SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		4 / 5 GLN B  93
LEU B  54
TYR B  86
TYR B  57
 None
 1.23A 1yc2B-1zt2B:
0.0
1yc2C-1zt2B:
0.0		 1yc2B-1zt2B:
22.06
1yc2C-1zt2B:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		3 / 3 LYS B   7
VAL B  58
HIS B  56
 None
 1.23A 3tj7A-1zt2B:
undetectable		 3tj7A-1zt2B:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		4 / 7 LYS B 116
VAL B 140
TYR B 145
LEU B 178
 None
 1.03A 4b3qA-1zt2B:
undetectable		 4b3qA-1zt2B:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		4 / 8 THR B  70
TYR B  60
PRO B   9
TYR B  86
 None
 1.22A 5v4vA-1zt2B:
undetectable		 5v4vA-1zt2B:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		4 / 8 THR B  70
TYR B  60
PRO B   9
TYR B  86
 None
 1.22A 5v4vB-1zt2B:
undetectable		 5v4vB-1zt2B:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		4 / 6 GLU B  62
TYR B  21
GLY B  22
GLY B  23
 None
 0.94A 5x7pB-1zt2B:
undetectable		 5x7pB-1zt2B:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		5 / 10 LEU B  72
LEU B  18
ASP B  15
ILE B 199
PRO B 200
 None
None
None
None
SO4  B 218 (-4.0A)
 1.28A 6dlzB-1zt2B:
undetectable
6dlzC-1zt2B:
undetectable		 6dlzB-1zt2B:
15.08
6dlzC-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		5 / 11 ILE B 199
PRO B 200
LEU B  72
LEU B  18
ASP B  15
 None
SO4  B 218 (-4.0A)
None
None
None
 1.29A 6dlzA-1zt2B:
undetectable
6dlzD-1zt2B:
2.2		 6dlzA-1zt2B:
15.08
6dlzD-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		5 / 10 LEU B  72
LEU B  18
ASP B  15
ILE B 199
PRO B 200
 None
None
None
None
SO4  B 218 (-4.0A)
 1.29A 6dm0B-1zt2B:
2.2
6dm0C-1zt2B:
undetectable		 6dm0B-1zt2B:
15.08
6dm0C-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		5 / 10 LEU B  72
LEU B  18
ASP B  15
ILE B 199
PRO B 200
 None
None
None
None
SO4  B 218 (-4.0A)
 1.29A 6dm1B-1zt2B:
2.2
6dm1C-1zt2B:
undetectable		 6dm1B-1zt2B:
15.08
6dm1C-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		5 / 11 ILE B 199
PRO B 200
LEU B  72
LEU B  18
ASP B  15
 None
SO4  B 218 (-4.0A)
None
None
None
 1.29A 6dm1A-1zt2B:
undetectable
6dm1D-1zt2B:
2.2		 6dm1A-1zt2B:
15.08
6dm1D-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		5 / 10 LEU B  72
LEU B  18
ASP B  15
ILE B 199
PRO B 200
 None
None
None
None
SO4  B 218 (-4.0A)
 1.27A 6dm2B-1zt2B:
2.1
6dm2C-1zt2B:
undetectable		 6dm2B-1zt2B:
15.08
6dm2C-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		5 / 10 ILE B 199
PRO B 200
LEU B  72
LEU B  18
ASP B  15
 None
SO4  B 218 (-4.0A)
None
None
None
 1.27A 6dm2A-1zt2B:
undetectable
6dm2D-1zt2B:
2.2		 6dm2A-1zt2B:
15.08
6dm2D-1zt2B:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		4 / 4 GLN B  46
THR B  48
THR B  69
LEU B  77
 None
 1.47A 6f3mA-1zt2B:
undetectable		 6f3mA-1zt2B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 1zt2 DNA PRIMASE LARGE
SUBUNIT
(Sulfolobus
solfataricus) 		4 / 4 GLN B  46
THR B  48
THR B  69
LEU B  77
 None
 1.47A 6f3mC-1zt2B:
undetectable		 6f3mC-1zt2B:
21.60