SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zvd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.42A 1d1vA-1zvdA:
0.0
1d1vB-1zvdA:
0.0		 1d1vA-1zvdA:
22.11
1d1vB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.44A 1d1vA-1zvdA:
0.0
1d1vB-1zvdA:
0.0		 1d1vA-1zvdA:
22.11
1d1vB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.44A 1d1wA-1zvdA:
0.0
1d1wB-1zvdA:
0.0		 1d1wA-1zvdA:
22.11
1d1wB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_B_H4BB601_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.46A 1d1wA-1zvdA:
0.0
1d1wB-1zvdA:
0.0		 1d1wA-1zvdA:
22.11
1d1wB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_A_H4BA600_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.41A 1d1xA-1zvdA:
0.0
1d1xB-1zvdA:
0.0		 1d1xA-1zvdA:
22.11
1d1xB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_B_H4BB601_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.47A 1d1xA-1zvdA:
0.0
1d1xB-1zvdA:
0.0		 1d1xA-1zvdA:
22.11
1d1xB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_A_H4BA1600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.43A 1dm8A-1zvdA:
0.0
1dm8B-1zvdA:
0.0		 1dm8A-1zvdA:
22.11
1dm8B-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_B_H4BB2600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.46A 1dm8A-1zvdA:
0.0
1dm8B-1zvdA:
0.0		 1dm8A-1zvdA:
22.11
1dm8B-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_A_H4BA1600_1
(NITRIC-OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.42A 1fopA-1zvdA:
0.0
1fopB-1zvdA:
0.0		 1fopA-1zvdA:
22.11
1fopB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 5 THR A 505
PHE A 504
GLU A 623
GLY A 502
 None
 1.32A 1icrA-1zvdA:
undetectable
1icrB-1zvdA:
undetectable		 1icrA-1zvdA:
18.06
1icrB-1zvdA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 5 GLU A 623
GLY A 502
THR A 505
PHE A 504
 None
 1.34A 1icrA-1zvdA:
undetectable
1icrB-1zvdA:
undetectable		 1icrA-1zvdA:
18.06
1icrB-1zvdA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 5 GLU A 623
GLY A 502
THR A 505
PHE A 504
 None
 1.26A 1kqbA-1zvdA:
undetectable
1kqbB-1zvdA:
undetectable		 1kqbA-1zvdA:
19.05
1kqbB-1zvdA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 1nseA-1zvdA:
0.0
1nseB-1zvdA:
0.0		 1nseA-1zvdA:
22.11
1nseB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.43A 1nseA-1zvdA:
0.0
1nseB-1zvdA:
0.0		 1nseA-1zvdA:
22.11
1nseB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.42A 1p6lA-1zvdA:
0.0
1p6lB-1zvdA:
0.0		 1p6lA-1zvdA:
22.86
1p6lB-1zvdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.45A 1p6lA-1zvdA:
0.0
1p6lB-1zvdA:
0.0		 1p6lA-1zvdA:
22.86
1p6lB-1zvdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.42A 1p6mA-1zvdA:
0.0
1p6mB-1zvdA:
0.0		 1p6mA-1zvdA:
22.86
1p6mB-1zvdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.39A 1p6nA-1zvdA:
0.0
1p6nB-1zvdA:
0.0		 1p6nA-1zvdA:
22.86
1p6nB-1zvdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.48A 1p6nA-1zvdA:
0.0
1p6nB-1zvdA:
0.0		 1p6nA-1zvdA:
22.86
1p6nB-1zvdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		3 / 3 VAL A 437
ALA A 438
HIS A 496
 None
 0.71A 1q23C-1zvdA:
undetectable		 1q23C-1zvdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		3 / 3 VAL A 437
ALA A 438
HIS A 496
 None
 0.66A 1q23L-1zvdA:
