SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zy9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 5 THR A  51
LEU A 132
VAL A 127
LEU A 100
 None
 0.91A 1fbmE-1zy9A:
undetectable		 1fbmE-1zy9A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 8 ASP A 387
THR A  88
GLY A 369
GLN A  63
 GOL  A 557 ( 2.9A)
EDO  A 555 ( 4.2A)
None
None
 0.80A 1jr1B-1zy9A:
5.2		 1jr1B-1zy9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 5 TYR A 446
PHE A 391
TYR A 191
PRO A 390
 None
 1.40A 1mclA-1zy9A:
0.0
1mclB-1zy9A:
0.1
1mclP-1zy9A:
undetectable		 1mclA-1zy9A:
15.93
1mclB-1zy9A:
15.93
1mclP-1zy9A:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 THR A  51
LEU A 132
VAL A 127
 None
 0.64A 1mz9E-1zy9A:
undetectable		 1mz9E-1zy9A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		6 / 12 LEU A 505
SER A 506
GLY A 503
VAL A 452
GLY A 483
GLY A 482
 None
 1.34A 1uakA-1zy9A:
undetectable		 1uakA-1zy9A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 6 LEU A 312
LEU A 329
LEU A 298
ILE A 352
 None
 1.00A 1z95A-1zy9A:
undetectable		 1z95A-1zy9A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 7 ALA A 403
ALA A 407
PRO A 390
TYR A 191
 None
 0.99A 2ql8A-1zy9A:
undetectable
2ql8B-1zy9A:
undetectable		 2ql8A-1zy9A:
12.34
2ql8B-1zy9A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 11 ILE A 326
GLY A 367
PHE A 348
PRO A 260
ILE A 352
 None
 1.34A 2y7kA-1zy9A:
undetectable		 2y7kA-1zy9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 10 ILE A 326
GLY A 367
PHE A 348
PRO A 260
ILE A 352
 None
 1.31A 2y7kB-1zy9A:
undetectable		 2y7kB-1zy9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 ILE A 326
GLY A 367
PHE A 348
PRO A 260
ILE A 352
 None
 1.24A 2y7kC-1zy9A:
undetectable		 2y7kC-1zy9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 GLY A 507
GLY A 482
GLY A 503
 None
 0.35A 3bogC-1zy9A:
undetectable		 3bogC-1zy9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 TYR A 448
GLU A 459
ASP A 462
 None
 0.73A 3bxoA-1zy9A:
undetectable		 3bxoA-1zy9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 TYR A 448
GLU A 459
ASP A 462
 None
 0.75A 3bxoB-1zy9A:
2.3		 3bxoB-1zy9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 9 ALA A 358
GLY A 351
ILE A 352
PRO A 260
THR A 258
 None
 1.20A 3el4B-1zy9A:
undetectable		 3el4B-1zy9A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 7 CYH A  68
PHE A 421
PHE A 416
TYR A 104
 None
 1.45A 3hggA-1zy9A:
undetectable		 3hggA-1zy9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 8 PHE A 125
VAL A  48
LEU A 136
PRO A 123
 None
 1.15A 3jq7C-1zy9A:
2.9		 3jq7C-1zy9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 SER A 492
ASP A 494
ASN A 516
 None
 1.03A 3lsfB-1zy9A:
undetectable
3lsfE-1zy9A:
undetectable		 3lsfB-1zy9A:
20.22
3lsfE-1zy9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 ASP A 494
ASN A 516
SER A 492
 None
 0.99A 3lsfB-1zy9A:
undetectable
3lsfE-1zy9A:
undetectable		 3lsfB-1zy9A:
20.22
3lsfE-1zy9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 5 PHE A 364
ILE A 256
ASN A 455
PHE A 324
 None
 1.18A 3octA-1zy9A:
undetectable		 3octA-1zy9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 5 VAL A 154
GLU A  55
LYS A  52
LYS A   0
 None
 1.45A 3rv5C-1zy9A:
undetectable
3rv5D-1zy9A:
