SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 12 GLY A 386
ALA A 385
GLY A 379
ILE A 334
ILE A 350
 None
 0.92A 1hshC-1zq1A:
undetectable		 1hshC-1zq1A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		5 / 12 ILE C 242
ILE C 254
GLN C 246
ARG C 412
GLU C 258
 None
 1.35A 1ki3A-1zq1C:
0.0		 1ki3A-1zq1C:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		5 / 12 ILE C 242
ILE C 254
GLN C 246
ARG C 412
GLU C 258
 None
 1.32A 1ki7B-1zq1C:
undetectable		 1ki7B-1zq1C:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		4 / 8 ARG C 412
GLY C 334
GLU C 410
ILE C 323
 None
 0.80A 1pk7B-1zq1C:
undetectable		 1pk7B-1zq1C:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		4 / 4 VAL C 289
ALA C 313
LEU C 373
PHE C 379
 None
 0.83A 1q97B-1zq1C:
0.5		 1q97B-1zq1C:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		3 / 3 GLN C 106
LYS C 217
VAL C 219
 None
 0.92A 2jfaB-1zq1C:
undetectable		 2jfaB-1zq1C:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		5 / 12 ILE C 242
ILE C 254
GLN C 246
ARG C 412
GLU C 258
 None
 1.31A 2ki5A-1zq1C:
0.0		 2ki5A-1zq1C:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 7 ARG A  10
ILE A  59
PHE A   6
GLU A  62
 None
 1.26A 2nsiA-1zq1A:
undetectable
2nsiB-1zq1A:
undetectable		 2nsiA-1zq1A:
20.42
2nsiB-1zq1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 7 PHE A   6
GLU A  62
ARG A  10
ILE A  59
 None
 1.30A 2nsiA-1zq1A:
undetectable
2nsiB-1zq1A:
undetectable		 2nsiA-1zq1A:
20.42
2nsiB-1zq1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 7 PHE A   6
GLU A  62
ARG A  10
ILE A  59
 None
 1.29A 2nsiC-1zq1A:
undetectable
2nsiD-1zq1A:
undetectable		 2nsiC-1zq1A:
20.42
2nsiD-1zq1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 12 SER A 208
GLY A 100
ALA A 175
GLY A 203
ALA A 204
 None
 0.77A 2nyuA-1zq1A:
undetectable		 2nyuA-1zq1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi;
Pyrococcus
abyssi) 		3 / 3 ARG C  48
SER A 212
TYR C  76
 None
 0.93A 2q2hA-1zq1C:
undetectable
2q2hB-1zq1C:
undetectable		 2q2hA-1zq1C:
11.06
2q2hB-1zq1C:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		3 / 3 ARG C 340
ARG C 412
PRO C 408
 None
 0.89A 2wljA-1zq1C:
undetectable		 2wljA-1zq1C:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		4 / 7 GLY C 418
ILE C 242
GLN C 246
LEU C 415
 None
 0.65A 2xrhA-1zq1C:
undetectable		 2xrhA-1zq1C:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi;
Pyrococcus
abyssi) 		3 / 3 MET A  36
GLU A  40
ASP C 437
 None
 1.10A 3a25A-1zq1A:
undetectable		 3a25A-1zq1A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 7 ARG A  10
ILE A  59
PHE A   6
GLU A  62
 None
 1.27A 3e7gA-1zq1A:
undetectable
3e7gB-1zq1A:
undetectable		 3e7gA-1zq1A:
21.06
3e7gB-1zq1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 7 PHE A   6
GLU A  62
ARG A  10
ILE A  59
 None
 1.28A 3e7gA-1zq1A:
undetectable
3e7gB-1zq1A:
undetectable		 3e7gA-1zq1A:
21.06
3e7gB-1zq1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 7 ARG A  10
ILE A  59
PHE A   6
GLU A  62
 None
 1.29A 3e7gC-1zq1A:
undetectable
3e7gD-1zq1A:
undetectable		 3e7gC-1zq1A:
21.06
3e7gD-1zq1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 10 ILE A 346
ILE A 347
GLY A 379
PRO A 389
VAL A 360
 None
 1.29A 3elzB-1zq1A:
undetectable		 3elzB-1zq1A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 11 ALA A 186
LEU A 201
VAL A 233
ILE A 157
