SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zy8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 106
ALA A  22
GLY A 335
ILE A 336
 None
 0.77A 1d4sB-1zy8A:
undetectable		 1d4sB-1zy8A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLU A 443
VAL K 167
LEU K 164
ALA K 135
 None
 0.94A 1fiqC-1zy8A:
undetectable		 1fiqC-1zy8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 VAL A  33
ILE A 144
ILE A 139
ASP A   8
 None
 0.79A 1uwhB-1zy8A:
undetectable		 1uwhB-1zy8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A  60
GLU A 192
TYR A 359
SER A 168
 None
FAD  A4750 ( 4.3A)
FAD  A4750 (-4.4A)
FAD  A4750 ( 4.0A)
 1.03A 1vidA-1zy8A:
undetectable		 1vidA-1zy8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A 217
SER A 370
ILE A 222
HIS A 419
 None
 0.97A 1yajF-1zy8A:
undetectable		 1yajF-1zy8A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 GLY A 217
SER A 370
ILE A 222
HIS A 419
 None
 1.00A 1yajJ-1zy8A:
undetectable		 1yajJ-1zy8A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 SER A  60
GLU A 192
TYR A 359
SER A 168
 None
FAD  A4750 ( 4.3A)
FAD  A4750 (-4.4A)
FAD  A4750 ( 4.0A)
 1.04A 2cl5B-1zy8A:
undetectable		 2cl5B-1zy8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1zy8 PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS K 165
GLY K 153
PRO K 154
 None
 0.93A 2hreB-1zy8K:
undetectable		 2hreB-1zy8K:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 235
PHE A 237
GLY A 187
GLY A 214
 None
 0.99A 2qr2A-1zy8A:
undetectable
2qr2B-1zy8A:
undetectable		 2qr2A-1zy8A:
20.13
2qr2B-1zy8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLY A 187
GLY A 214
PHE A 235
PHE A 237
 None
 0.95A 2qr2A-1zy8A:
undetectable
2qr2B-1zy8A:
undetectable		 2qr2A-1zy8A:
20.13
2qr2B-1zy8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 SER A  60
GLU A 192
TYR A 359
SER A 168
 None
FAD  A4750 ( 4.3A)
FAD  A4750 (-4.4A)
FAD  A4750 ( 4.0A)
 1.11A 2zvjA-1zy8A:
undetectable		 2zvjA-1zy8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLU A 443
VAL K 167
LEU K 164
ALA K 135
 None
 0.95A 3ax7A-1zy8A:
undetectable		 3ax7A-1zy8A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 GLU A 443
VAL K 167
LEU K 164
ALA K 134
ALA K 135
 None
 1.23A 3ax7B-1zy8A:
undetectable		 3ax7B-1zy8A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A  15
GLY A  42
ILE A 336
GLY A  18
GLY A  17
 FAD  A4750 (-3.7A)
None
None
None
FAD  A4750 (-3.6A)
 1.09A 3axzA-1zy8A:
undetectable		 3axzA-1zy8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 VAL A 138
ALA A 129
ILE A  12
ILE A 315
THR A 130
 None
 1.20A 3clbD-1zy8A:
undetectable		 3clbD-1zy8A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 GLN A   3
ASP A   6
VAL A  33
VAL A 115
GLN A 137
 None
 1.35A 3fi0F-1zy8A:
undetectable		 3fi0F-1zy8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 GLN A   3
ASP A   6
VAL A  33
VAL A 115
GLN A 137
 None
 1.42A 3fi0J-1zy8A:
undetectable		 3fi0J-1zy8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 VAL A 138
ALA A 129
ILE A  12
ILE A 315
THR A 130
 None
 1.19A 3hbbD-1zy8A:
undetectable		 3hbbD-1zy8A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1zy8 PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP K 145
SER K 147
ARG K 130
 None
 0.88A 3loqA-1zy8K:
undetectable		 3loqA-1zy8K:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLU A 431
HIS A 450
ALA A 394
LEU A 455
PRO A 423
 None
 1.18A 3mdzA-1zy8A:
undetectable		 3mdzA-1zy8A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 106
ALA A  22
GLY A 335
ILE A 336
 None
 0.85A 3spkB-1zy8A:
undetectable		 3spkB-1zy8A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASN A 430
ALA A 433
PRO A 355
ALA A 365
 None
 1.23A 3twpD-1zy8A:
undetectable		 3twpD-1zy8A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 443
VAL K 167
LEU K 164
ALA K 135
 None
 0.92A 3uniA-1zy8A:
undetectable		 3uniA-1zy8A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 ILE A  35
GLY A  13
SER A  14
PHE A 107
LEU A  41
 None
FAD  A4750 (-3.4A)
FAD  A4750 ( 4.1A)
None
None
 1.42A 3v7pA-1zy8A:
undetectable		 3v7pA-1zy8A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 MET A 403
LYS A 405
LEU A 407
VAL A 364
 None
 0.79A 4ik7A-1zy8A:
undetectable		 4ik7A-1zy8A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LYS A 375
LEU A 374
GLU A 371
LEU A 407
 None
 1.43A 4k4yE-1zy8A:
undetectable		 4k4yE-1zy8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 293
GLY A 288
ILE A 121
GLU A 291
 None
 0.84A 4mwzB-1zy8A:
undetectable		 4mwzB-1zy8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ILE A 269
VAL A 182
ILE A 184
VAL A 256
 None
 0.63A 4xdtA-1zy8A:
undetectable		 4xdtA-1zy8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 417
SER A 441
ALA A 432
GLU A 431
ALA A 418
 None
 1.41A 4ymgA-1zy8A:
undetectable		 4ymgA-1zy8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 ALA A 147
VAL A  11
GLY A  17
ALA A 331
GLY A 335
 FAD  A4750 (-4.8A)
None
FAD  A4750 (-3.6A)
FAD  A4750 ( 3.9A)
None
 1.17A 4zjzB-1zy8A:
undetectable		 4zjzB-1zy8A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 103
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A4750 (-2.7A)
None
 0.85A 5a06A-1zy8A:
undetectable		 5a06A-1zy8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 103
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A4750 (-2.7A)
None
 0.84A 5a06B-1zy8A:
undetectable		 5a06B-1zy8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 103
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A4750 (-2.7A)
None
 0.84A 5a06C-1zy8A:
undetectable		 5a06C-1zy8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 103
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A4750 (-2.7A)
None
 0.84A 5a06E-1zy8A:
undetectable		 5a06E-1zy8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 103
LEU A  46
GLY A  43
GLY A  42
 None
None
FAD  A4750 (-2.7A)
None
 0.83A 5a06F-1zy8A:
undetectable		 5a06F-1zy8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A  60
GLU A 192
TYR A 359
SER A 168
 None
FAD  A4750 ( 4.3A)
FAD  A4750 (-4.4A)
FAD  A4750 ( 4.0A)
 1.05A 5fhrA-1zy8A:
undetectable		 5fhrA-1zy8A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLU A 334
GLY A  15
THR A  10
PHE A 308
 None
FAD  A4750 (-3.7A)
None
None
 0.92A 5flcB-1zy8A:
undetectable		 5flcB-1zy8A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLU A 334
GLY A  15
THR A  10
PHE A 308
 None
FAD  A4750 (-3.7A)
None
None
 0.90A 5flcF-1zy8A:
undetectable		 5flcF-1zy8A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ILE A 312
PRO A 313
ILE A 315
 None
 0.38A 5hw8F-1zy8A:
undetectable		 5hw8F-1zy8A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 349
HIS A 329
ALA A 432
ALA A 433
GLY A 417
 None
FAD  A4750 (-4.3A)
None
None
None
 0.93A 5igtA-1zy8A:
undetectable		 5igtA-1zy8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER A  53
GLY A 170
ALA A 171
SER A 167
LEU A 275
 FAD  A4750 ( 3.7A)
None
None
None
None
 1.08A 5jvzB-1zy8A:
undetectable		 5jvzB-1zy8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER A  53
GLY A 170
ALA A 171
SER A 167
LEU A 275
 FAD  A4750 ( 3.7A)
None
None
None
None
 1.11A 5kirB-1zy8A:
undetectable		 5kirB-1zy8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 119
LYS A 285
LEU A 289
GLU A 291
LEU A 292
 FAD  A4750 (-4.3A)
None
None
None
None
 1.24A 5nwwA-1zy8A:
undetectable		 5nwwA-1zy8A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A 201
SER A  60
VAL A 177
TRP A 197
 None
 1.17A 5ysiA-1zy8A:
undetectable		 5ysiA-1zy8A:
17.27