SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 9 ASN A  91
ILE A 125
PRO A 126
ILE A 141
THR A 215
 MG  A 900 ( 2.5A)
ADP  A 901 (-4.4A)
None
ADP  A 901 (-3.7A)
ADP  A 901 ( 4.1A)
 0.80A 1aj6A-1zxnA:
17.5		 1aj6A-1zxnA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		3 / 3 VAL A 293
VAL A 299
TRP A 297
 None
 0.86A 1av2A-1zxnA:
undetectable
1av2B-1zxnA:
undetectable		 1av2A-1zxnA:
3.74
1av2B-1zxnA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 12 ASP A  94
ILE A 125
PRO A 126
ILE A 141
THR A 215
 None
ADP  A 901 (-4.4A)
None
ADP  A 901 (-3.7A)
ADP  A 901 ( 4.1A)
 0.85A 1kijA-1zxnA:
27.0		 1kijA-1zxnA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 12 ASN A  91
ILE A 125
PRO A 126
ILE A 141
THR A 215
 MG  A 900 ( 2.5A)
ADP  A 901 (-4.4A)
None
ADP  A 901 (-3.7A)
ADP  A 901 ( 4.1A)
 0.87A 1kijB-1zxnA:
27.2		 1kijB-1zxnA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 11 ILE A  88
ALA A 167
GLY A 166
ASN A 150
ASN A  91
 None
ADP  A 901 (-3.6A)
ADP  A 901 ( 3.4A)
ADP  A 901 (-3.8A)
MG  A 900 ( 2.5A)
 1.27A 1n6cA-1zxnA:
undetectable		 1n6cA-1zxnA:
22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		6 / 7 HIS A  42
THR A  49
TYR A  50
ASN A 163
TYR A 165
LEU A 169
 None
None
None
GOL  A 599 ( 4.7A)
None
None
 0.58A 1qzrA-1zxnA:
51.6		 1qzrA-1zxnA:
50.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		6 / 7 HIS A  42
THR A  49
TYR A  50
ASN A 163
TYR A 165
LEU A 169
 None
None
None
GOL  A 599 ( 4.7A)
None
None
 0.55A 1qzrB-1zxnA:
50.8		 1qzrB-1zxnA:
50.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 7 ASP A 327
GLY A 323
GLY A 322
ASN A 380
PHE A 308
 None
 0.96A 2c49B-1zxnA:
undetectable		 2c49B-1zxnA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 9 GLY A 160
ILE A  88
CYH A 170
PHE A 173
GLY A 164
 None
None
None
None
ADP  A 901 (-3.1A)
 1.15A 3ko0A-1zxnA:
undetectable
3ko0C-1zxnA:
undetectable		 3ko0A-1zxnA:
13.07
3ko0C-1zxnA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 9 GLY A 164
GLY A 160
ILE A  88
CYH A 170
PHE A 173
 ADP  A 901 (-3.1A)
None
None
None
None
 1.18A 3ko0F-1zxnA:
undetectable
3ko0G-1zxnA:
undetectable		 3ko0F-1zxnA:
13.07
3ko0G-1zxnA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 9 GLY A 164
GLY A 160
ILE A  88
CYH A 170
PHE A 173
 ADP  A 901 (-3.1A)
None
None
None
None
 1.17A 3ko0H-1zxnA:
undetectable
3ko0I-1zxnA:
undetectable		 3ko0H-1zxnA:
13.07
3ko0I-1zxnA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 10 GLY A 164
GLY A 160
ILE A  88
CYH A 170
PHE A 173
 ADP  A 901 (-3.1A)
None
None
None
None
 1.17A 3ko0L-1zxnA:
undetectable
3ko0N-1zxnA:
undetectable		 3ko0L-1zxnA:
13.07
3ko0N-1zxnA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		4 / 8 GLY A 160
CYH A 170
PHE A 173
GLY A 164
 None
None
None
ADP  A 901 (-3.1A)
 1.01A 3ko0O-1zxnA:
undetectable
3ko0Q-1zxnA:
undetectable		 3ko0O-1zxnA:
13.07
3ko0Q-1zxnA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 10 GLY A 160
ILE A  88
CYH A 170
PHE A 173
GLY A 164
 None
None
None
None
ADP  A 901 (-3.1A)
 1.17A 3ko0R-1zxnA:
undetectable
3ko0T-1zxnA:
undetectable		 3ko0R-1zxnA:
13.07
3ko0T-1zxnA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		3 / 3 HIS A 325
SER A 390
ASN A 315
 None
 0.91A 3s8pB-1zxnA:
undetectable		 3s8pB-1zxnA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 12 ARG A 242
SER A 103
MET A 102
ALA A  92
ASN A 120
 None
None
None
ADP  A 901 ( 4.8A)
ADP  A 901 (-3.1A)
 1.42A 3t7sC-1zxnA:
undetectable		 3t7sC-1zxnA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 11 ILE A  88
ALA A 167
GLY A 166
ASN A 150
ASN A  91
 None
ADP  A 901 (-3.6A)
ADP  A 901 ( 3.4A)
ADP  A 901 (-3.8A)
MG  A 900 ( 2.5A)
 1.29A 4e47A-1zxnA:
undetectable		 4e47A-1zxnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 11 ILE A  88
ALA A 167
GLY A 166
ASN A 150
ASN A  91
 None
ADP  A 901 (-3.6A)
ADP  A 901 ( 3.4A)
ADP  A 901 (-3.8A)
MG  A 900 ( 2.5A)
 1.29A 4e47B-1zxnA:
undetectable		 4e47B-1zxnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 11 ILE A  88
ALA A 167
GLY A 166
ASN A 150
ASN A  91
 None
ADP  A 901 (-3.6A)
ADP  A 901 ( 3.4A)
ADP  A 901 (-3.8A)
MG  A 900 ( 2.5A)
 1.28A 4e47C-1zxnA:
undetectable		 4e47C-1zxnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 11 ILE A  88
ALA A 167
GLY A 166
ASN A 150
ASN A  91
 None
ADP  A 901 (-3.6A)
ADP  A 901 ( 3.4A)
ADP  A 901 (-3.8A)
MG  A 900 ( 2.5A)
 1.30A 4jdsA-1zxnA:
undetectable		 4jdsA-1zxnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 11 ILE A  88
ALA A 167
GLY A 166
ASN A 150
ASN A  91
 None
ADP  A 901 (-3.6A)
ADP  A 901 ( 3.4A)
ADP  A 901 (-3.8A)
MG  A 900 ( 2.5A)
 1.27A 4jdsB-1zxnA:
undetectable		 4jdsB-1zxnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 11 ILE A  88
ALA A 167
GLY A 166
ASN A 150
ASN A  91
 None
ADP  A 901 (-3.6A)
ADP  A 901 ( 3.4A)
ADP  A 901 (-3.8A)
MG  A 900 ( 2.5A)
 1.29A 4jdsC-1zxnA:
undetectable		 4jdsC-1zxnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 12 ILE A  88
ALA A 167
GLY A 166
ASN A 150
ASN A  91
 None
ADP  A 901 (-3.6A)
ADP  A 901 ( 3.4A)
ADP  A 901 (-3.8A)
MG  A 900 ( 2.5A)
 1.28A 4jlgA-1zxnA:
undetectable		 4jlgA-1zxnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		4 / 5 ILE A 368
VAL A 314
PHE A 363
CYH A 392
 None
 1.31A 4rzvA-1zxnA:
undetectable		 4rzvA-1zxnA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		5 / 11 ILE A  88
ALA A 167
GLY A 166
ASN A 150
ASN A  91
 None
ADP  A 901 (-3.6A)
ADP  A 901 ( 3.4A)
ADP  A 901 (-3.8A)
MG  A 900 ( 2.5A)
 1.29A 5ayfA-1zxnA:
undetectable		 5ayfA-1zxnA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens) 		3 / 3 HIS A 325
SER A 390
ASN A 315
 None
 0.90A 5cprB-1zxnA:
undetectable		 5cprB-1zxnA:
18.67