THR A 252
 None
 1.34A 3fl9C-1zq1A:
undetectable		 3fl9C-1zq1A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		4 / 7 ARG A 210
ASP A 209
PHE C 135
ARG C 137
 None
 1.45A 3kivA-1zq1A:
undetectable		 3kivA-1zq1A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 8 THR A 342
GLY A 340
LEU A 382
LEU A 373
 None
 0.72A 3nbqB-1zq1A:
1.7		 3nbqB-1zq1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		4 / 8 PHE C 489
GLU C 457
TYR C 470
LEU C 472
 None
 1.15A 3rqwC-1zq1C:
undetectable
3rqwD-1zq1C:
undetectable		 3rqwC-1zq1C:
17.77
3rqwD-1zq1C:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 8 PHE A   6
GLU A  62
ARG A  10
ILE A  59
 None
 1.31A 4cx7A-1zq1A:
undetectable
4cx7B-1zq1A:
undetectable		 4cx7A-1zq1A:
20.42
4cx7B-1zq1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		5 / 12 GLY C 347
ASP C 339
ALA C 392
VAL C 396
PHE C 337
 None
 1.17A 4dx5B-1zq1C:
2.6		 4dx5B-1zq1C:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi;
Pyrococcus
abyssi) 		4 / 8 ILE A 220
ARG C  51
PRO A  92
VAL A 136
 None
 1.30A 4f4dB-1zq1A:
4.5		 4f4dB-1zq1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		3 / 3 ASP C 181
ARG C 179
ASP C 164
 None
 0.78A 4fp9A-1zq1C:
undetectable		 4fp9A-1zq1C:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		3 / 3 ASP C 181
ARG C 179
ASP C 164
 None
 0.77A 4fp9C-1zq1C:
undetectable		 4fp9C-1zq1C:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		3 / 3 ASP C 181
ARG C 179
ASP C 164
 None
 0.76A 4fp9F-1zq1C:
undetectable		 4fp9F-1zq1C:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		4 / 6 ASP C 229
GLY C  18
PRO C 157
THR C 158
 None
 0.97A 4l1aB-1zq1C:
undetectable		 4l1aB-1zq1C:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		6 / 10 THR C 192
ILE C 254
VAL C 245
ALA C 206
ALA C 202
ILE C 251
 None
 1.43A 4lbgA-1zq1C:
undetectable		 4lbgA-1zq1C:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		3 / 3 SER A 146
ASP A 179
GLN A 205
 ASP  A1000 (-2.2A)
ASP  A1000 (-3.6A)
None
 0.74A 4oltA-1zq1A:
undetectable
4oltB-1zq1A:
undetectable		 4oltA-1zq1A:
19.82
4oltB-1zq1A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		5 / 11 ILE C 305
ASP C 291
SER C 360
ILE C 359
ILE C 301
 None
 1.45A 4p68A-1zq1C:
undetectable		 4p68A-1zq1C:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		3 / 3 GLN A 205
SER A 146
ASP A 179
 None
ASP  A1000 (-2.2A)
ASP  A1000 (-3.6A)
 0.75A 4qwpA-1zq1A:
undetectable
4qwpB-1zq1A:
undetectable		 4qwpA-1zq1A:
20.05
4qwpB-1zq1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		4 / 6 GLU C 490
TYR C 466
LEU C 472
PHE C 489
 None
 1.12A 4twdI-1zq1C:
undetectable
4twdJ-1zq1C:
undetectable		 4twdI-1zq1C:
17.80
4twdJ-1zq1C:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		5 / 12 GLY C 347
ASP C 339
ALA C 392
VAL C 396
PHE C 337
 None
 1.17A 4u8vB-1zq1C:
2.2		 4u8vB-1zq1C:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		5 / 12 GLY C 347
ASP C 339
ALA C 392
VAL C 396
PHE C 337
 None
 1.16A 4u95B-1zq1C:
2.6		 4u95B-1zq1C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		3 / 3 LEU A 285
ASP A 270
ILE A 276
 None
 0.67A 4xi3D-1zq1A:
undetectable		 4xi3D-1zq1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		3 / 3 LEU A  61
ASP C 117
ILE A  12
 None
 0.65A 4xi3D-1zq1A:
undetectable		 4xi3D-1zq1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		5 / 12 ARG C 325
ASP C 352