undetectable		 1q23L-1zvdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 1q2oA-1zvdA:
0.0
1q2oB-1zvdA:
0.0		 1q2oA-1zvdA:
22.91
1q2oB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.44A 1q2oA-1zvdA:
0.0
1q2oB-1zvdA:
0.0		 1q2oA-1zvdA:
22.91
1q2oB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.44A 1rs8A-1zvdA:
0.0
1rs8B-1zvdA:
0.0		 1rs8A-1zvdA:
22.91
1rs8B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.48A 1rs8A-1zvdA:
0.0
1rs8B-1zvdA:
0.0		 1rs8A-1zvdA:
22.91
1rs8B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.41A 1rs9A-1zvdA:
0.0
1rs9B-1zvdA:
0.0		 1rs9A-1zvdA:
22.91
1rs9B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.44A 1rs9A-1zvdA:
0.0
1rs9B-1zvdA:
0.0		 1rs9A-1zvdA:
22.91
1rs9B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 7 PHE A 656
LEU A 672
VAL A 675
ILE A 700
 None
 0.81A 1t87B-1zvdA:
undetectable		 1t87B-1zvdA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 1zzsA-1zvdA:
0.0
1zzsB-1zvdA:
0.0		 1zzsA-1zvdA:
22.91
1zzsB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.46A 1zzsA-1zvdA:
0.0
1zzsB-1zvdA:
0.0		 1zzsA-1zvdA:
22.91
1zzsB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 2hx2A-1zvdA:
0.0
2hx2B-1zvdA:
0.0		 2hx2A-1zvdA:
22.91
2hx2B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.44A 2hx2A-1zvdA:
0.0
2hx2B-1zvdA:
0.0		 2hx2A-1zvdA:
22.91
2hx2B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		5 / 9 ILE A 720
ILE A 722
PHE A 698
ALA A 659
LEU A 671
 None
 1.05A 2m9qA-1zvdA:
undetectable		 2m9qA-1zvdA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 508
PHE A 598
GLY A 487
GLY A 604
 None
 1.01A 2qr2A-1zvdA:
undetectable
2qr2B-1zvdA:
undetectable		 2qr2A-1zvdA:
21.28
2qr2B-1zvdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 5 GLY A 487
GLY A 604
PHE A 508
PHE A 598
 None
 1.06A 2qr2A-1zvdA:
undetectable
2qr2B-1zvdA:
undetectable		 2qr2A-1zvdA:
21.28
2qr2B-1zvdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.48A 3dqsA-1zvdA:
0.0
3dqsB-1zvdA:
0.0		 3dqsA-1zvdA:
22.91
3dqsB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 GLN A 385
LEU A 383
GLU A 382
LEU A 613
 None
 0.69A 3h5gA-1zvdA:
undetectable
3h5gC-1zvdA:
undetectable		 3h5gA-1zvdA:
6.10
3h5gC-1zvdA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.48A 3jwzA-1zvdA:
0.0
3jwzB-1zvdA:
0.0		 3jwzA-1zvdA:
22.11
3jwzB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Q_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.49A 3n5qA-1zvdA:
0.0
3n5qB-1zvdA:
0.0		 3n5qA-1zvdA:
22.11
3n5qB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.48A 3n5sA-1zvdA:
0.0
3n5sB-1zvdA:
0.0		 3n5sA-1zvdA:
22.11
3n5sB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.48A 3n5sA-1zvdA:
0.0
3n5sB-1zvdA:
0.0		 3n5sA-1zvdA:
22.11
3n5sB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 7 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 3n5tA-1zvdA:
undetectable
3n5tB-1zvdA:
undetectable		 3n5tA-1zvdA:
22.11
3n5tB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.47A 3n5tA-1zvdA:
0.0
3n5tB-1zvdA:
0.0		 3n5tA-1zvdA:
22.11
3n5tB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 3n61A-1zvdA:
undetectable
3n61B-1zvdA:
undetectable		 3n61A-1zvdA:
21.29
3n61B-1zvdA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.50A 3n6eA-1zvdA:
0.0
3n6eB-1zvdA:
0.0		 3n6eA-1zvdA:
22.11
3n6eB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.48A 3n6eA-1zvdA:
0.0
3n6eB-1zvdA:
0.0		 3n6eA-1zvdA:
22.11
3n6eB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_A_H4BA600_1
('NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.47A 3n6fA-1zvdA:
0.0
3n6fB-1zvdA:
0.0		 3n6fA-1zvdA:
22.11
3n6fB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_B_H4BB600_1
('NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.45A 3n6fA-1zvdA:
0.0
3n6fB-1zvdA:
0.0		 3n6fA-1zvdA:
22.11
3n6fB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.47A 3n6gA-1zvdA:
0.0
3n6gB-1zvdA:
0.0		 3n6gA-1zvdA:
22.11
3n6gB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.44A 3n6gA-1zvdA:
0.0
3n6gB-1zvdA:
0.0		 3n6gA-1zvdA:
22.11
3n6gB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.49A 3nlgA-1zvdA:
0.0
3nlgB-1zvdA:
0.0		 3nlgA-1zvdA:
22.11
3nlgB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.48A 3nlgA-1zvdA:
0.0
3nlgB-1zvdA:
0.0		 3nlgA-1zvdA:
22.11
3nlgB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		5 / 12 LEU A 442
LEU A 445
ILE A 500
ILE A 489
TYR A 459
 None
 1.14A 4a7aB-1zvdA:
undetectable		 4a7aB-1zvdA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 GLU A 404
TYR A 482
HIS A 479
PHE A 403
 None
 1.20A 4a97E-1zvdA:
undetectable		 4a97E-1zvdA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 4c3aA-1zvdA:
0.0
4c3aB-1zvdA:
0.0		 4c3aA-1zvdA:
22.91
4c3aB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.49A 4c3aA-1zvdA:
0.0
4c3aB-1zvdA:
0.0		 4c3aA-1zvdA:
22.91
4c3aB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4cftA-1zvdA:
0.0
4cftB-1zvdA:
0.0		 4cftA-1zvdA:
22.91
4cftB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.47A 4cftA-1zvdA:
0.0
4cftB-1zvdA:
0.0		 4cftA-1zvdA:
22.91
4cftB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.48A 4ctyA-1zvdA:
0.0
4ctyB-1zvdA:
0.0		 4ctyA-1zvdA:
22.91
4ctyB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.49A 4ctyA-1zvdA:
0.0
4ctyB-1zvdA:
0.0		 4ctyA-1zvdA:
22.91
4ctyB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.41A 4ctzA-1zvdA:
0.0
4ctzB-1zvdA:
0.0		 4ctzA-1zvdA:
22.91
4ctzB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.49A 4cu0A-1zvdA:
0.0
4cu0B-1zvdA:
0.0		 4cu0A-1zvdA:
22.91
4cu0B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.49A 4cu1A-1zvdA:
0.0
4cu1B-1zvdA:
0.0		 4cu1A-1zvdA:
22.91
4cu1B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4cwvA-1zvdA:
0.0
4cwvB-1zvdA:
0.0		 4cwvA-1zvdA:
22.91
4cwvB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.48A 4cwvA-1zvdA:
0.0
4cwvB-1zvdA:
0.0		 4cwvA-1zvdA:
22.91
4cwvB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.42A 4cwwA-1zvdA:
0.0
4cwwB-1zvdA:
0.0		 4cwwA-1zvdA:
22.91
4cwwB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.41A 4cwwA-1zvdA:
0.0
4cwwB-1zvdA:
0.0		 4cwwA-1zvdA:
22.91
4cwwB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 4cwxA-1zvdA:
0.0
4cwxB-1zvdA:
0.0		 4cwxA-1zvdA:
22.91
4cwxB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 7 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.45A 4cwxA-1zvdA:
0.0
4cwxB-1zvdA:
0.0		 4cwxA-1zvdA:
22.91
4cwxB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 7 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4cwyA-1zvdA:
