SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 8 LEU A 100
ASP A 102
GLY A 112
VAL A  71
 None
 0.80A 1d4sB-1zyeA:
undetectable		 1d4sB-1zyeA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 7 PHE A  37
SER A  55
ALA A  53
ILE A  52
 None
 1.06A 1fxhA-1zyeA:
undetectable
1fxhB-1zyeA:
undetectable		 1fxhA-1zyeA:
20.76
1fxhB-1zyeA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 8 PRO A  40
THR A  44
CYH A  47
ARG A 123
 None
 0.65A 1h4oB-1zyeA:
19.2		 1h4oB-1zyeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 8 PRO A  40
THR A  44
CYH A  47
ARG A 123
 None
 0.66A 1h4oG-1zyeA:
19.0		 1h4oG-1zyeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 4 LEU A 115
PRO A 118
LEU A 120
ARG A 123
 None
 1.23A 1hrkB-1zyeA:
2.2		 1hrkB-1zyeA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 8 ASP A  56
PHE A  54
MET A  95
LEU A  99
 None
 1.04A 1lhvA-1zyeA:
undetectable		 1lhvA-1zyeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 8 PRO A  40
THR A  44
CYH A  47
ARG A 123
 None
 0.72A 1oc3A-1zyeA:
19.0		 1oc3A-1zyeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 8 TYR A  39
GLY A  13
THR A  14
ALA A  15
 None
 0.83A 2a1hA-1zyeA:
undetectable
2a1hB-1zyeA:
undetectable		 2a1hA-1zyeA:
22.88
2a1hB-1zyeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 7 GLY A 124
SER A  72
PHE A  37
ARG A 146
 None
 0.92A 2c8aB-1zyeA:
undetectable		 2c8aB-1zyeA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 7 GLY A 124
SER A  72
PHE A  37
ARG A 146
 None
 1.07A 2c8aD-1zyeA:
undetectable		 2c8aD-1zyeA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 4 LEU A 115
PRO A 118
LEU A 120
ARG A 123
 None
 1.33A 2hrcA-1zyeA:
undetectable		 2hrcA-1zyeA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 4 LEU A 115
PRO A 118
LEU A 120
ARG A 123
 None
 1.17A 2hrcB-1zyeA:
2.3		 2hrcB-1zyeA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_A_DMOA700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 6 ASP A 102
PHE A  38
ASP A 110
TYR A 111
 None
 1.19A 2todA-1zyeA:
undetectable
2todB-1zyeA:
0.0		 2todA-1zyeA:
18.59
2todB-1zyeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 4 LEU A 115
PRO A 118
LEU A 120
ARG A 123
 None
 1.31A 3hcoB-1zyeA:
2.2		 3hcoB-1zyeA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		4 / 6 TYR A 111
ASP A 102
GLN A 106
GLU A  23
 None
 1.10A 4azvA-1zyeA:
undetectable		 4azvA-1zyeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		5 / 12 VAL A  73
ASP A  74
LEU A 115
ALA A 121
SER A 108
 None
 1.31A 5nd4B-1zyeA:
undetectable		 5nd4B-1zyeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE
(Bos
taurus) 		5 / 12 VAL A  69
VAL A  71
ASP A 129
ILE A 134
TYR A 111
 None
 1.41A 6mxtA-1zyeA:
undetectable		 6mxtA-1zyeA:
18.30