SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zrz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 272
VAL A 307
VAL A 326
ASN A 374
LEU A 376
THR A 386
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.4A)
BI1  A1000 (-3.9A)
None
BI1  A1000 (-4.8A)
BI1  A1000 (-3.2A)
BI1  A1000 (-4.5A)
 0.78A 1fmoE-1zrzA:
35.9		 1fmoE-1zrzA:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 11 LEU A 370
GLY A 431
VAL A 483
LEU A 484
LEU A 357
 None
 1.06A 1mx1A-1zrzA:
undetectable		 1mx1A-1zrzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		3 / 3 THR A 457
LEU A 461
VAL A 464
 None
 0.59A 1mz9E-1zrzA:
undetectable		 1mz9E-1zrzA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 12 LEU A 341
ALA A 346
LEU A 331
LEU A 430
LEU A 488
 None
 1.16A 1og5A-1zrzA:
undetectable		 1og5A-1zrzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 6 ILE A 251
VAL A 259
VAL A 296
ILE A 365
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-4.2A)
None
None
BI1  A1000 (-4.5A)
 0.94A 1uwhB-1zrzA:
22.6		 1uwhB-1zrzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 12 LEU A 372
TYR A 410
TRP A 428
SER A 442
ILE A 465
 None
 1.34A 2efjA-1zrzA:
undetectable		 2efjA-1zrzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		8 / 12 VAL A 259
LYS A 274
VAL A 307
VAL A 326
ASP A 330
ASN A 374
LEU A 376
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
BI1  A1000 (-4.4A)
BI1  A1000 (-3.9A)
BI1  A1000 (-4.3A)
None
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.94A 2eufB-1zrzA:
25.8		 2eufB-1zrzA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		3 / 3 VAL A 259
VAL A 322
ASP A 378
 BI1  A1000 (-4.2A)
None
None
 0.69A 2fumD-1zrzA:
24.8		 2fumD-1zrzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 TYR A 256
GLU A 293
TYR A 367
GLY A 389
 None
BI1  A1000 ( 4.9A)
None
None
 1.24A 2ha4B-1zrzA:
undetectable		 2ha4B-1zrzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 VAL A 425
SER A 424
GLU A 419
PRO A 413
 None
 1.07A 2v41E-1zrzA:
undetectable
2v41F-1zrzA:
undetectable		 2v41E-1zrzA:
21.31
2v41F-1zrzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		3 / 3 PHE A 513
SER A 486
LEU A 484
 None
 0.82A 2w1bA-1zrzA:
undetectable		 2w1bA-1zrzA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 11 LEU A 554
VAL A 262
VAL A 250
PHE A 245
LEU A 242
 TPO  A 555 ( 4.1A)
None
None
None
None
 1.48A 3m8pA-1zrzA:
1.1
3m8pB-1zrzA:
0.0		 3m8pA-1zrzA:
20.00
3m8pB-1zrzA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		3 / 3 LEU A 331
HIS A 334
MET A 335
 None
 0.59A 3thrD-1zrzA:
undetectable		 3thrD-1zrzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		6 / 11 VAL A 259
ALA A 272
LYS A 274
ASP A 330
LEU A 376
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 (-4.3A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.64A 4iaaA-1zrzA:
28.4		 4iaaA-1zrzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 9 VAL A 464
ILE A 465
GLU A 436
LEU A 484
LEU A 488
 None
 1.47A 4l1xB-1zrzA:
0.0		 4l1xB-1zrzA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 VAL A 259
ALA A 272
ASP A 330
LEU A 376
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.3A)
BI1  A1000 (-4.8A)
 0.63A 4l9iA-1zrzA:
12.9		 4l9iA-1zrzA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		6 / 12 LEU A 370
ILE A 353
PHE A 487
GLY A 431
LEU A 433
MET A 437
 None
 1.35A 4lmnA-1zrzA:
24.0		 4lmnA-1zrzA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 12 VAL A 262
ALA A 272
TYR A 271
GLY A 241
SER A 311
 None
BI1  A1000 (-3.4A)
None
None
None
 1.17A 4mmdB-1zrzA:
undetectable		 4mmdB-1zrzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 9 VAL A 262
ALA A 272
TYR A 271
GLY A 241
SER A 311
 None
BI1  A1000 (-3.4A)
None
None
None
 1.25A 4mmfA-1zrzA:
undetectable		 4mmfA-1zrzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 9 VAL A 262
ALA A 272
TYR A 271
GLY A 241
SER A 311
 None
