SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 LEU A  66
ARG A  48
ARG A  49
ARG A  44
 None
 1.37A 3ticA-1zpsA:
undetectable		 3ticA-1zpsA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ASN A  43
LEU A  23
GLY A  64
SER A  62
 None
 0.95A 4cp3A-1zpsA:
undetectable
4cp3B-1zpsA:
undetectable		 4cp3A-1zpsA:
20.89
4cp3B-1zpsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 TYR A  58
HIS A  16
ASP A  87
ASP A  85
GLY A  88
 None
CD  A2611 ( 4.5A)
CD  A2606 (-2.2A)
CD  A2607 ( 2.5A)
None
 1.18A 4qa0A-1zpsA:
undetectable		 4qa0A-1zpsA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 TYR A  58
HIS A  16
ASP A  87
ASP A  85
GLY A  88
 None
CD  A2611 ( 4.5A)
CD  A2606 (-2.2A)
CD  A2607 ( 2.5A)
None
 1.20A 4qa0B-1zpsA:
undetectable		 4qa0B-1zpsA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 TYR A  58
HIS A  16
ASP A  87
ASP A  85
GLY A  88
 None
CD  A2611 ( 4.5A)
CD  A2606 (-2.2A)
CD  A2607 ( 2.5A)
None
 1.18A 4qa2A-1zpsA:
undetectable		 4qa2A-1zpsA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 TYR A  58
HIS A  16
ASP A  87
ASP A  85
GLY A  88
 None
CD  A2611 ( 4.5A)
CD  A2606 (-2.2A)
CD  A2607 ( 2.5A)
None
 1.18A 4qa2B-1zpsA:
undetectable		 4qa2B-1zpsA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 GLN A  97
GLY A  54
THR A  55
ALA A  56
THR A  50
 None
 1.44A 4qvnH-1zpsA:
undetectable
4qvnI-1zpsA:
undetectable		 4qvnH-1zpsA:
21.12
4qvnI-1zpsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 GLN A  97
GLY A  54
THR A  55
ALA A  56
THR A  50
 None
 1.42A 4qwuH-1zpsA:
undetectable
4qwuI-1zpsA:
undetectable		 4qwuH-1zpsA:
21.12
4qwuI-1zpsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 GLN A  97
GLY A  54
THR A  55
ALA A  56
THR A  50
 None
 1.42A 4qwuV-1zpsA:
undetectable
4qwuW-1zpsA:
undetectable		 4qwuV-1zpsA:
21.12
4qwuW-1zpsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 1zps PHOSPHORIBOSYL-AMP
CYCLOHYDROLASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 ARG A 107
GLY A 100
ALA A 101
GLY A 105
 None
 0.91A 4u9uB-1zpsA:
undetectable		 4u9uB-1zpsA:
17.73