SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 8 ILE A 350
LEU A 324
ILE A 326
VAL A 335
ILE A 367
 None
 1.45A 1linA-1zu4A:
undetectable		 1linA-1zu4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 12 GLY A 203
GLY A 208
VAL A 344
VAL A 202
ARG A 236
 None
SO4  A1130 (-3.7A)
None
None
SO4  A1130 (-3.9A)
 1.28A 1n2xA-1zu4A:
undetectable		 1n2xA-1zu4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 1zu4 FTSY
(Mycoplasma
mycoides) 		3 / 3 ASN A 253
ALA A 221
ASN A 218
 None
 0.78A 1n4fA-1zu4A:
undetectable		 1n4fA-1zu4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 10 LEU A 388
ILE A 363
GLY A 361
VAL A 380
ILE A 378
 None
 0.84A 1sdtA-1zu4A:
undetectable		 1sdtA-1zu4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zu4 FTSY
(Mycoplasma
mycoides) 		4 / 7 LEU A 116
PHE A 403
PHE A 162
SER A 172
 None
 0.93A 1wrlE-1zu4A:
undetectable
1wrlF-1zu4A:
1.6		 1wrlE-1zu4A:
15.48
1wrlF-1zu4A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1zu4 FTSY
(Mycoplasma
mycoides) 		3 / 3 ASP A 190
ILE A 311
VAL A 202
 None
 0.51A 2avvD-1zu4A:
undetectable		 2avvD-1zu4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 12 LEU A 388
ILE A 363
GLY A 361
VAL A 380
ILE A 378
 None
 0.82A 2r5pA-1zu4A:
undetectable		 2r5pA-1zu4A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 12 LEU A 388
ILE A 363
GLY A 361
VAL A 380
ILE A 378
 None
 0.82A 2r5pC-1zu4A:
undetectable		 2r5pC-1zu4A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 12 LEU A 135
LEU A 169
ILE A 396
TYR A 395
PHE A 109
 None
 1.21A 2weyA-1zu4A:
undetectable		 2weyA-1zu4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1zu4 FTSY
(Mycoplasma
mycoides) 		3 / 3 GLY A 206
GLY A 208
THR A 210
 SO4  A1130 (-3.8A)
SO4  A1130 (-3.7A)
SO4  A1130 (-3.2A)
 0.37A 3si7B-1zu4A:
undetectable		 3si7B-1zu4A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 12 TYR A 395
ILE A 378
ILE A 326
THR A 138
ILE A 375
 None
 1.26A 3vrjA-1zu4A:
undetectable
3vrjC-1zu4A:
undetectable		 3vrjA-1zu4A:
19.19
3vrjC-1zu4A:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1zu4 FTSY
(Mycoplasma
mycoides) 		4 / 7 ILE A 326
LEU A 324
PHE A 341
GLY A 292
 None
 0.96A 4hajA-1zu4A:
undetectable		 4hajA-1zu4A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 1zu4 FTSY
(Mycoplasma
mycoides) 		4 / 7 LEU A 196
ALA A 230
LEU A 228
ILE A 288
 None
 0.85A 4ubsA-1zu4A:
undetectable		 4ubsA-1zu4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 12 LEU A 324
LEU A 352
THR A 329
ALA A 338
ILE A 363
 None
 1.01A 4x20B-1zu4A:
3.7		 4x20B-1zu4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 10 GLY A 334
ALA A 366
VAL A 335
ASP A 327
ILE A 326
 None
 1.15A 5i3cB-1zu4A:
undetectable		 5i3cB-1zu4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1zu4 FTSY
(Mycoplasma
mycoides) 		4 / 7 LEU A 228
ALA A 274
ILE A 198
LEU A 196
 None
 0.93A 5te8C-1zu4A:
undetectable		 5te8C-1zu4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1zu4 FTSY
(Mycoplasma
mycoides) 		4 / 6 ARG A 293
LEU A 300
ALA A 345
GLN A 295
 None
 1.03A 6b89B-1zu4A:
2.7		 6b89B-1zu4A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 1zu4 FTSY
(Mycoplasma
mycoides) 		5 / 10 PHE A 199
MET A 216
ALA A 217
THR A 249
VAL A 227
 None
 1.50A 6hu9C-1zu4A:
1.3		 6hu9C-1zu4A:
21.11