SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
5 / 10 GLY A  80
PHE A  78
SER A  81
LEU A  39
LEU A  83
None
1.39A 1a8uA-1zypA:
undetectable
1a8uA-1zypA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
5 / 10 GLY A  80
PHE A  78
SER A  81
LEU A  39
LEU A  83
None
1.42A 1a8uB-1zypA:
undetectable
1a8uB-1zypA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 5 SER A  89
THR A  88
GLU A  86
GLY A  84
None
1.09A 1icrA-1zypA:
undetectable
1icrB-1zypA:
undetectable
1icrA-1zypA:
23.21
1icrB-1zypA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 5 GLU A  86
GLY A  84
SER A  89
THR A  88
None
1.05A 1icrA-1zypA:
undetectable
1icrB-1zypA:
undetectable
1icrA-1zypA:
23.21
1icrB-1zypA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 6 SER A  89
THR A  88
GLU A  86
GLY A  84
None
1.08A 1icuA-1zypA:
undetectable
1icuB-1zypA:
undetectable
1icuA-1zypA:
23.21
1icuB-1zypA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 6 GLU A  86
GLY A  84
SER A  89
THR A  88
None
1.07A 1icuA-1zypA:
undetectable
1icuB-1zypA:
undetectable
1icuA-1zypA:
23.21
1icuB-1zypA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 6 SER A  89
THR A  88
GLU A  86
GLY A  84
None
1.14A 1icuC-1zypA:
undetectable
1icuD-1zypA:
undetectable
1icuC-1zypA:
23.21
1icuD-1zypA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 5 SER A  89
THR A  88
GLU A  86
GLY A  84
None
1.10A 1icvC-1zypA:
undetectable
1icvD-1zypA:
undetectable
1icvC-1zypA:
23.21
1icvD-1zypA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 5 GLU A  86
GLY A  84
SER A  89
THR A  88
None
1.07A 1icvC-1zypA:
undetectable
1icvD-1zypA:
undetectable
1icvC-1zypA:
23.21
1icvD-1zypA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 6 SER A  89
THR A  88
GLU A  86
GLY A  84
None
1.07A 1kqbA-1zypA:
undetectable
1kqbB-1zypA:
undetectable
1kqbA-1zypA:
19.37
1kqbB-1zypA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 5 GLU A  86
GLY A  84
SER A  89
THR A  88
None
1.09A 1kqbA-1zypA:
undetectable
1kqbB-1zypA:
undetectable
1kqbA-1zypA:
19.37
1kqbB-1zypA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 6 SER A  89
THR A  88
GLU A  86
GLY A  84
None
1.05A 1kqbC-1zypA:
undetectable
1kqbD-1zypA:
undetectable
1kqbC-1zypA:
19.37
1kqbD-1zypA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 6 GLU A  86
GLY A  84
SER A  89
THR A  88
None
1.07A 1kqbC-1zypA:
undetectable
1kqbD-1zypA:
undetectable
1kqbC-1zypA:
19.37
1kqbD-1zypA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
3 / 3 PHE A  65
LEU A  90
MET A   6
None
0.76A 1mx1D-1zypA:
undetectable
1mx1D-1zypA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 7 ILE A  67
LEU A  23
THR A  18
LEU A  17
None
0.87A 1v55A-1zypA:
undetectable
1v55J-1zypA:
undetectable
1v55A-1zypA:
16.98
1v55J-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 8 ILE A  67
LEU A  23
THR A  18
LEU A  17
None
0.88A 1v55N-1zypA:
undetectable
1v55W-1zypA:
undetectable
1v55N-1zypA:
16.98
1v55W-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 7 LEU A  83
PHE A  78
LEU A   2
PHE A  65
None
0.94A 1wrlE-1zypA:
undetectable
1wrlF-1zypA:
undetectable
1wrlE-1zypA:
20.20
1wrlF-1zypA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 8 LYS A  49
VAL A  50
THR A  68
LEU A  94
None
1.03A 1z2bB-1zypA:
undetectable
1z2bB-1zypA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
5 / 10 VAL A 168
SER A 126
SER A 128
ASN A 131
GLY A 184
None
1.24A 2x2iB-1zypA:
0.0
2x2iB-1zypA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 8 ILE A  67
LEU A  23
THR A  18
LEU A  17
None
0.88A 3abmN-1zypA:
undetectable
3abmW-1zypA:
undetectable
3abmN-1zypA:
16.98
3abmW-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 7 ILE A  67
LEU A  23
THR A  18
LEU A  17
None
0.93A 3ag3A-1zypA:
undetectable
3ag3J-1zypA:
undetectable
3ag3A-1zypA:
16.98
3ag3J-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 8 ILE A  67
LEU A  23
THR A  18
LEU A  17
None
0.89A 3asoN-1zypA:
undetectable
3asoW-1zypA:
undetectable
3asoN-1zypA:
16.98
3asoW-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 8 HIS A 151
ILE A 154
PHE A  78
TYR A 125
None
1.35A 3ccfB-1zypA:
undetectable
3ccfB-1zypA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 4 GLY A 170
VAL A 168
GLY A 157
THR A 158
None
0.80A 3ib2A-1zypA:
undetectable
3ib2A-1zypA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
3 / 3 GLU A 180
PHE A 175
GLN A 183
None
0.89A 3r55A-1zypA:
undetectable
3r55A-1zypA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
5 / 12 PRO A  63
PRO A  82
LEU A  90
ILE A  43
ALA A  25
None
1.35A 4a83A-1zypA:
undetectable
4a83A-1zypA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 8 GLN A 137
TYR A 125
PHE A  78
ASN A 140
None
0.98A 4wryA-1zypA:
undetectable
4wryA-1zypA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 8 GLN A 137
TYR A 125
PHE A  78
ASN A 140
None
0.94A 4wrzA-1zypA:
undetectable
4wrzA-1zypA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 5 PHE A 119
PHE A 181
PHE A 121
VAL A 195
None
0.95A 5a1rA-1zypA:
undetectable
5a1rA-1zypA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
5 / 11 ILE A 115
ILE A 112
VAL A 195
ILE A 191
ALA A 138
None
1.14A 5lg3A-1zypA:
undetectable
5lg3A-1zypA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
5 / 12 ILE A 115
ILE A 112
VAL A 195
ILE A 191
ALA A 138
None
1.11A 5lg3E-1zypA:
undetectable
5lg3E-1zypA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 7 ILE A  67
LEU A  23
THR A  18
LEU A  17
None
0.93A 5xdqN-1zypA:
undetectable
5xdqW-1zypA:
undetectable
5xdqN-1zypA:
16.98
5xdqW-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 7 ILE A  67
LEU A  23
THR A  18
LEU A  17
None
0.95A 5xdxA-1zypA:
undetectable
5xdxJ-1zypA:
undetectable
5xdxA-1zypA:
16.98
5xdxJ-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica)
4 / 5 ILE A  67
LEU A  23
THR A  18
LEU A  17
None
0.89A 6nmpN-1zypA:
undetectable
6nmpW-1zypA:
undetectable
6nmpN-1zypA:
16.98
6nmpW-1zypA:
14.85