BI1  A1000 (-3.4A)
None
None
None
 1.21A 4mmfB-1zrzA:
undetectable		 4mmfB-1zrzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 5 PHE A 513
PHE A 512
LEU A 488
PRO A 443
 None
 1.33A 4o8zA-1zrzA:
undetectable		 4o8zA-1zrzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		7 / 12 ILE A 251
ALA A 272
LYS A 274
GLU A 293
TYR A 325
LEU A 376
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 ( 4.9A)
BI1  A1000 (-4.2A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.85A 4qmnA-1zrzA:
28.6		 4qmnA-1zrzA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		6 / 12 ILE A 251
GLY A 252
VAL A 259
ALA A 272
TYR A 325
LEU A 376
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.6A)
BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.2A)
BI1  A1000 (-4.8A)
 0.67A 4qmzA-1zrzA:
21.5		 4qmzA-1zrzA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		6 / 10 ILE A 251
ALA A 272
LYS A 274
PHE A 321
VAL A 326
LEU A 376
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
None
BI1  A1000 (-3.9A)
BI1  A1000 (-4.8A)
 0.59A 4rz7A-1zrzA:
12.4		 4rz7A-1zrzA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 8 ILE A 251
VAL A 259
VAL A 296
ILE A 365
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-4.2A)
None
None
BI1  A1000 (-4.5A)
 0.95A 5hi2A-1zrzA:
22.4		 5hi2A-1zrzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 12 TRP A 427
LEU A 430
ILE A 383
GLU A 362
LEU A 385
 None
 1.33A 5ienA-1zrzA:
undetectable		 5ienA-1zrzA:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 GLY A 252
GLY A 254
SER A 255
LYS A 274
 BI1  A1000 (-3.6A)
None
None
BI1  A1000 (-3.5A)
 0.75A 5izfA-1zrzA:
30.6		 5izfA-1zrzA:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 GLY A 252
GLY A 254
VAL A 259
LYS A 274
 BI1  A1000 (-3.6A)
None
BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
 0.37A 5izjA-1zrzA:
36.8		 5izjA-1zrzA:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 GLY A 252
GLY A 254
VAL A 259
LYS A 274
 BI1  A1000 (-3.6A)
None
BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
 0.30A 5j5xA-1zrzA:
36.0		 5j5xA-1zrzA:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		7 / 12 ILE A 251
GLY A 252
VAL A 259
ALA A 272
LYS A 274
GLU A 293
TYR A 325
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.6A)
BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 ( 4.9A)
BI1  A1000 (-4.2A)
 0.56A 5mafA-1zrzA:
28.8		 5mafA-1zrzA:
10.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		7 / 10 VAL A 259
ALA A 272
VAL A 307
TYR A 325
VAL A 326
LEU A 376
THR A 386
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.4A)
BI1  A1000 (-4.2A)
BI1  A1000 (-3.9A)
BI1  A1000 (-4.8A)
BI1  A1000 (-3.2A)
 0.81A 5n3hA-1zrzA:
36.4		 5n3hA-1zrzA:
36.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 4 VAL A 259
LYS A 274
VAL A 307
ASN A 374
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
BI1  A1000 (-4.4A)
None
 0.85A 5vc3A-1zrzA:
25.2		 5vc3A-1zrzA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		3 / 3 LYS A 274
LEU A 376
ASP A 387
 BI1  A1000 (-3.5A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.93A 5zv2A-1zrzA:
12.1		 5zv2A-1zrzA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 9 VAL A 296
HIS A 295
LEU A 357
VAL A 425
 None
 0.91A 6c2mD-1zrzA:
0.0		 6c2mD-1zrzA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 12 LEU A 430
ILE A 507
VAL A 516
LEU A 360
ALA A 356
 None
 1.18A 6djzA-1zrzA:
undetectable		 6djzA-1zrzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 5 ILE A 353
SER A 354
ALA A 346
LEU A 331
 None
 1.06A 6dwnA-1zrzA:
undetectable		 6dwnA-1zrzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		7 / 12 VAL A 259
ALA A 272
LYS A 274
GLU A 293
VAL A 307
LEU A 376
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 ( 4.9A)
BI1  A1000 (-4.4A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 1.06A 6hd4A-1zrzA:
20.0		 6hd4A-1zrzA:
14.04