SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		7 / 12 LEU A 605
GLY A 606
VAL A 613
ALA A 626
MET A 788
TYR A 790
ASN A 840
 None
None
None
GOL  A 998 ( 3.7A)
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.6A)
None
 0.92A 2fumC-1zy4A:
22.8		 2fumC-1zy4A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 605
LYS A 628
VAL A 656
ILE A 786
 None
None
GOL  A 998 (-4.9A)
None
 0.82A 2hyyA-1zy4A:
20.3		 2hyyA-1zy4A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 831
LEU A 856
GLY A 855
PHE A 854
 None
 0.95A 2tsrB-1zy4A:
undetectable		 2tsrB-1zy4A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 605
ALA A 626
MET A 788
GLY A 852
 None
GOL  A 998 ( 3.7A)
GOL  A 998 ( 4.2A)
None
 0.55A 2yfxA-1zy4A:
19.4		 2yfxA-1zy4A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 800
ILE A 913
LEU A 932
ARG A 928
THR A 795
 None
 1.29A 2zzaB-1zy4A:
undetectable		 2zzaB-1zy4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 605
VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
None
GOL  A 998 (-4.9A)
None
 0.76A 3cs9A-1zy4A:
19.8		 3cs9A-1zy4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 605
VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
None
GOL  A 998 (-4.9A)
None
 0.77A 3cs9B-1zy4A:
20.4		 3cs9B-1zy4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 605
VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
None
GOL  A 998 (-4.9A)
None
 0.78A 3cs9C-1zy4A:
20.1		 3cs9C-1zy4A:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		8 / 12 LEU A 605
GLY A 606
GLY A 608
VAL A 613
ALA A 626
LYS A 628
MET A 788
TYR A 790
 None
None
None
None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.6A)
 0.71A 3fupB-1zy4A:
21.5		 3fupB-1zy4A:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 818
LEU A 820
GLU A 821
LEU A 976
 None
 0.92A 3h5gA-1zy4A:
undetectable
3h5gC-1zy4A:
undetectable		 3h5gA-1zy4A:
7.26
3h5gC-1zy4A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 976
GLN A 818
LEU A 820
GLU A 821
 None
 1.11A 3h5gA-1zy4A:
undetectable
3h5gB-1zy4A:
undetectable		 3h5gA-1zy4A:
7.26
3h5gB-1zy4A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 655
ILE A 831
HIS A 833
ILE A 851
 None
 0.22A 3hegA-1zy4A:
18.9		 3hegA-1zy4A:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 995
ILE A 843
PHE A 842
 None
None
GOL  A 998 ( 4.2A)
 0.89A 3j7zS-1zy4A:
undetectable
3j7za-1zy4A:
undetectable		 3j7zS-1zy4A:
18.11
3j7za-1zy4A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		7 / 12 LEU A 605
GLY A 606
VAL A 613
ALA A 626
LYS A 628
MET A 788
TYR A 790
 None
None
None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.6A)
 0.40A 3lxkA-1zy4A:
21.3		 3lxkA-1zy4A:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 613
LYS A 628
VAL A 656
ILE A 786
 None
None
GOL  A 998 (-4.9A)
None
 0.80A 3mssD-1zy4A:
19.7		 3mssD-1zy4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 613
ALA A 626
CYH A 791
PHE A 842
PHE A 854
GLY A 855
 None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
None
 1.49A 3og7A-1zy4A:
21.9		 3og7A-1zy4A:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 613
ALA A 626
LEU A 647
CYH A 791
PHE A 842
PHE A 854
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
 1.13A 3og7A-1zy4A:
21.9		 3og7A-1zy4A:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 605
VAL A 613
ALA A 626
VAL A 656
ILE A 786
TYR A 790
 None
None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.9A)
None
GOL  A 998 (-4.6A)
 0.40A 3sxrA-1zy4A:
20.0		 3sxrA-1zy4A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 10 LEU A 605
GLY A 606
GLY A 608
VAL A 613
ALA A 626
TYR A 790
 None
None
None
None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.6A)
 0.47A 4ckjA-1zy4A:
20.6		 4ckjA-1zy4A:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 831
LEU A 856
GLY A 855
PHE A 854
 None
 0.82A 4iqqC-1zy4A:
undetectable		 4iqqC-1zy4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 608
VAL A 613
ALA A 626
LYS A 628
MET A 788
 None
None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
 0.69A 4l9iB-1zy4A:
16.6		 4l9iB-1zy4A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 964
VAL A 895
ILE A 962
LEU A 932
SER A 910
 None
 1.38A 4m83A-1zy4A:
undetectable		 4m83A-1zy4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 605
