SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zs3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		3 / 3 PHE A  39
PHE A  72
PHE A  73
 None
 0.83A 2od9A-1zs3A:
undetectable		 2od9A-1zs3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		3 / 3 PHE A  39
PHE A  72
PHE A  73
 None
 0.83A 2qqgA-1zs3A:
undetectable		 2qqgA-1zs3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 7 TYR A  71
VAL A 149
TYR A 154
ILE A 129
 None
 1.34A 2xz5B-1zs3A:
undetectable
2xz5E-1zs3A:
undetectable		 2xz5B-1zs3A:
20.09
2xz5E-1zs3A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 8 ILE A 129
TYR A  71
VAL A 149
TYR A 154
 None
 1.30A 2xz5C-1zs3A:
undetectable
2xz5D-1zs3A:
undetectable		 2xz5C-1zs3A:
20.09
2xz5D-1zs3A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 7 ILE A 129
TYR A  71
VAL A 149
TYR A 154
 None
 1.31A 2xz5D-1zs3A:
undetectable
2xz5E-1zs3A:
undetectable		 2xz5D-1zs3A:
20.09
2xz5E-1zs3A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 7 ILE A  75
LEU A  38
ILE A 129
ASN A 155
 None
 0.78A 3p50A-1zs3A:
4.1		 3p50A-1zs3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 7 ILE A  75
LEU A  38
ILE A 129
ASN A 155
 None
 0.79A 3p50B-1zs3A:
4.1		 3p50B-1zs3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 7 ILE A  75
LEU A  38
ILE A 129
ASN A 155
 None
 0.79A 3p50C-1zs3A:
4.2		 3p50C-1zs3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 7 ILE A  75
LEU A  38
ILE A 129
ASN A 155
 None
 0.79A 3p50D-1zs3A:
4.1		 3p50D-1zs3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 7 ILE A  75
LEU A  38
ILE A 129
ASN A 155
 None
 0.79A 3p50E-1zs3A:
4.1		 3p50E-1zs3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 4 LYS A  98
GLU A 102
ILE A  40
SER A  36
 None
 1.42A 4ac9C-1zs3A:
undetectable		 4ac9C-1zs3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 4 LYS A  98
GLU A 102
ILE A  40
SER A  36
 None
 1.42A 4acaC-1zs3A:
undetectable		 4acaC-1zs3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 4 LYS A  98
GLU A 102
ILE A  40
SER A  36
 None
 1.37A 4acbC-1zs3A:
undetectable		 4acbC-1zs3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		4 / 7 SER A  36
TYR A  96
GLU A  92
PHE A  72
 None
 1.16A 5aclA-1zs3A:
undetectable		 5aclA-1zs3A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		5 / 12 PHE A  39
PHE A  93
VAL A  86
VAL A  69
PHE A  72
 None
 1.22A 6ap6A-1zs3A:
undetectable		 6ap6A-1zs3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		5 / 12 PHE A  39
PHE A  93
VAL A  86
VAL A  69
PHE A  72
 None
 1.21A 6ap6B-1zs3A:
undetectable		 6ap6B-1zs3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA
(Lactococcus
lactis) 		3 / 3 ASP A 111
LEU A 115
ARG A  44
 None
 0.90A 7dfrA-1zs3A:
undetectable		 7dfrA-1zs3A:
21.51