SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 1zyo SERINE PROTEASE
(Sesbania
mosaic
virus) 		4 / 4 GLY A 285
VAL A 182
TRP A 283
GLY A 282
 None
None
None
GOL  A 500 (-3.7A)
 1.39A 1ng8A-1zyoA:
undetectable		 1ng8A-1zyoA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 1zyo SERINE PROTEASE
(Sesbania
mosaic
virus) 		4 / 4 GLY A 285
VAL A 182
TRP A 283
GLY A 282
 None
None
None
GOL  A 500 (-3.7A)
 1.39A 1ng8B-1zyoA:
undetectable		 1ng8B-1zyoA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1zyo SERINE PROTEASE
(Sesbania
mosaic
virus) 		5 / 10 GLY A 310
VAL A 299
GLY A 300
THR A 274
VAL A 311
 None
None
GOL  A 500 ( 4.7A)
None
None
 1.16A 1pwyE-1zyoA:
undetectable		 1pwyE-1zyoA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1zyo SERINE PROTEASE
(Sesbania
mosaic
virus) 		5 / 12 SER A 200
LEU A 230
VAL A 153
ILE A 155
HIS A 225
 None
 1.22A 3g9eA-1zyoA:
undetectable		 3g9eA-1zyoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 1zyo SERINE PROTEASE
(Sesbania
mosaic
virus) 		4 / 6 LYS A 194
ALA A 193
GLN A 198
VAL A 199
 None
 1.06A 5i8fA-1zyoA:
undetectable		 5i8fA-1zyoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 1zyo SERINE PROTEASE
(Sesbania
mosaic
virus) 		4 / 6 VAL A 153
LYS A 194
ALA A 193
GLN A 198
 None
 1.04A 5i8fA-1zyoA:
undetectable		 5i8fA-1zyoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1zyo SERINE PROTEASE
(Sesbania
mosaic
virus) 		4 / 7 GLY A 260
GLY A 262
SER A 263
LEU A 288
 None
 0.84A 5izfA-1zyoA:
undetectable		 5izfA-1zyoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1zyo SERINE PROTEASE
(Sesbania
mosaic
virus) 		4 / 5 PRO A 189
VAL A 201
GLY A 196
VAL A 153
 None
 0.99A 6ak3B-1zyoA:
undetectable		 6ak3B-1zyoA:
20.94