GLY C 334
VAL C 396
LEU C 316
 None
 1.03A 4y8wB-1zq1C:
undetectable		 4y8wB-1zq1C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 11 HIS A 176
VAL A 174
LEU A 188
THR A 184
ALA A 187
 None
 1.40A 4ygfA-1zq1A:
undetectable		 4ygfA-1zq1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 11 HIS A 176
VAL A 174
LEU A 188
THR A 184
ALA A 187
 None
 1.41A 4ygfC-1zq1A:
undetectable		 4ygfC-1zq1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 11 HIS A 176
VAL A 174
LEU A 188
THR A 184
ALA A 187
 None
 1.41A 4ygfD-1zq1A:
undetectable		 4ygfD-1zq1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 12 HIS A 176
VAL A 174
LEU A 188
THR A 184
ALA A 187
 None
 1.44A 4yhaG-1zq1A:
undetectable		 4yhaG-1zq1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi;
Pyrococcus
abyssi) 		4 / 4 ARG C  48
HIS A 258
ALA A 264
GLU C  90
 None
 1.28A 5a06A-1zq1C:
0.6
5a06F-1zq1C:
0.2		 5a06A-1zq1C:
21.88
5a06F-1zq1C:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		3 / 3 ILE C 169
MET C  88
ASP C 181
 None
 0.84A 5h2uA-1zq1C:
undetectable		 5h2uA-1zq1C:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 6 ARG A 370
ASP A 270
GLY A 425
LYS A 253
 None
 1.39A 5hp1C-1zq1A:
undetectable		 5hp1C-1zq1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		3 / 3 PRO C 279
ARG C 401
GLU C 405
 None
 0.85A 5j6hA-1zq1C:
undetectable		 5j6hA-1zq1C:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 11 ILE A 334
ILE A 346
VAL A 358
VAL A 307
LEU A 324
 None
 1.45A 5jkwA-1zq1A:
undetectable		 5jkwA-1zq1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 9 HIS A 176
VAL A 174
LEU A 188
THR A 184
ALA A 187
 None
 1.44A 5tt3E-1zq1A:
undetectable		 5tt3E-1zq1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 6 VAL A 172
THR A  95
LEU A 192
GLU A 295
 None
 0.98A 5tudD-1zq1A:
undetectable		 5tudD-1zq1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 6 VAL A 172
THR A  95
LEU A 195
GLU A 229
 None
 0.90A 5tudD-1zq1A:
undetectable		 5tudD-1zq1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 5 VAL A 223
PRO A 198
GLY A 171
TYR A 170
 None
 1.36A 5x80A-1zq1A:
undetectable
5x80B-1zq1A:
undetectable		 5x80A-1zq1A:
16.67
5x80B-1zq1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 5 PRO A 198
GLY A 171
TYR A 170
VAL A 223
 None
 1.30A 5x80C-1zq1A:
undetectable
5x80D-1zq1A:
undetectable		 5x80C-1zq1A:
16.67
5x80D-1zq1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 7 ALA A 185
THR A 184
TYR A 183
VAL A 254
 None
 0.78A 6cduA-1zq1A:
undetectable
6cduE-1zq1A:
undetectable		 6cduA-1zq1A:
22.05
6cduE-1zq1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 8 VAL A 254
ALA A 185
THR A 184
TYR A 183
 None
 0.85A 6cduD-1zq1A:
undetectable
6cduE-1zq1A:
undetectable		 6cduD-1zq1A:
22.05
6cduE-1zq1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		4 / 7 VAL A 254
ALA A 185
THR A 184
TYR A 183
 None
 0.82A 6cduH-1zq1A:
undetectable
6cduI-1zq1A:
undetectable		 6cduH-1zq1A:
22.05
6cduI-1zq1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
(Pyrococcus
abyssi) 		5 / 10 GLY A  98
LEU A 141
THR A  95
VAL A 172
ALA A 164
 None
 0.97A 6czmA-1zq1A:
undetectable
6czmC-1zq1A:
2.0		 6czmA-1zq1A:
22.69
6czmC-1zq1A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E
(Pyrococcus
abyssi) 		4 / 8 ARG C 340
VAL C 380
ARG C 331
GLN C 328
 None
 0.99A 6fbvD-1zq1C:
0.5		 6fbvD-1zq1C:
21.52