxA:
undetectable		 1igxA-1znxA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1znx GUANYLATE KINASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE A  77
LEU A  86
LEU A 102
 None
 0.49A 1mx1E-1znxA:
undetectable		 1mx1E-1znxA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1znx GUANYLATE KINASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  87
ALA A 135
THR A 137
SER A  27
 None
 0.97A 4ikkA-1znxA:
undetectable
4ikkB-1znxA:
undetectable		 4ikkA-1znxA:
22.44
4ikkB-1znxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1znx GUANYLATE KINASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 116
ILE A 118
VAL A 106
THR A 101
 None
None
None
5GP  A 300 ( 4.8A)
 0.76A 4xdtA-1znxA:
undetectable		 4xdtA-1znxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 1znx GUANYLATE KINASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A  27
VAL A 120
GLY A 124
ALA A 125
 None
None
5GP  A 300 ( 4.9A)
None
 1.09A 5k50A-1znxA:
2.1		 5k50A-1znxA:
21.65