SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 GLY A  64
GLY A  66
GLU A  85
LEU A  90
ASP A 113
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
0.59A 1jg2A-1zq9A:
8.6
1jg2A-1zq9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 11 GLY A  64
GLY A  66
GLU A  85
LEU A  90
ASP A 113
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
0.58A 1jg3A-1zq9A:
10.2
1jg3A-1zq9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 11 GLY A  64
GLY A  66
GLU A  85
LEU A  90
ASP A 113
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
0.57A 1jg3B-1zq9A:
9.0
1jg3B-1zq9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 8 GLU A  62
GLY A  64
GLU A  85
LEU A  90
None
SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-4.8A)
0.50A 1jg4A-1zq9A:
9.9
1jg4A-1zq9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 8 GLY A  64
GLU A  85
LEU A  90
ASP A 113
SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
0.48A 1jg4A-1zq9A:
9.9
1jg4A-1zq9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
9 / 12 GLU A  62
GLY A  64
GLY A  66
ASP A  87
LEU A  90
ASP A 113
ASN A 128
PRO A 130
ILE A 133
None
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
None
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
SAM  A4000 ( 4.5A)
0.95A 1qaoA-1zq9A:
23.3
1qaoA-1zq9A:
26.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
11 / 12 HIS A  37
ILE A  38
GLY A  66
LEU A  86
LEU A  90
ASP A 113
VAL A 114
PRO A 130
ILE A 133
MET A 154
SER A 204
SAM  A4000 (-4.9A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.2A)
SAM  A4000 (-3.7A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-3.9A)
SAM  A4000 (-4.1A)
SAM  A4000 ( 4.5A)
None
SAM  A4000 (-3.4A)
0.01A 1zq9A-1zq9A:
44.2
1zq9A-1zq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
3 / 3 GLY A  64
GLU A  85
ASN A 128
SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-2.7A)
0.01A 1zq9A-1zq9A:
44.2
1zq9A-1zq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
11 / 12 HIS A  37
GLY A  64
GLY A  66
LEU A  86
LEU A  90
ASP A 113
VAL A 114
ASN A 128
PRO A 130
ILE A 133
PHE A 196
SAM  A4000 (-4.9A)
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-3.7A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-3.9A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
SAM  A4000 ( 4.5A)
SAM  A4000 (-3.9A)
0.40A 1zq9B-1zq9A:
40.2
1zq9B-1zq9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
10 / 12 HIS A  37
GLY A  64
GLY A  66
LEU A  90
VAL A 114
ASN A 128
LEU A 129
PRO A 130
ILE A 133
PHE A 196
SAM  A4000 (-4.9A)
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.9A)
SAM  A4000 (-2.7A)
None
SAM  A4000 (-4.1A)
SAM  A4000 ( 4.5A)
SAM  A4000 (-3.9A)
0.67A 1zq9B-1zq9A:
40.2
1zq9B-1zq9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 GLY A  68
ASN A  69
LEU A  86
ASP A  87
ASP A 113
None
None
SAM  A4000 (-3.7A)
None
SAM  A4000 (-3.8A)
1.03A 2b9eA-1zq9A:
12.2
2b9eA-1zq9A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 PRO A 130
GLY A  66
THR A  67
GLU A  85
LEU A  86
SAM  A4000 (-4.1A)
SAM  A4000 (-3.2A)
None
SAM  A4000 (-2.8A)
SAM  A4000 (-3.7A)
0.82A 2zifA-1zq9A:
2.8
2zifA-1zq9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 GLY A  64
GLY A  66
VAL A 114
ASN A 128
PRO A 130
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-3.9A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
1.09A 3dmhA-1zq9A:
10.6
3dmhA-1zq9A:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
6 / 12 GLY A  66
GLU A  85
ASP A  87
ASP A 113
PRO A 130
ILE A 133
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
None
SAM  A4000 (-3.8A)
SAM  A4000 (-4.1A)
SAM  A4000 ( 4.5A)