0.0
4cwyB-1zvdA:
0.0		 4cwyA-1zvdA:
22.91
4cwyB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 7 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.47A 4cwyA-1zvdA:
0.0
4cwyB-1zvdA:
0.0		 4cwyA-1zvdA:
22.91
4cwyB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.41A 4cwzA-1zvdA:
0.0
4cwzB-1zvdA:
0.0		 4cwzA-1zvdA:
22.91
4cwzB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.43A 4cwzA-1zvdA:
0.0
4cwzB-1zvdA:
0.0		 4cwzA-1zvdA:
22.91
4cwzB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4cx0A-1zvdA:
0.0
4cx0B-1zvdA:
0.0		 4cx0A-1zvdA:
22.91
4cx0B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.47A 4cx0A-1zvdA:
0.0
4cx0B-1zvdA:
0.0		 4cx0A-1zvdA:
22.91
4cx0B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_A_H4BA1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4d1oA-1zvdA:
0.0
4d1oB-1zvdA:
0.0		 4d1oA-1zvdA:
22.57
4d1oB-1zvdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.43A 4d1oA-1zvdA:
0.0
4d1oB-1zvdA:
0.0		 4d1oA-1zvdA:
22.57
4d1oB-1zvdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.44A 4d1pA-1zvdA:
0.0
4d1pB-1zvdA:
0.0		 4d1pA-1zvdA:
22.57
4d1pB-1zvdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.50A 4d36A-1zvdA:
0.0
4d36B-1zvdA:
0.0		 4d36A-1zvdA:
22.91
4d36B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.49A 4d37A-1zvdA:
0.0
4d37B-1zvdA:
0.0		 4d37A-1zvdA:
22.91
4d37B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.49A 4d39A-1zvdA:
0.0
4d39B-1zvdA:
0.0		 4d39A-1zvdA:
22.91
4d39B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 8 PHE A 504
ILE A 626
PHE A 508
GLY A 487
 None
 1.01A 4fgjA-1zvdA:
undetectable
4fgjB-1zvdA:
undetectable		 4fgjA-1zvdA:
20.92
4fgjB-1zvdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 8 ILE A 625
LEU A 683
ILE A 500
GLY A 630
 None
 0.85A 4hb6A-1zvdA:
undetectable		 4hb6A-1zvdA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 4imxA-1zvdA:
0.0
4imxB-1zvdA:
0.0		 4imxA-1zvdA:
22.91
4imxB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_B_H4BB502_1
(SUBUNIT A)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.49A 4imxA-1zvdA:
0.0
4imxB-1zvdA:
0.0		 4imxA-1zvdA:
22.91
4imxB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSK_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.49A 4jskA-1zvdA:
0.0
4jskB-1zvdA:
0.0		 4jskA-1zvdA:
22.91
4jskB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.44A 4jslA-1zvdA:
0.0
4jslB-1zvdA:
0.0		 4jslA-1zvdA:
22.91
4jslB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.44A 4jslA-1zvdA:
0.0
4jslB-1zvdA:
0.0		 4jslA-1zvdA:
22.91
4jslB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.44A 4jsmA-1zvdA:
0.0
4jsmB-1zvdA:
0.0		 4jsmA-1zvdA:
22.91
4jsmB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.46A 4jsmA-1zvdA:
0.0
4jsmB-1zvdA:
0.0		 4jsmA-1zvdA:
22.91
4jsmB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 9 PHE A 483
PHE A 504
ILE A 489
MET A 490
 None
 1.36A 4jvlA-1zvdA:
undetectable		 4jvlA-1zvdA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.44A 4k5hA-1zvdA:
0.0
4k5hB-1zvdA:
0.0		 4k5hA-1zvdA:
22.91
4k5hB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.45A 4k5hA-1zvdA:
0.0
4k5hB-1zvdA:
0.0		 4k5hA-1zvdA:
22.91
