SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 4 THR A 559
LEU A 560
VAL A 510
LEU A 504
 None
 1.05A 1fbmB-1zvuA:
undetectable		 1fbmB-1zvuA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		5 / 12 LEU A 343
ILE A 228
ARG A 225
ILE A 180
LEU A 329
 None
 1.20A 1tw4B-1zvuA:
undetectable		 1tw4B-1zvuA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 6 LEU A 660
GLY A 603
LEU A 689
ILE A 672
 None
 0.90A 1yajF-1zvuA:
undetectable		 1yajF-1zvuA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		3 / 3 ASP A 204
VAL A 210
PRO A 213
 None
 0.74A 2avvA-1zvuA:
undetectable		 2avvA-1zvuA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		3 / 3 ARG A  29
VAL A 340
GLY A 237
 None
 0.57A 2avvE-1zvuA:
undetectable		 2avvE-1zvuA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		5 / 12 LEU A  38
LEU A  99
ASN A 167
ALA A  85
ALA A  81
 None
 1.11A 2bm9C-1zvuA:
undetectable		 2bm9C-1zvuA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		5 / 11 ILE A 739
LEU A 692
ASP A 659
ILE A 672
VAL A 691
 None
 1.14A 2fxdA-1zvuA:
undetectable		 2fxdA-1zvuA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 8 THR A 170
ASN A 330
ALA A  30
GLN A  42
 None
 1.01A 2ij7C-1zvuA:
undetectable		 2ij7C-1zvuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 6 LEU A 420
ILE A 386
VAL A 389
ALA A 382
 None
 0.81A 2j5mA-1zvuA:
undetectable		 2j5mA-1zvuA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 5 LEU A 285
ASP A 283
MET A 312
LEU A 321
 None
 1.28A 2qxsA-1zvuA:
undetectable		 2qxsA-1zvuA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 5 LEU A 285
ASP A 283
MET A 312
LEU A 321
 None
 1.28A 2qxsB-1zvuA:
undetectable		 2qxsB-1zvuA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		5 / 10 ALA A 680
ASN A 627
ALA A 628
ALA A 679
SER A 676
 None
 1.16A 2r2vC-1zvuA:
2.2
2r2vF-1zvuA:
2.1
2r2vG-1zvuA:
2.1		 2r2vC-1zvuA:
4.17
2r2vF-1zvuA:
4.17
2r2vG-1zvuA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		3 / 3 ASP A 591
THR A 501
GLU A 588
 None
 0.83A 2zifB-1zvuA:
undetectable		 2zifB-1zvuA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 5 PRO A 112
THR A  66
VAL A  67
GLY A  68
 None
 0.94A 3elzA-1zvuA:
undetectable		 3elzA-1zvuA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		5 / 12 GLY A 168
TYR A  97
LEU A 131
VAL A 188
ALA A 189
 None
 1.23A 3t7vA-1zvuA:
undetectable		 3t7vA-1zvuA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 5 ARG A 444
LEU A 366
VAL A 369
ASP A 445
 None
 0.90A 3ufnA-1zvuA:
undetectable
3ufnB-1zvuA:
undetectable		 3ufnA-1zvuA:
11.06
3ufnB-1zvuA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 7 ARG A 721
LEU A 643
GLY A 601
SER A 598
 None
 0.96A 4cp3A-1zvuA:
undetectable
4cp3B-1zvuA:
undetectable		 4cp3A-1zvuA:
11.69
4cp3B-1zvuA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 8 GLY A 550
LEU A 586
VAL A 544
TYR A 553
 None
 0.93A 4fgzA-1zvuA:
undetectable		 4fgzA-1zvuA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		3 / 3 LEU A 621
LEU A 576
ASN A 615
 None
 0.72A 4otwA-1zvuA:
undetectable		 4otwA-1zvuA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		4 / 5 GLY A 722
ARG A 723
GLY A 719
GLU A 720
 None
 1.25A 4z2eB-1zvuA:
38.0
4z2eC-1zvuA:
undetectable		 4z2eB-1zvuA:
30.50
4z2eC-1zvuA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		3 / 3 LEU A 165
THR A 178
ASN A 328
 None
 0.66A 6baaE-1zvuA:
undetectable		 6baaE-1zvuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		3 / 3 LEU A 165
THR A 178
ASN A 328
 None
 0.66A 6baaF-1zvuA:
undetectable		 6baaF-1zvuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		3 / 3 LEU A 165
THR A 178
ASN A 328
 None
 0.66A 6baaG-1zvuA:
undetectable		 6baaG-1zvuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1zvu TOPOISOMERASE IV
SUBUNIT A
(Escherichia
coli) 		3 / 3 LEU A 165
THR A 178
ASN A 328
 None
 0.66A 6baaH-1zvuA:
2.3		 6baaH-1zvuA:
18.79