SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zo1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		5 / 10 ASP I 482
ALA I 444
GLU I 448
VAL I 479
VAL I 433
 None
 1.42A 1hk5A-1zo1I:
undetectable		 1hk5A-1zo1I:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		5 / 11 ILE I 384
ALA I 383
VAL I 330
VAL I 369
LEU I 244
 None
 1.24A 1n4hA-1zo1I:
undetectable		 1n4hA-1zo1I:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		4 / 8 GLY I 274
VAL I 269
GLU I 270
GLU I 389
 None
 0.85A 1pk7B-1zo1I:
2.9		 1pk7B-1zo1I:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		4 / 7 VAL I 422
GLY I 403
VAL I 433
ASP I 431
 None
 1.01A 1t88A-1zo1I:
undetectable		 1t88A-1zo1I:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.88A 2avsA-1zo1W:
undetectable		 2avsA-1zo1W:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
VAL W  68
 None
 0.74A 2avsA-1zo1W:
undetectable		 2avsA-1zo1W:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		3 / 3 ASP I 600
ILE I 611
VAL I 552
 None
 0.56A 2avvD-1zo1I:
undetectable		 2avvD-1zo1I:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		3 / 3 ASP I 711
ASP I 706
ASP I 669
 A  F  76 ( 3.8A)
None
None
 0.70A 2igtA-1zo1I:
undetectable		 2igtA-1zo1I:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		3 / 3 ASP I 711
ASP I 706
ASP I 669
 A  F  76 ( 3.8A)
None
None
 0.73A 2igtB-1zo1I:
undetectable		 2igtB-1zo1I:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		6 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
VAL W  68
 None
 1.05A 2o4lB-1zo1W:
undetectable		 2o4lB-1zo1W:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.91A 2pymB-1zo1W:
undetectable		 2pymB-1zo1W:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.89A 2pynB-1zo1W:
undetectable		 2pynB-1zo1W:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.89A 2q63A-1zo1W:
undetectable		 2q63A-1zo1W:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.89A 2q63B-1zo1W:
undetectable		 2q63B-1zo1W:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.89A 2q64A-1zo1W:
undetectable		 2q64A-1zo1W:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.90A 2qakB-1zo1W:
undetectable		 2qakB-1zo1W:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		4 / 8 GLY I 283
HIS I 284
ILE I 232
ALA I 539
 None
 0.64A 2x0pA-1zo1I:
undetectable		 2x0pA-1zo1I:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		4 / 6 GLU I 524
ALA I 574
ASN I 576
ALA I 573
 None
 1.14A 2zgwB-1zo1I:
undetectable		 2zgwB-1zo1I:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		4 / 4 LEU I 303
GLN I 314
THR I 315
THR I 231
 None
 1.47A 2zj0D-1zo1I:
undetectable		 2zj0D-1zo1I:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		4 / 8 THR W   9
GLY W  11
LEU W  26
ILE W  32
 None
 0.91A 3nbqC-1zo1W:
undetectable		 3nbqC-1zo1W:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 9 LEU W  26
GLY W  65
ALA W  34
VAL W  13
VAL W  68
 None
 0.84A 3oxvC-1zo1W:
undetectable		 3oxvC-1zo1W:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 10 LEU W  26
GLY W  65
ALA W  34
VAL W  13
VAL W  68
 None
 0.93A 3oxwA-1zo1W:
undetectable		 3oxwA-1zo1W:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 10 LEU W  26
ALA W  34
VAL W  13
ILE W  47
VAL W  68
 None
 1.04A 3oxwB-1zo1W:
undetectable		 3oxwB-1zo1W:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.92A 3oxxA-1zo1W:
undetectable		 3oxxA-1zo1W:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		4 / 4 LEU I 467
GLY I 466
LEU I 454
GLU I 455
 None
 0.96A 3tgvB-1zo1I:
undetectable		 3tgvB-1zo1I:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.88A 3tkgD-1zo1W:
undetectable		 3tkgD-1zo1W:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		5 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
 None
 0.88A 3tl9B-1zo1W:
undetectable		 3tl9B-1zo1W:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		5 / 12 LEU I 454
GLY I 466
GLN I 451
ARG I 414
ILE I 460
 None
 1.09A 4ok1A-1zo1I:
undetectable		 4ok1A-1zo1I:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		5 / 12 LEU I 454
GLY I 466
GLN I 451
ARG I 414
ILE I 460
 None
 1.12A 4okbA-1zo1I:
undetectable		 4okbA-1zo1I:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		5 / 12 LEU I 454
GLY I 466
GLN I 451
ARG I 414
ILE I 460
 None
 1.13A 4okwA-1zo1I:
undetectable		 4okwA-1zo1I:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		4 / 6 GLY I 457
PRO I 458
GLU I 455
SER I 468
 None
 0.71A 5ny7A-1zo1I:
undetectable		 5ny7A-1zo1I:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		4 / 4 VAL I 453
LEU I 454
LEU I 465
ASP I 411
 None
 1.01A 5xv7A-1zo1I:
undetectable		 5xv7A-1zo1I:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 1zo1 TRANSLATION
INITIATION FACTOR 1
(Escherichia
coli) 		6 / 12 LEU W  26
GLY W  65
ALA W  34
VAL W  13
ILE W  47
VAL W  68
 None
 0.90A 6dh6A-1zo1W:
undetectable		 6dh6A-1zo1W:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1zo1 TRANSLATION
INITIATION FACTOR 2
(Escherichia
coli) 		3 / 3 TYR I 353
HIS I 368
PHE I 366
 None
 0.90A 6esmA-1zo1I:
undetectable		 6esmA-1zo1I:
9.70