SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		4 / 8 MET A 269
ALA A   5
PHE A  63
ILE A   4
 None
 1.10A 1gm7A-1zxoA:
undetectable
1gm7B-1zxoA:
1.4		 1gm7A-1zxoA:
19.51
1gm7B-1zxoA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 136
GLY A 117
THR A 116
ALA A 146
 None
 0.54A 2ej3A-1zxoA:
undetectable		 2ej3A-1zxoA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 136
GLY A 117
THR A 116
ALA A 146
 None
 0.53A 2ej3C-1zxoA:
undetectable		 2ej3C-1zxoA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		5 / 12 ARG A 183
LEU A 152
PHE A 169
ALA A 195
ARG A 186
 None
 1.25A 2v0mC-1zxoA:
0.0		 2v0mC-1zxoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		4 / 4 SER A 241
GLY A 240
GLY A 145
GLY A 117
 None
 0.90A 3bogB-1zxoA:
undetectable
3bogD-1zxoA:
0.0		 3bogB-1zxoA:
undetectable
3bogD-1zxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 218
TYR A 229
SER A 118
GLY A 115
LEU A 114
 None
 0.99A 4e1gA-1zxoA:
undetectable		 4e1gA-1zxoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 218
TYR A 229
SER A 118
GLY A 115
LEU A 114
 None
 1.02A 4e1gB-1zxoA:
undetectable		 4e1gB-1zxoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 118
ALA A 195
SER A 144
THR A 116
 None
 0.99A 4ikjA-1zxoA:
undetectable
4ikjB-1zxoA:
undetectable		 4ikjA-1zxoA:
19.65
4ikjB-1zxoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		4 / 4 ASN A 191
SER A 196
ALA A 146
VAL A 147
 None
 1.27A 4x1kC-1zxoA:
undetectable		 4x1kC-1zxoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 136
ASN A 191
ALA A  66
PHE A  35
ASN A  32
 None
 1.16A 5kc4E-1zxoA:
undetectable		 5kc4E-1zxoA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		4 / 4 ASN A 191
SER A 196
ALA A 146
VAL A 147
 None
 1.29A 5nm5A-1zxoA:
0.7		 5nm5A-1zxoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 147
ALA A 195
PRO A 134
ALA A 146
GLY A 145
 None
 1.10A 5tzoA-1zxoA:
undetectable		 5tzoA-1zxoA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A 118
VAL A 147
ALA A 195
ALA A 146
GLY A 145
 None
 1.35A 5tzoC-1zxoA:
undetectable		 5tzoC-1zxoA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 147
ALA A 195
PRO A 134
ALA A 146
GLY A 145
 None
 1.07A 5tzoC-1zxoA:
undetectable		 5tzoC-1zxoA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 249
LEU A 114
GLY A 145
SER A 198
ALA A 202
 None
 1.33A 6ieyA-1zxoA:
undetectable
6ieyB-1zxoA:
undetectable		 6ieyA-1zxoA:
24.44
6ieyB-1zxoA:
24.44