0.77A 3fuuA-1zq9A:
25.3
3fuuA-1zq9A:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
7 / 12 VAL A  63
GLY A  64
GLY A  66
GLU A  85
ASP A  87
ASP A 113
ILE A 133
None
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
None
SAM  A4000 (-3.8A)
SAM  A4000 ( 4.5A)
0.58A 3fuuA-1zq9A:
25.3
3fuuA-1zq9A:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
9 / 11 GLY A  64
GLY A  66
GLU A  85
ASP A  87
LEU A  90
ASP A 113
ASN A 128
PRO A 130
ILE A 133
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
None
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
SAM  A4000 ( 4.5A)
0.85A 3grvA-1zq9A:
28.1
3grvA-1zq9A:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
9 / 12 LEU A  39
GLU A  62
GLY A  64
GLY A  66
GLU A  85
ASP A  87
LEU A  90
ASP A 113
ASN A 128
None
None
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
None
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-2.7A)
0.64A 3gryA-1zq9A:
27.8
3gryA-1zq9A:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
9 / 12 LEU A  39
GLY A  64
GLY A  66
GLU A  85
ASP A  87
LEU A  90
ASP A 113
ASN A 128
PRO A 130
None
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
None
SAM  A4000 (-4.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
0.91A 3gryA-1zq9A:
27.8
3gryA-1zq9A:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
3 / 3 VAL A 232
VAL A 247
SER A 244
None
0.73A 3n8xB-1zq9A:
undetectable
3n8xB-1zq9A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 GLY A  64
LEU A  86
ASP A 113
ASN A 128
PRO A 130
SAM  A4000 (-3.1A)
SAM  A4000 (-3.7A)
SAM  A4000 (-3.8A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
0.69A 3q87B-1zq9A:
12.8
3q87B-1zq9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
6 / 12 GLU A  62
GLY A  64
GLY A  66
THR A  67
ASP A 113
VAL A 114
None
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
None
SAM  A4000 (-3.8A)
SAM  A4000 (-3.9A)
0.64A 3sglA-1zq9A:
5.3
3sglA-1zq9A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 GLY A  66
ASP A  87
VAL A 114
ASN A 128
PRO A 130
SAM  A4000 (-3.2A)
None
SAM  A4000 (-3.9A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
0.83A 3v8vA-1zq9A:
13.3
3v8vA-1zq9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 11 ASP A  87
ASP A 113
VAL A 114
ASN A 128
PRO A 130
None
SAM  A4000 (-3.8A)
SAM  A4000 (-3.9A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
1.16A 3v8vB-1zq9A:
10.9
3v8vB-1zq9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 11 GLY A  66
ASP A  87
VAL A 114
ASN A 128
PRO A 130
SAM  A4000 (-3.2A)
None
SAM  A4000 (-3.9A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
0.92A 3v8vB-1zq9A:
10.9
3v8vB-1zq9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 6 PHE A 159
ILE A 133
PRO A 130
PHE A 155
None
SAM  A4000 ( 4.5A)
SAM  A4000 (-4.1A)
None
1.17A 4fgkA-1zq9A:
undetectable
4fgkA-1zq9A:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 LEU A  39
GLY A  64
GLY A  66
VAL A 114
PRO A 130
None
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-3.9A)
SAM  A4000 (-4.1A)
0.84A 4gc9A-1zq9A:
25.3
4gc9A-1zq9A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 LEU A  39
GLY A  64
VAL A 114
LEU A 129
PRO A 130
None
SAM  A4000 (-3.1A)
SAM  A4000 (-3.9A)
None
SAM  A4000 (-4.1A)
1.04A 4gc9A-1zq9A:
25.3
4gc9A-1zq9A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 LEU A  39
GLY A  66
VAL A 114
ASN A 128
PRO A 130
None
SAM  A4000 (-3.2A)
SAM  A4000 (-3.9A)
SAM  A4000 (-2.7A)
SAM  A4000 (-4.1A)
0.84A 4gc9A-1zq9A:
25.3
4gc9A-1zq9A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 LEU A  39
VAL A 114
ASN A 128
LEU A 129
PRO A 130
None
SAM  A4000 (-3.9A)
