SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zs6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 6 MET A  85
VAL A  82
LEU A  81
PHE A  77
 None
None
ADP  A 201 (-4.1A)
ADP  A 201 (-3.5A)
 1.00A 1x8vA-1zs6A:
undetectable		 1x8vA-1zs6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 6 HIS A 135
GLU A 146
ASP A 138
SER A 142
 None
 1.26A 4apjA-1zs6A:
undetectable
4apjP-1zs6A:
undetectable		 4apjA-1zs6A:
14.34
4apjP-1zs6A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 6 GLY A 123
ARG A  35
GLU A  40
ARG A  44
 None
 1.15A 4bqfA-1zs6A:
undetectable		 4bqfA-1zs6A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 7 MET A  93
ILE A 134
ARG A 122
VAL A 100
 None
None
ADP  A 201 (-3.5A)
None
 1.38A 4f4dA-1zs6A:
undetectable		 4f4dA-1zs6A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 7 GLY A 136
ALA A 143
SER A 137
GLU A  22
 None
 0.88A 4hyfA-1zs6A:
undetectable		 4hyfA-1zs6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 8 GLY A 136
ALA A 143
SER A 137
GLU A  22
 None
 0.89A 4hyfB-1zs6A:
undetectable		 4hyfB-1zs6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 8 GLY A 136
ALA A 143
SER A 137
GLU A  22
 None
 0.90A 4hyfC-1zs6A:
undetectable		 4hyfC-1zs6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 5 SER A 137
ALA A 143
HIS A 135
LEU A  26
 None
 1.42A 5dzkb-1zs6A:
undetectable
5dzkp-1zs6A:
undetectable		 5dzkb-1zs6A:
21.68
5dzkp-1zs6A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 5 SER A 137
ALA A 143
HIS A 135
LEU A  26
 None
 1.40A 5dzkc-1zs6A:
undetectable
5dzkq-1zs6A:
undetectable		 5dzkc-1zs6A:
21.68
5dzkq-1zs6A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens) 		4 / 7 THR A 111
LEU A  26
VAL A  90
GLU A  40
 ADP  A 201 (-2.9A)
None
None
None
 1.10A 5tudA-1zs6A:
undetectable		 5tudA-1zs6A:
14.66