4k5hB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4k5iA-1zvdA:
0.0
4k5iB-1zvdA:
0.0		 4k5iA-1zvdA:
22.91
4k5iB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.47A 4k5iA-1zvdA:
0.0
4k5iB-1zvdA:
0.0		 4k5iA-1zvdA:
22.91
4k5iB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4k5jA-1zvdA:
0.0
4k5jB-1zvdA:
0.0		 4k5jA-1zvdA:
22.91
4k5jB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 4k5kA-1zvdA:
0.0
4k5kB-1zvdA:
0.0		 4k5kA-1zvdA:
22.91
4k5kB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.45A 4k5kA-1zvdA:
0.0
4k5kB-1zvdA:
0.0		 4k5kA-1zvdA:
22.91
4k5kB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.48A 4kcpA-1zvdA:
0.0
4kcpB-1zvdA:
0.0		 4kcpA-1zvdA:
22.91
4kcpB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.48A 4kcpA-1zvdA:
0.0
4kcpB-1zvdA:
0.0		 4kcpA-1zvdA:
22.91
4kcpB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4kcqA-1zvdA:
0.0
4kcqB-1zvdA:
0.0		 4kcqA-1zvdA:
22.91
4kcqB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.46A 4kcqA-1zvdA:
0.0
4kcqB-1zvdA:
0.0		 4kcqA-1zvdA:
22.91
4kcqB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.50A 4kcsA-1zvdA:
0.0
4kcsB-1zvdA:
0.0		 4kcsA-1zvdA:
22.91
4kcsB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		3 / 3 GLU A 607
ARG A 488
HIS A 484
 None
 0.74A 4kf9A-1zvdA:
undetectable		 4kf9A-1zvdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.48A 4luwA-1zvdA:
0.0
4luwB-1zvdA:
0.0		 4luwA-1zvdA:
22.91
4luwB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.45A 4luwA-1zvdA:
0.0
4luwB-1zvdA:
0.0		 4luwA-1zvdA:
22.91
4luwB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		3 / 3 ASP A 721
HIS A 714
LYS A 712
 None
 1.00A 4qzuD-1zvdA:
undetectable		 4qzuD-1zvdA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4uh7A-1zvdA:
0.0
4uh7B-1zvdA:
0.0		 4uh7A-1zvdA:
22.91
4uh7B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.47A 4uh8A-1zvdA:
0.0
4uh8B-1zvdA:
0.0		 4uh8A-1zvdA:
22.91
4uh8B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.50A 4uh8A-1zvdA:
0.0
4uh8B-1zvdA:
0.0		 4uh8A-1zvdA:
22.91
4uh8B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4uhaA-1zvdA:
0.0
4uhaB-1zvdA:
0.0		 4uhaA-1zvdA:
22.91
4uhaB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.47A 4uhaA-1zvdA:
0.0
4uhaB-1zvdA:
0.0		 4uhaA-1zvdA:
22.91
4uhaB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 4upqA-1zvdA:
0.0
4upqB-1zvdA:
0.0		 4upqA-1zvdA:
22.91
4upqB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.47A 4upqA-1zvdA:
0.0
4upqB-1zvdA:
0.0		 4upqA-1zvdA:
22.91
4upqB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.44A 4uprA-1zvdA:
0.0
4uprB-1zvdA:
0.0		 4uprA-1zvdA:
22.91
4uprB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.45A 4uprA-1zvdA:
0.0
4uprB-1zvdA:
0.0		 4uprA-1zvdA:
22.91
4uprB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.44A 4upsA-1zvdA:
0.0
4upsB-1zvdA:
0.0		 4upsA-1zvdA:
22.91
4upsB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.45A 4upsA-1zvdA:
0.0
4upsB-1zvdA:
0.0		 4upsA-1zvdA:
22.91
4upsB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 4uptA-1zvdA:
0.0
4uptB-1zvdA:
0.0		 4uptA-1zvdA:
22.91
4uptB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.46A 4uptA-1zvdA:
0.0
4uptB-1zvdA:
0.0		 4uptA-1zvdA:
22.91
