SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A29_A_TFPA153_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		6 / 8 ILE B 100
LEU B 105
MET B 124
ALA B 128
VAL B 136
MET B 144
 None
None
None
None
CA  B 800 ( 4.9A)
None
 0.48A 1a29A-1zotB:
12.8		 1a29A-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		6 / 9 ILE B 100
LEU B 105
MET B 124
ALA B 128
VAL B 136
MET B 144
 None
None
None
None
CA  B 800 ( 4.9A)
None
 0.64A 1ctrA-1zotB:
12.5		 1ctrA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 9 ILE B 100
LEU B 105
MET B 124
GLU B 127
ALA B 128
 None
 1.09A 1ctrA-1zotB:
12.5		 1ctrA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 1zot CALMODULIN
(Homo
sapiens) 		7 / 11 PHE B  92
ILE B 100
LEU B 105
MET B 109
LEU B 112
MET B 124
MET B 144
 None
 0.72A 1dtlA-1zotB:
11.4		 1dtlA-1zotB:
30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA154_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 7 MET B 109
GLU B 114
LEU B 116
GLU B 120
MET B 124
 None
 0.98A 1linA-1zotB:
13.0		 1linA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA156_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 8 ILE B 100
LEU B 105
MET B 124
ILE B 125
GLU B 127
 None
 0.96A 1linA-1zotB:
13.0		 1linA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA156_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 8 ILE B 100
LEU B 105
MET B 124
ILE B 125
MET B 144
 None
 0.60A 1linA-1zotB:
13.0		 1linA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zot CALMODULIN
(Homo
sapiens) 		8 / 12 ILE B 100
LEU B 105
MET B 109
LEU B 112
GLU B 127
VAL B 136
MET B 144
MET B 145
 None
None
None
None
None
CA  B 800 ( 4.9A)
None
None
 1.06A 1lxfC-1zotB:
8.7		 1lxfC-1zotB:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zot CALMODULIN
(Homo
sapiens) 		9 / 12 PHE B  92
ILE B 100
LEU B 105
MET B 109
LEU B 112
ILE B 125
GLU B 127
VAL B 136
MET B 145
 None
None
None
None
None
None
None
CA  B 800 ( 4.9A)
None
 1.11A 1lxfC-1zotB:
8.7		 1lxfC-1zotB:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zot CALMODULIN
(Homo
sapiens) 		9 / 12 PHE B  92
ILE B 100
LEU B 105
MET B 109
LEU B 112
MET B 124
ILE B 125
VAL B 136
MET B 145
 None
None
None
None
None
None
None
CA  B 800 ( 4.9A)
None
 1.17A 1lxfC-1zotB:
8.7		 1lxfC-1zotB:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zot CALMODULIN
(Homo
sapiens) 		7 / 12 PHE B  92
ILE B 100
LEU B 105
MET B 124
ILE B 125
VAL B 136
MET B 144
 None
None
None
None
None
CA  B 800 ( 4.9A)
None
 1.16A 1lxfC-1zotB:
8.7		 1lxfC-1zotB:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zot CALMODULIN
(Homo
sapiens) 		4 / 6 VAL B 108
LEU B 112
PHE B 141
MET B 145
 None
 0.61A 1wrlB-1zotB:
10.0		 1wrlB-1zotB:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 10 MET B 109
LEU B 112
GLU B 120
MET B 124
MET B 145
 None
 0.87A 1wrlE-1zotB:
9.8
1wrlF-1zotB:
9.9		 1wrlE-1zotB:
38.55
1wrlF-1zotB:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KUH_A_HLTA150_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		4 / 6 LEU B 105
MET B 109
LEU B 116
MET B 124
 None
 1.10A 2kuhA-1zotB:
7.8		 2kuhA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		4 / 8 ILE B 100
LEU B 105
MET B 109
MET B 144
 None
 0.67A 4rjdA-1zotB:
13.0		 4rjdA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		4 / 8 ILE B 100
LEU B 105
MET B 109
VAL B 136
 None
None
None
CA  B 800 ( 4.9A)
 0.34A 4rjdA-1zotB:
13.0		 4rjdA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 8 ILE B 100
LEU B 105
MET B 124
ALA B 128
VAL B 136
 None
None
None
None
CA  B 800 ( 4.9A)
 0.36A 4rjdA-1zotB:
13.0		 4rjdA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 8 PHE B  92
ILE B 100
LEU B 105
MET B 124
VAL B 136
 None
None
None
None
CA  B 800 ( 4.9A)
 0.52A 4rjdA-1zotB:
13.0		 4rjdA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 7 LEU B 105
MET B 109
ALA B 128
MET B 144
MET B 145
 None
 1.03A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 7 LEU B 105
MET B 124
ALA B 128
MET B 144
MET B 145
 None
 0.74A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 7 PHE B  92
LEU B 105
MET B 109
ALA B 128
MET B 144
 None
 0.99A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		4 / 7 PHE B  92
LEU B 105
MET B 109
MET B 144
 None
 0.92A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 1zot CALMODULIN
(Homo
sapiens) 		5 / 7 PHE B  92
LEU B 105
MET B 124
ALA B 128
MET B 144
 None
 0.79A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1zot CALMODULIN
(Homo
sapiens) 		4 / 6 TYR B 138
ARG B  90
ASP B  93
GLY B  98
 None
None
CA  B 801 (-3.0A)
None
 1.17A 5mraA-1zotB:
3.8
5mraB-1zotB:
3.6		 5mraA-1zotB:
16.77
5mraB-1zotB:
16.77