undetectable		 3rv5C-1zy9A:
9.58
3rv5D-1zy9A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 LYS A 510
VAL A 512
HIS A 521
 None
 0.46A 3tj7A-1zy9A:
undetectable		 3tj7A-1zy9A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 SER A 264
ASP A 221
ASP A 196
 None
EDO  A 556 ( 4.7A)
None
 0.92A 3uj7A-1zy9A:
undetectable		 3uj7A-1zy9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 LYS A 111
GLU A 156
TRP A  33
 None
 1.34A 3v4tH-1zy9A:
0.7		 3v4tH-1zy9A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 PRO A 260
LEU A 329
LEU A 366
GLN A 218
ILE A 326
 None
 1.44A 4a79A-1zy9A:
undetectable		 4a79A-1zy9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 PRO A 260
LEU A 329
LEU A 366
GLN A 218
ILE A 326
 None
 1.43A 4a79B-1zy9A:
undetectable		 4a79B-1zy9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 GLY A 351
ALA A 347
ILE A 355
LEU A 298
ILE A 326
 None
 1.02A 4aztA-1zy9A:
undetectable		 4aztA-1zy9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 GLY A 351
ALA A 347
ILE A 355
LEU A 298
ILE A 326
 None
 0.99A 4azvA-1zy9A:
undetectable		 4azvA-1zy9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 8 HIS A 122
PRO A 123
ALA A 333
SER A 118
 None
 0.74A 4k0bB-1zy9A:
undetectable		 4k0bB-1zy9A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 PHE A 348
ASN A 176
VAL A 379
ILE A 365
LEU A 329
 None
 1.32A 4k39A-1zy9A:
3.0		 4k39A-1zy9A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 8 HIS A 122
PRO A 123
ALA A 333
SER A 118
 None
 0.74A 4l7iB-1zy9A:
undetectable		 4l7iB-1zy9A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 VAL A 216
PRO A 184
THR A 183
HIS A 418
GLY A 482
 None
 1.23A 4q15A-1zy9A:
undetectable		 4q15A-1zy9A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 VAL A 216
PRO A 184
THR A 183
HIS A 418
GLY A 482
 None
 1.30A 4ydqB-1zy9A:
undetectable		 4ydqB-1zy9A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 4 LEU A  46
TYR A 104
PRO A 151
ILE A  35
 None
 1.13A 5esgA-1zy9A:
undetectable		 5esgA-1zy9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 4 VAL A 473
GLU A 444
GLY A 470
LEU A 431
 None
 1.34A 5g5gC-1zy9A:
0.2		 5g5gC-1zy9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 PHE A 143
LEU A 306
GLU A 353
ARG A 349
ILE A 342
 None
 1.15A 5ifuA-1zy9A:
undetectable		 5ifuA-1zy9A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 THR A 504
SER A 501
ASP A 419
 None
 0.64A 5kvaA-1zy9A:
undetectable		 5kvaA-1zy9A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 THR A 504
SER A 501
ASP A 419
 None
 0.68A 5kvaB-1zy9A:
undetectable		 5kvaB-1zy9A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 12 ASP A 226
GLU A 224
ALA A 259
PHE A 328
ARG A 289
 None
 1.39A 5nd2B-1zy9A:
undetectable		 5nd2B-1zy9A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		5 / 10 ALA A 331
ILE A 326
ILE A 355
PHE A 261
ALA A 297
 None
 1.21A 5nukA-1zy9A:
undetectable		 5nukA-1zy9A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		4 / 8 PRO A 344
GLU A 137
TRP A  62
TYR A 104
 None
 1.11A 5oh1C-1zy9A:
undetectable		 5oh1C-1zy9A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1zy9 ALPHA-GALACTOSIDASE
(Thermotoga
maritima) 		3 / 3 ARG A 414
PRO A  67
TYR A 104
 None
 0.94A 5tzoB-1zy9A:
2.7		 5tzoB-1zy9A:
15.27