SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		4 / 8 LEU A 275
VAL A 284
LEU A 122
ALA A 109
 None
 0.90A 1fiqC-1zxxA:
1.5		 1fiqC-1zxxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		4 / 6 ASP A  56
VAL A  57
PHE A  50
PRO A  51
 None
 1.37A 2q6oB-1zxxA:
3.0		 2q6oB-1zxxA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		3 / 3 PHE A  41
SER A 119
LEU A 110
 None
 0.67A 2w1bA-1zxxA:
undetectable		 2w1bA-1zxxA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 10 SER A 105
SER A   9
GLY A 108
ALA A 109
PHE A  76
 None
 1.41A 2xh9B-1zxxA:
undetectable		 2xh9B-1zxxA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 7 VAL A 219
ILE A 150
ALA A 146
VAL A 168
GLY A 181
 None
 1.49A 2xrzB-1zxxA:
undetectable		 2xrzB-1zxxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 12 GLY A 138
ASP A 127
GLY A 101
ILE A 100
ALA A 264
 None
 0.86A 3n3iA-1zxxA:
undetectable		 3n3iA-1zxxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 12 GLY A 254
ILE A 100
GLY A 138
ALA A  18
ALA A  19
 None
 0.99A 3sueA-1zxxA:
undetectable		 3sueA-1zxxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		4 / 5 TYR A 106
VAL A  99
SER A 105
GLY A 124
 None
 1.13A 3v4tA-1zxxA:
undetectable
3v4tD-1zxxA:
undetectable		 3v4tA-1zxxA:
23.93
3v4tD-1zxxA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 12 ILE A 137
ASP A 260
THR A 145
ILE A 126
GLU A 222
 None
 1.34A 4i41A-1zxxA:
undetectable		 4i41A-1zxxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 12 VAL A  20
GLY A 124
SER A 265
GLY A 268
THR A   8
 None
 1.21A 4mm8A-1zxxA:
undetectable		 4mm8A-1zxxA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 9 ALA A  19
ALA A  18
GLY A 101
GLY A 124
ASP A 260
 None
 1.06A 4qwuK-1zxxA:
undetectable
4qwuL-1zxxA:
undetectable		 4qwuK-1zxxA:
20.00
4qwuL-1zxxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 9 ALA A  19
ALA A  18
GLY A 101
GLY A 124
ASP A 260
 None
 1.11A 4qwuY-1zxxA:
undetectable
4qwuZ-1zxxA:
undetectable		 4qwuY-1zxxA:
20.00
4qwuZ-1zxxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 12 THR A   8
GLY A  11
GLY A  10
ALA A 142
THR A 145
 None
 1.15A 4uckB-1zxxA:
undetectable		 4uckB-1zxxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		4 / 8 ILE A   4
ALA A  22
VAL A  26
VAL A  98
 None
 0.83A 5ecnD-1zxxA:
undetectable		 5ecnD-1zxxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1zxx 6-PHOSPHOFRUCTOKINAS
E
(Lactobacillus
delbrueckii) 		5 / 12 GLY A 254
ILE A 100
GLY A 138
ALA A  18
ALA A  19
 None
 1.00A 6c2mD-1zxxA:
undetectable		 6c2mD-1zxxA:
12.81