SAM  A4000 (-2.7A)
None
SAM  A4000 (-4.1A)
0.97A 4gc9A-1zq9A:
25.3
4gc9A-1zq9A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
3 / 3 GLU A  85
ASP A  87
ASP A 113
SAM  A4000 (-2.8A)
None
SAM  A4000 (-3.8A)
0.53A 4gc9A-1zq9A:
25.3
4gc9A-1zq9A:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 GLU A 222
LEU A 226
ILE A 295
ILE A 177
LEU A 182
None
1.29A 4j26B-1zq9A:
undetectable
4j26B-1zq9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 GLY A  64
GLY A  66
LEU A  86
ASP A 113
ILE A 133
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-3.7A)
SAM  A4000 (-3.8A)
SAM  A4000 ( 4.5A)
0.75A 4krhA-1zq9A:
12.9
4krhA-1zq9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 5 THR A 237
THR A 283
HIS A 303
LEU A 226
None
1.31A 5axaC-1zq9A:
3.2
5axaC-1zq9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 6 PHE A 159
SER A 205
HIS A 187
LEU A 161
None
1.27A 5dzke-1zq9A:
undetectable
5dzks-1zq9A:
undetectable
5dzke-1zq9A:
23.24
5dzks-1zq9A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 6 PHE A 159
SER A 205
HIS A 187
LEU A 161
None
1.24A 5dzkg-1zq9A:
undetectable
5dzku-1zq9A:
undetectable
5dzkg-1zq9A:
23.24
5dzku-1zq9A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 7 GLY A  64
GLY A  66
GLU A  85
ASP A 113
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
SAM  A4000 (-3.8A)
0.57A 5ergB-1zq9A:
13.7
5ergB-1zq9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 7 GLY A  64
GLU A  85
ASP A 113
ASN A 128
SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-2.7A)
0.86A 5mvsA-1zq9A:
11.2
5mvsA-1zq9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 8 GLY A  64
GLU A  85
ASP A 113
ASN A 128
SAM  A4000 (-3.1A)
SAM  A4000 (-2.8A)
SAM  A4000 (-3.8A)
SAM  A4000 (-2.7A)
0.83A 5mvsB-1zq9A:
11.2
5mvsB-1zq9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
4 / 7 THR A 230
LEU A 238
ILE A 276
PHE A 305
None
0.98A 5zsfA-1zq9A:
0.0
5zsfB-1zq9A:
1.2
5zsfA-1zq9A:
15.70
5zsfB-1zq9A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 10 GLY A  64
GLY A  66
GLU A  85
ASP A  87
ILE A 133
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
None
SAM  A4000 ( 4.5A)
1.15A 6exiA-1zq9A:
3.4
6exiA-1zq9A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 10 GLY A  64
GLY A  66
GLU A  85
ASP A  87
ILE A 133
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
None
SAM  A4000 ( 4.5A)
1.15A 6exiB-1zq9A:
3.4
6exiB-1zq9A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 GLY A  64
GLY A  66
GLU A  85
ASP A  87
ILE A 133
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
None
SAM  A4000 ( 4.5A)
1.16A 6exiC-1zq9A:
3.3
6exiD-1zq9A:
3.1
6exiC-1zq9A:
13.52
6exiD-1zq9A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 12 GLY A  64
GLY A  66
GLU A  85
ASP A  87
ILE A 133
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-2.8A)
None
SAM  A4000 ( 4.5A)
1.17A 6exiC-1zq9A:
3.3
6exiD-1zq9A:
3.2
6exiC-1zq9A:
13.52
6exiD-1zq9A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
5 / 11 LEU A  39
MET A  70
THR A  71
LEU A 153
MET A 154
None
1.49A 6hupA-1zq9A:
0.0
6hupB-1zq9A:
0.0
6hupA-1zq9A:
13.38
6hupB-1zq9A:
15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
6 / 12 GLU A  62
GLY A  64
GLY A  66
ASP A  87
LEU A  90
VAL A 114
None
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
None
SAM  A4000 (-4.8A)
SAM  A4000 (-3.9A)
0.62A 6iftA-1zq9A:
27.0
6iftA-1zq9A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo
sapiens)
6 / 12 LEU A  39
GLU A  62
GLY A  64
GLY A  66
LEU A  90
VAL A 114
None
None
SAM  A4000 (-3.1A)
SAM  A4000 (-3.2A)
SAM  A4000 (-4.8A)
SAM  A4000 (-3.9A)
0.58A 6iftA-1zq9A:
27.0
6iftA-1zq9A:
31.53