4uptB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.45A 5adjA-1zvdA:
0.0
5adjB-1zvdA:
0.0		 5adjA-1zvdA:
22.91
5adjB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.50A 5adjA-1zvdA:
0.0
5adjB-1zvdA:
0.0		 5adjA-1zvdA:
22.91
5adjB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.47A 5adkA-1zvdA:
0.0
5adkB-1zvdA:
0.0		 5adkA-1zvdA:
22.91
5adkB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.48A 5adkA-1zvdA:
0.0
5adkB-1zvdA:
0.0		 5adkA-1zvdA:
22.91
5adkB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.49A 5adlA-1zvdA:
0.0
5adlB-1zvdA:
0.0		 5adlA-1zvdA:
22.91
5adlB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 5admA-1zvdA:
0.0
5admB-1zvdA:
0.0		 5admA-1zvdA:
22.91
5admB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.49A 5admA-1zvdA:
0.0
5admB-1zvdA:
0.0		 5admA-1zvdA:
22.91
5admB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 5adnA-1zvdA:
0.0
5adnB-1zvdA:
0.0		 5adnA-1zvdA:
22.91
5adnB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		5 / 12 GLY A 502
ARG A 680
PHE A 457
LEU A 450
MET A 449
 None
 1.40A 5fhzA-1zvdA:
undetectable		 5fhzA-1zvdA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.41A 5fj2A-1zvdA:
0.0
5fj2B-1zvdA:
0.0		 5fj2A-1zvdA:
22.91
5fj2B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.48A 5fj2A-1zvdA:
0.0
5fj2B-1zvdA:
0.0		 5fj2A-1zvdA:
22.91
5fj2B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.46A 5fvyA-1zvdA:
0.0
5fvyB-1zvdA:
0.0		 5fvyA-1zvdA:
22.91
5fvyB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.47A 5fvzA-1zvdA:
0.0
5fvzB-1zvdA:
0.0		 5fvzA-1zvdA:
22.91
5fvzB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		6 / 12 ARG A 680
GLY A 502
ILE A 632
PHE A 686
THR A 676
GLY A 677
 None
None
None
None
NA  A 800 (-4.7A)
None
 1.36A 5koxA-1zvdA:
undetectable		 5koxA-1zvdA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.43A 5uodA-1zvdA:
0.0
5uodB-1zvdA:
0.0		 5uodA-1zvdA:
22.91
5uodB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.44A 5uodA-1zvdA:
0.0
5uodB-1zvdA:
0.0		 5uodA-1zvdA:
22.91
5uodB-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.48A 5vv6A-1zvdA:
0.0
5vv6B-1zvdA:
0.0		 5vv6A-1zvdA:
22.91
5vv6B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.50A 5vv7A-1zvdA:
0.0
5vv7B-1zvdA:
0.0		 5vv7A-1zvdA:
22.91
5vv7B-1zvdA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 7 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.49A 5vvdA-1zvdA:
undetectable
5vvdB-1zvdA:
0.0		 5vvdA-1zvdA:
22.57
5vvdB-1zvdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		5 / 8 LEU A 513
LEU A 512
LEU A 624
GLY A 628
ARG A 680
 None
 1.12A 6ce2A-1zvdA:
undetectable		 6ce2A-1zvdA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.41A 8nseA-1zvdA:
0.0
8nseB-1zvdA:
0.0		 8nseA-1zvdA:
22.11
8nseB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.46A 8nseA-1zvdA:
0.0
8nseB-1zvdA:
0.0		 8nseA-1zvdA:
22.11
8nseB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 VAL A 397
TRP A 441
PHE A 485
GLU A 405
 None
 1.48A 9nseA-1zvdA:
0.0
9nseB-1zvdA:
0.0		 9nseA-1zvdA:
22.11
9nseB-1zvdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens) 		4 / 6 PHE A 485
GLU A 405
VAL A 397
TRP A 441
 None
 1.46A 9nseA-1zvdA:
0.0
9nseB-1zvdA:
0.0		 9nseA-1zvdA:
22.11
9nseB-1zvdA:
22.11