SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		5 / 12 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.04A 1q23B-1zybA:
undetectable		 1q23B-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		5 / 12 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.01A 1q23C-1zybA:
undetectable		 1q23C-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		5 / 11 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.07A 1q23F-1zybA:
undetectable		 1q23F-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		5 / 12 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.07A 1q23H-1zybA:
undetectable
1q23I-1zybA:
undetectable		 1q23H-1zybA:
23.32
1q23I-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		5 / 11 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.08A 1q23I-1zybA:
undetectable		 1q23I-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		5 / 9 PHE A  22
PHE A 125
VAL A 115
LEU A  52
LEU A  13
 None
 1.44A 1wrkA-1zybA:
undetectable
1wrkB-1zybA:
0.0		 1wrkA-1zybA:
17.17
1wrkB-1zybA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 125
LEU A  88
LEU A  52
ILE A 110
LEU A 116
 None
 1.00A 1xdkF-1zybA:
undetectable		 1xdkF-1zybA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A  -2
HIS A  -1
HIS A  -4
 GOL  A 223 (-3.7A)
None
None
 0.74A 3ag4A-1zybA:
undetectable		 3ag4A-1zybA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A  -2
HIS A  -1
HIS A  -4
 GOL  A 223 (-3.7A)
None
None
 0.75A 3ag4N-1zybA:
undetectable		 3ag4N-1zybA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 4 GLU A  78
GLY A  58
THR A 103
GLU A 104
 None
 1.10A 3e9xA-1zybA:
undetectable		 3e9xA-1zybA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A  90
PHE A  89
MET A 130
PHE A 120
 None
 1.11A 3ko0D-1zybA:
undetectable
3ko0E-1zybA:
0.3		 3ko0D-1zybA:
16.67
3ko0E-1zybA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 5 MET A 130
PHE A 125
PHE A 120
PHE A  89
 None
 1.25A 3ko0F-1zybA:
undetectable
3ko0G-1zybA:
0.0		 3ko0F-1zybA:
16.67
3ko0G-1zybA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A  90
PHE A  89
MET A 130
PHE A 120
 None
 0.84A 3ko0O-1zybA:
undetectable
3ko0Q-1zybA:
undetectable		 3ko0O-1zybA:
16.67
3ko0Q-1zybA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A  -3
HIS A   0
MET A   1
 GOL  A 223 ( 4.6A)
None
GOL  A 223 (-4.9A)
 0.76A 3mihA-1zybA:
undetectable		 3mihA-1zybA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		5 / 10 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.07A 3u9fI-1zybA:
undetectable		 3u9fI-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		5 / 12 THR A   7
PHE A  54
LEU A  31
VAL A  29
VAL A 108
 None
 1.09A 3u9fJ-1zybA:
undetectable
3u9fK-1zybA:
undetectable		 3u9fJ-1zybA:
23.32
3u9fK-1zybA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 157
LEU A 161
ILE A 211
GLY A 169
 None
 0.81A 4hb6A-1zybA:
undetectable		 4hb6A-1zybA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 124
VAL A 115
LEU A 119
ILE A 110
 None
 0.88A 4r38D-1zybA:
undetectable		 4r38D-1zybA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 5 GLU A  75
THR A 103
HIS A 106
LEU A  55
 None
 1.12A 5axaA-1zybA:
undetectable		 5axaA-1zybA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 5 GLU A  75
THR A 103
HIS A 106
LEU A  55
 None
 1.13A 5axaC-1zybA:
undetectable		 5axaC-1zybA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 4 ASN A 190
LEU A 152
SER A 192
LEU A 180
 None
 1.04A 5kb5A-1zybA:
undetectable		 5kb5A-1zybA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A  60
GLU A  40
HIS A  36
VAL A 105
 None
None
GOL  A 222 (-4.4A)
None
 1.15A 6j20A-1zybA:
undetectable		 6j20A-1zybA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1zyb TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A   8
GLN A  10
PHE A   5
PHE A  33
 None
None
GOL  A 223 (-4.8A)
None
 1.40A 6nmpP-1zybA:
undetectable
6nmpW-1zybA:
undetectable		 6nmpP-1zybA:
20.00
6nmpW-1zybA:
14.63