SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ztc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		5 / 12 HIS A  74
HIS A  69
ASP A  73
HIS A  71
TYR A 108
 NI  A 301 (-3.4A)
NI  A 302 (-3.3A)
NI  A 301 (-3.2A)
NI  A 302 (-3.2A)
None
 1.46A 1t69A-1ztcA:
undetectable		 1t69A-1ztcA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		5 / 11 ASP A  73
HIS A  74
HIS A 140
ASP A 162
HIS A 199
 NI  A 301 (-3.2A)
NI  A 301 (-3.4A)
NI  A 302 (-3.4A)
NI  A 301 ( 2.3A)
NI  A 301 (-3.4A)
 0.38A 2q0jB-1ztcA:
15.3		 2q0jB-1ztcA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		4 / 6 LEU A 194
ILE A   5
ILE A  62
LEU A  66
 None
 0.93A 2xkwB-1ztcA:
undetectable		 2xkwB-1ztcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		5 / 9 PHE A  13
HIS A  71
ASP A  73
HIS A 140
HIS A 199
 None
NI  A 302 (-3.2A)
NI  A 301 (-3.2A)
NI  A 302 (-3.4A)
NI  A 301 (-3.4A)
 0.89A 4c1dA-1ztcA:
3.1		 4c1dA-1ztcA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		5 / 10 HIS A  69
HIS A  71
ASP A  73
HIS A 140
HIS A 199
 NI  A 302 (-3.3A)
NI  A 302 (-3.2A)
NI  A 301 (-3.2A)
NI  A 302 (-3.4A)
NI  A 301 (-3.4A)
 0.84A 4c1dB-1ztcA:
4.6		 4c1dB-1ztcA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		5 / 11 HIS A  69
HIS A  71
ASP A  73
HIS A 140
HIS A 199
 NI  A 302 (-3.3A)
NI  A 302 (-3.2A)
NI  A 301 (-3.2A)
NI  A 302 (-3.4A)
NI  A 301 (-3.4A)
 0.90A 4c1fA-1ztcA:
15.2
4c1fB-1ztcA:
15.1		 4c1fA-1ztcA:
23.58
4c1fB-1ztcA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		5 / 9 HIS A  69
HIS A  71
ASP A  73
HIS A 140
HIS A 199
 NI  A 302 (-3.3A)
NI  A 302 (-3.2A)
NI  A 301 (-3.2A)
NI  A 302 (-3.4A)
NI  A 301 (-3.4A)
 0.83A 4c1hA-1ztcA:
5.9		 4c1hA-1ztcA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		4 / 8 HIS A  71
ASP A  73
HIS A 140
HIS A 199
 NI  A 302 (-3.2A)
NI  A 301 (-3.2A)
NI  A 302 (-3.4A)
NI  A 301 (-3.4A)
 0.87A 4exsB-1ztcA:
14.1		 4exsB-1ztcA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		4 / 7 LEU A 195
VAL A 196
PRO A 198
TYR A 171
 None
 0.87A 4lb2A-1ztcA:
undetectable		 4lb2A-1ztcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		4 / 7 LEU A 195
VAL A 196
PRO A 198
TYR A 171
 None
 1.03A 4lb2A-1ztcA:
undetectable		 4lb2A-1ztcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		4 / 6 LEU A  66
MET A   1
LEU A 149
VAL A 189
 None
None
None
MPD  A 304 (-4.5A)
 1.16A 4okbA-1ztcA:
undetectable		 4okbA-1ztcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		5 / 11 HIS A  74
HIS A  69
ASP A  73
HIS A  71
TYR A 108
 NI  A 301 (-3.4A)
NI  A 302 (-3.3A)
NI  A 301 (-3.2A)
NI  A 302 (-3.2A)
None
 1.48A 4qa0B-1ztcA:
undetectable		 4qa0B-1ztcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		4 / 8 HIS A  71
ASP A  73
HIS A 140
HIS A 199
 NI  A 302 (-3.2A)
NI  A 301 (-3.2A)
NI  A 302 (-3.4A)
NI  A 301 (-3.4A)
 0.87A 5a5zA-1ztcA:
3.6		 5a5zA-1ztcA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		6 / 11 HIS A  69
HIS A  71
ASP A  73
HIS A  74
HIS A 140
HIS A 199
 NI  A 302 (-3.3A)
NI  A 302 (-3.2A)
NI  A 301 (-3.2A)
NI  A 301 (-3.4A)
NI  A 302 (-3.4A)
NI  A 301 (-3.4A)
 0.46A 5ayaA-1ztcA:
14.7		 5ayaA-1ztcA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		4 / 7 LEU A  80
SER A 114
ILE A 107
ASN A  41
 None
 0.82A 5n5dA-1ztcA:
undetectable		 5n5dA-1ztcA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		5 / 10 HIS A  69
HIS A  71
HIS A  74
HIS A 140
ASP A 162
 NI  A 302 (-3.3A)
NI  A 302 (-3.2A)
NI  A 301 (-3.4A)
NI  A 302 (-3.4A)
NI  A 301 ( 2.3A)
 0.32A 5nzwA-1ztcA:
2.1		 5nzwA-1ztcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		4 / 8 HIS A  71
ASP A  73
HIS A 140
HIS A 199
 NI  A 302 (-3.2A)
NI  A 301 (-3.2A)
NI  A 302 (-3.4A)
NI  A 301 (-3.4A)
 0.95A 5zj8A-1ztcA:
14.0		 5zj8A-1ztcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1ztc HYPOTHETICAL PROTEIN
TM0894
(Thermotoga
maritima) 		3 / 3 LEU A  42
ASP A  38
ILE A  36
 None
 0.57A 6dh0B-1ztcA:
undetectable		 6dh0B-1ztcA:
17.54