SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zor'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1zor ISOCITRATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 ASP A 228
ILE A 185
PRO A 293
ILE A 193
 None
 0.83A 1n49D-1zorA:
undetectable		 1n49D-1zorA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 1zor ISOCITRATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 THR A 321
PHE A 387
VAL A 306
GLY A 284
GLU A 300
 None
 1.25A 2w98A-1zorA:
undetectable		 2w98A-1zorA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1zor ISOCITRATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.88A 3vqrA-1zorA:
undetectable		 3vqrA-1zorA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1zor ISOCITRATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.89A 3vqrB-1zorA:
undetectable		 3vqrB-1zorA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1zor ISOCITRATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 ILE A 276
GLY A 131
ALA A 263
ALA A 249
ILE A 246
 None
 0.94A 4nkxB-1zorA:
undetectable		 4nkxB-1zorA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 1zor ISOCITRATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 ILE A 203
PHE A 108
SER A 191
ALA A 196
 None
 0.99A 5msdA-1zorA:
undetectable		 5msdA-1zorA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_B_ACTB302_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 1zor ISOCITRATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 GLU A  17
TYR A 310
TYR A  86
ARG A  82
 None
 1.44A 5mthA-1zorA:
0.0
5mthB-1zorA:
0.0		 5mthA-1zorA:
18.32
5mthB-1zorA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 1zor ISOCITRATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 GLU A  17
TYR A 310
TYR A  86
ARG A  82
 None
 1.41A 5mthH-1zorA:
0.0
5mthL-1zorA:
0.0		 5mthH-1zorA:
18.32
5mthL-1zorA:
18.87