VAL A 613
LYS A 628
HIS A 833
 None
 0.82A 4qrcA-1zy4A:
21.4		 4qrcA-1zy4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 10 LEU A 605
VAL A 613
LEU A 650
VAL A 656
TYR A 790
ILE A 851
 None
None
None
GOL  A 998 (-4.9A)
GOL  A 998 (-4.6A)
None
 0.82A 4u0iA-1zy4A:
20.2		 4u0iA-1zy4A:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 613
ALA A 626
CYH A 791
PHE A 842
GLY A 852
PHE A 854
 None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
None
 0.81A 4xv2A-1zy4A:
22.3		 4xv2A-1zy4A:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 12 ALA A 626
LEU A 647
CYH A 791
PHE A 842
GLY A 852
PHE A 854
 GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
None
 0.93A 4xv2B-1zy4A:
22.3		 4xv2B-1zy4A:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 613
ALA A 626
LEU A 647
CYH A 791
PHE A 842
GLY A 852
PHE A 854
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
None
 0.98A 5cswA-1zy4A:
22.0		 5cswA-1zy4A:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 613
ALA A 626
LEU A 647
CYH A 791
PHE A 842
GLY A 852
PHE A 854
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
None
 0.96A 5cswB-1zy4A:
22.0		 5cswB-1zy4A:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 613
ALA A 626
ILE A 786
PHE A 842
GLY A 852
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
None
 0.67A 5hieA-1zy4A:
4.6		 5hieA-1zy4A:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 613
ALA A 626
ILE A 786
PHE A 842
GLY A 852
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
None
 0.66A 5hieB-1zy4A:
21.7		 5hieB-1zy4A:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 613
ALA A 626
ILE A 786
PHE A 842
GLY A 852
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
None
 0.68A 5hieD-1zy4A:
21.6		 5hieD-1zy4A:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 606
GLY A 608
GLY A 611
VAL A 613
 None
 0.17A 5izjB-1zy4A:
21.0		 5izjB-1zy4A:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 10 LEU A 605
VAL A 613
ALA A 626
VAL A 656
MET A 788
TYR A 790
 None
None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.9A)
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.6A)
 0.77A 5n3hA-1zy4A:
21.5		 5n3hA-1zy4A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 831
LEU A 856
GLY A 855
PHE A 854
 None
 0.88A 5nooB-1zy4A:
undetectable		 5nooB-1zy4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 831
LEU A 856
GLY A 855
PHE A 854
 None
 0.90A 5nooD-1zy4A:
undetectable		 5nooD-1zy4A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 605
VAL A 613
MET A 788
CYH A 791
 None
None
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.3A)
 0.32A 5te0A-1zy4A:
21.7		 5te0A-1zy4A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 975
ALA A 972
LEU A 981
 None
 0.53A 5uunB-1zy4A:
undetectable		 5uunB-1zy4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 605
ALA A 626
LYS A 628
VAL A 656
PHE A 842
GLY A 852
 None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.9A)
GOL  A 998 ( 4.2A)
None
 1.06A 5vcvA-1zy4A:
23.7		 5vcvA-1zy4A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 605
VAL A 613
ALA A 626
LYS A 628
CYH A 791
PHE A 842
 None
None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
 0.90A 5vcyA-1zy4A:
23.8		 5vcyA-1zy4A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 9 ILE A 831
ILE A 851
ILE A 819
LEU A 820
 None
 0.73A 5vkqB-1zy4A:
undetectable
5vkqC-1zy4A:
undetectable		 5vkqB-1zy4A:
11.23
5vkqC-1zy4A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		6 / 12 GLU A 904
GLY A 830
ASP A 907
VAL A 860
VAL A 895
ILE A 906
 None
 1.48A 5vopA-1zy4A:
undetectable		 5vopA-1zy4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 605
ALA A 626
VAL A 656
MET A 788
CYH A 791
 None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.9A)
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.3A)
 0.72A 5w5vA-1zy4A:
12.8		 5w5vA-1zy4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 663
VAL A 644
LEU A 641
ILE A 640
 None
 0.71A 6cb4A-1zy4A:
undetectable		 6cb4A-1zy4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 793
ASP A 844
SER A 846
ARG A 847
 None
 1.01A 6dwdA-1zy4A:
undetectable
6dwdC-1zy4A:
undetectable		 6dwdA-1zy4A:
21.16
6dwdC-1zy4A:
21.16