SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		5 / 9 ALA A 103
ASP A  76
GLY A  72
ILE A  71
VAL A  21
 None
 1.15A 1hpvB-1zofA:
undetectable		 1hpvB-1zofA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		4 / 5 LYS A   5
PHE A  10
LEU A   6
LEU A 116
 None
 1.39A 1skxA-1zofA:
0.0		 1skxA-1zofA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		4 / 6 LEU A  31
LEU A  27
PRO A 100
VAL A 102
 None
 1.16A 2dqyC-1zofA:
undetectable		 2dqyC-1zofA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		4 / 6 ASP A 104
PHE A  40
ASP A 112
TYR A 113
 None
 1.22A 2todA-1zofA:
0.1
2todB-1zofA:
0.0		 2todA-1zofA:
20.09
2todB-1zofA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		4 / 5 ASP A 112
TYR A 113
ASP A 104
PHE A  40
 None
 1.25A 2todA-1zofA:
0.1
2todB-1zofA:
0.1		 2todA-1zofA:
20.09
2todB-1zofA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_C_DMOC700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		4 / 5 ASP A 104
PHE A  40
ASP A 112
TYR A 113
 None
 1.25A 2todC-1zofA:
0.0
2todD-1zofA:
0.1		 2todC-1zofA:
20.09
2todD-1zofA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_D_DMOD700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		4 / 5 ASP A 112
TYR A 113
ASP A 104
PHE A  40
 None
 1.24A 2todC-1zofA:
0.0
2todD-1zofA:
0.1		 2todC-1zofA:
20.09
2todD-1zofA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		5 / 12 PHE A  63
VAL A  70
VAL A 156
VAL A  97
ILE A  53
 None
 1.19A 3dl9A-1zofA:
undetectable		 3dl9A-1zofA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		3 / 3 GLY A 146
ILE A 140
VAL A 139
 None
 0.45A 3nv6A-1zofA:
undetectable		 3nv6A-1zofA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1zof ALKYL
HYDROPEROXIDE-REDUCT
ASE
(Helicobacter
pylori) 		3 / 3 ARG A 111
LEU A 116
PHE A 117
 None
 0.74A 6nknP-1zofA:
undetectable		 6nknP-1zofA:
18.48