SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 12 ALA A  40
GLU A  64
LEU A  68
LEU A 130
HIS A 137
None
0.62A 1uwhA-1zwsA:
24.2
1uwhA-1zwsA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
6 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
None
0.65A 1uwhB-1zwsA:
24.1
1uwhB-1zwsA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 9 LEU A  19
VAL A  27
LEU A  79
LEU A  91
LEU A  95
None
0.69A 1xkkA-1zwsA:
11.9
1xkkA-1zwsA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 11 SER A 118
ILE A 157
LEU A 101
LEU A 111
LEU A 105
None
1.21A 2a15A-1zwsA:
undetectable
2a15A-1zwsA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
7 / 12 GLY A  20
VAL A  27
VAL A  96
ASP A 139
LYS A 141
ASN A 144
MET A 146
None
1.06A 2fumA-1zwsA:
27.1
2fumA-1zwsA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
8 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASP A 139
LYS A 141
ASN A 144
None
0.97A 2fumA-1zwsA:
27.1
2fumA-1zwsA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
7 / 12 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
LYS A 141
ASN A 144
None
0.97A 2fumB-1zwsA:
27.0
2fumB-1zwsA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
6 / 12 LEU A  19
GLY A  20
VAL A  27
LYS A  42
LEU A  68
LEU A  91
None
0.53A 2ivuA-1zwsA:
25.7
2ivuA-1zwsA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 11 ILE A 123
LEU A 105
LEU A 147
ILE A 157
ILE A 154
None
1.09A 2w9sB-1zwsA:
undetectable
2w9sB-1zwsA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
None
1.00A 3gcsA-1zwsA:
22.1
3gcsA-1zwsA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
6 / 12 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
None
1.24A 3gp0A-1zwsA:
22.6
3gp0A-1zwsA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
6 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
None
0.71A 3gp0A-1zwsA:
22.6
3gp0A-1zwsA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
4 / 7 LYS A  42
VAL A  76
LEU A  91
LEU A  95
None
0.81A 3gp0A-1zwsA:
22.6
3gp0A-1zwsA:
28.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
None
0.47A 3hecA-1zwsA:
22.7
3hecA-1zwsA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A  95
None
0.52A 3hecA-1zwsA:
22.7
3hecA-1zwsA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
6 / 12 VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
ILE A  77
None
0.85A 3hegA-1zwsA:
15.8
3hegA-1zwsA:
30.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 8 ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
None
0.53A 3lfaA-1zwsA:
22.3
3lfaA-1zwsA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
6 / 12 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
ILE A  77
None
0.63A 3ohtA-1zwsA:
6.4
3ohtA-1zwsA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
3 / 3 GLU A  64
LEU A  91
LEU A  95
None
0.68A 3ohtA-1zwsA:
6.4
3ohtA-1zwsA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 12 GLY A  20
VAL A  27
ALA A  40
LEU A  68
ILE A  77
None
0.50A 3ohtB-1zwsA:
6.4
3ohtB-1zwsA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
3 / 3 GLU A  64
LEU A  91
LEU A  95
None
0.67A 3ohtB-1zwsA:
6.4
3ohtB-1zwsA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
7 / 12 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
LEU A 130
HIS A 137
None
0.67A 3rgfA-1zwsA:
22.5
3rgfA-1zwsA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
4 / 8 VAL A  27
LYS A  42
ILE A  77
ILE A 160
None
0.67A 3warA-1zwsA:
27.6
3warA-1zwsA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
8 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
None
0.78A 4asdA-1zwsA:
21.9
4asdA-1zwsA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
4 / 8 GLU A 100
GLU A  18
GLY A  22
SER A  21
None
0.77A 4f93B-1zwsA:
undetectable
4f93B-1zwsA:
11.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
6 / 11 VAL A  27
ALA A  40
LYS A  42
LEU A  93
ILE A 160
ASP A 161
None
0.65A 4iaaA-1zwsA:
27.5
4iaaA-1zwsA:
32.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
7 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
LEU A  93
LEU A  95
ASP A 161
None
0.57A 4mkcA-1zwsA:
23.7
4mkcA-1zwsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
4 / 5 GLY A 163
LEU A  93
ILE A  44
LEU A 130
None
0.82A 4o8fA-1zwsA:
undetectable
4o8fA-1zwsA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 10 ALA A  40
LYS A  42
ILE A  77
LEU A  95
VAL A  96
None
0.43A 4rz7A-1zwsA:
28.7
4rz7A-1zwsA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 12 VAL A  27
ALA A  40
LYS A  42
ASP A 161
PHE A 162
None
0.74A 4xv2A-1zwsA:
24.2
4xv2A-1zwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 12 ALA A  40
LYS A  42
LEU A  68
ASP A 161
PHE A 162
None
0.84A 4xv2B-1zwsA:
24.2
4xv2B-1zwsA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 8 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  95
None
0.72A 4zauA-1zwsA:
24.4
4zauA-1zwsA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
4 / 5 GLU A  38
THR A  78
HIS A  74
LEU A 148
None
1.25A 5axaA-1zwsA:
undetectable
5axaA-1zwsA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
None
0.81A 5cswA-1zwsA:
24.1
5cswA-1zwsA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 12 VAL A  27
ALA A  40
LYS A  42
LEU A  68
PHE A 162
None
0.85A 5cswB-1zwsA:
24.0
5cswB-1zwsA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
6 / 12 ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
None
0.71A 5hi2A-1zwsA:
24.9
5hi2A-1zwsA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
5 / 10 GLY A  20
VAL A  27
ALA A  40
ILE A  77
LEU A  95
None
0.43A 5lw1E-1zwsA:
22.8
5lw1E-1zwsA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
7 / 12 GLU A  17
GLY A  20
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  93
None
0.64A 5mafA-1zwsA:
29.2
5mafA-1zwsA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
6 / 12 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  91
None
0.69A 5vcyA-1zwsA:
25.4
5vcyA-1zwsA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
4 / 8 VAL A  27
LYS A  42
ILE A 160
ASP A 161
None
0.75A 5y9mA-1zwsA:
27.3
5y9mA-1zwsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
4 / 7 VAL A  27
LYS A  42
ILE A 160
ASP A 161
None
0.90A 5yf9B-1zwsA:
27.2
5yf9B-1zwsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
4 / 7 LYS A  42
ILE A  77
ILE A 160
ASP A 161
None
0.69A 5ywmX-1zwsA:
27.3
5ywmX-1zwsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo
sapiens)
3 / 3 LEU A 264
GLY A 204
PHE A 236
None
0.58A 6exiC-1zwsA:
undetectable
6exiC-1zwsA:
14.34