SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		6 / 12 ILE A 125
LEU A 104
PRO A 101
VAL A 100
LEU A  15
ILE A 116
 None
 1.39A 1df7A-1zrmA:
2.9		 1df7A-1zrmA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		4 / 6 PRO A 190
PHE A 138
LEU A 114
ILE A   7
 None
 1.17A 1sbrA-1zrmA:
undetectable
1sbrB-1zrmA:
undetectable		 1sbrA-1zrmA:
24.91
1sbrB-1zrmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		5 / 10 ALA A 175
LEU A 117
ILE A 171
LEU A 164
THR A  14
 None
 1.37A 1tdrB-1zrmA:
undetectable		 1tdrB-1zrmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		5 / 11 THR A 191
ALA A 184
GLY A   6
ALA A   8
SER A 169
 None
 1.17A 2f162-1zrmA:
undetectable		 2f162-1zrmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		5 / 11 THR A 191
ALA A 184
GLY A   6
ALA A   8
SER A 169
 None
 1.17A 2f16N-1zrmA:
undetectable		 2f16N-1zrmA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		4 / 7 LEU A 172
LEU A  15
LEU A 107
ILE A 116
 None
 1.03A 4okwA-1zrmA:
undetectable		 4okwA-1zrmA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		5 / 9 LYS A   5
ASP A 167
GLY A 165
LEU A 164
ALA A 160
 None
 1.13A 5dqfA-1zrmA:
3.4		 5dqfA-1zrmA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		5 / 11 ASP A 180
TYR A 157
VAL A 174
LEU A 172
PRO A 190
 None
 1.45A 5jdcA-1zrmA:
6.1
5jdcD-1zrmA:
5.7		 5jdcA-1zrmA:
22.00
5jdcD-1zrmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		4 / 6 PHE A 222
VAL A 174
LEU A 104
LEU A 107
 None
 0.96A 6e43C-1zrmA:
undetectable		 6e43C-1zrmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1zrm L-2-HALOACID
DEHALOGENASE
(Pseudomonas
sp.
YL) 		4 / 8 ASP A 145
SER A 143
TYR A  57
ASN A 119
 None
None
None
BUA  A 300 (-4.1A)
 1.10A 6giqL-1zrmA:
undetectable
6giqP-1zrmA:
undetectable
6giqT-1zrmA:
undetectable		 6giqL-1zrmA:
21.59
6giqP-1zrmA:
20.82
6giqT-1zrmA:
13.27