SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zy1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 ASN A 161
LEU A 162
HIS A 157
 None
None
ZN  A 198 (-3.3A)
 0.75A 2q6fB-1zy1A:
undetectable		 2q6fB-1zy1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 ILE A 150
GLU A 154
ILE A  62
LEU A  89
ARG A  84
 None
ZN  A 198 ( 4.8A)
None
None
None
 1.14A 3fpjB-1zy1A:
undetectable		 3fpjB-1zy1A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 4 GLN A  54
PRO A  53
VAL A  13
GLU A  16
 ZN  A 198 (-3.4A)
None
None
None
 1.46A 3huoA-1zy1A:
undetectable		 3huoA-1zy1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 4 ASP A 159
GLY A 160
LYS A  17
GLU A  16
 None
 1.21A 3hznD-1zy1A:
undetectable		 3hznD-1zy1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 145
GLY A 190
ALA A 105
ARG A 123
ALA A 120
 None
 0.90A 3sudC-1zy1A:
undetectable		 3sudC-1zy1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 GLY A 145
GLY A 190
ALA A 105
ARG A 123
ALA A 120
 None
 0.98A 3sugA-1zy1A:
undetectable		 3sugA-1zy1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 5 TYR A 163
SER A 113
LEU A 162
GLN A  54
 None
None
None
ZN  A 198 (-3.4A)
 1.31A 4yo9A-1zy1A:
0.0
4yo9B-1zy1A:
0.0		 4yo9A-1zy1A:
19.29
4yo9B-1zy1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 ARG A 149
HIS A 153
ARG A 123
 None
ZN  A 198 (-3.3A)
None
 1.17A 5iaoC-1zy1A:
undetectable		 5iaoC-1zy1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 ARG A 149
HIS A 153
ARG A 123
 None
ZN  A 198 (-3.3A)
None
 1.10A 5iaoF-1zy1A:
undetectable		 5iaoF-1zy1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 GLU A 154
HIS A 153
ARG A 149
 ZN  A 198 ( 4.8A)
ZN  A 198 (-3.3A)
None
 0.99A 5uunA-1zy1A:
undetectable		 5uunA-1zy1A:
20.69