SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zy2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		5 / 12 ALA A  90
LEU A  50
LEU A  63
ILE A  62
LEU A  54
 None
PHD  A  51 ( 3.8A)
None
None
PHD  A  51 ( 4.3A)
 1.17A 1xdkB-1zy2A:
undetectable		 1xdkB-1zy2A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		4 / 8 ALA A  36
ALA A  30
ILE A  62
GLU A  61
 None
 0.82A 3dtuC-1zy2A:
undetectable
3dtuD-1zy2A:
undetectable		 3dtuC-1zy2A:
13.43
3dtuD-1zy2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		4 / 8 THR A  86
LEU A  63
LEU A  60
GLY A  59
 None
None
None
PHD  A  51 ( 3.9A)
 0.86A 4c9nA-1zy2A:
undetectable		 4c9nA-1zy2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		4 / 7 LEU A   4
VAL A   5
LYS A  38
TYR A  37
 None
 0.93A 4lb2A-1zy2A:
undetectable		 4lb2A-1zy2A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		5 / 12 GLU A  61
LEU A  50
ASP A  56
GLY A  33
LEU A  40
 None
PHD  A  51 ( 3.8A)
None
None
None
 1.26A 5kbwA-1zy2A:
2.0		 5kbwA-1zy2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		5 / 12 GLU A  61
LEU A  50
ASP A  56
GLY A  33
LEU A  40
 None
PHD  A  51 ( 3.8A)
None
None
None
 1.34A 5kc4E-1zy2A:
1.8		 5kc4E-1zy2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		4 / 8 GLU A  31
PRO A  55
GLY A  33
ASP A  56
 None
 0.92A 5kgpA-1zy2A:
undetectable		 5kgpA-1zy2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		4 / 8 GLU A  31
PRO A  55
GLY A  33
ASP A  56
 None
 0.92A 5kgpB-1zy2A:
undetectable		 5kgpB-1zy2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		5 / 8 ILE A 116
ALA A 115
VAL A  48
PHE A  45
VAL A   3
 None
 1.42A 5l94A-1zy2A:
undetectable		 5l94A-1zy2A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		4 / 8 ILE A 112
ALA A 115
ILE A 116
GLU A  74
 None
 0.64A 5mvmA-1zy2A:
undetectable
5mvmB-1zy2A:
undetectable		 5mvmA-1zy2A:
23.53
5mvmB-1zy2A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 1zy2 TRANSCRIPTIONAL
REGULATOR NTRC1
(Aquifex
aeolicus) 		3 / 3 THR A  73
HIS A  44
ASN A   2
 None
 1.00A 5n4tA-1zy2A:
undetectable		 5n4tA-1zy2A:
20.90