SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zz3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 11 THR A  96
ILE A 154
LEU A 108
GLY A 107
ALA A  66
 None
 1.04A 1b02A-1zz3A:
undetectable		 1b02A-1zz3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		9 / 11 HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
LEU A 275
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 4.6A)
3YP  A1452 (-4.6A)
 0.55A 1c3sA-1zz3A:
42.3		 1c3sA-1zz3A:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 11 HIS A 143
HIS A 182
ASP A 268
LEU A 275
TYR A 312
 3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 4.6A)
3YP  A1452 (-4.6A)
 1.11A 1c3sA-1zz3A:
42.3		 1c3sA-1zz3A:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		6 / 12 ASP A  98
HIS A 142
HIS A 143
GLY A 151
ASP A 180
PHE A 208
 None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
ZN  A1451 (-1.9A)
3YP  A1452 (-3.6A)
 1.44A 1t69A-1zz3A:
42.0		 1t69A-1zz3A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		9 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 (-4.6A)
 0.54A 1t69A-1zz3A:
42.0		 1t69A-1zz3A:
26.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 11 HIS A 142
HIS A 182
ASP A 268
GLY A 311
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.24A 1zz1A-1zz3A:
71.3		 1zz1A-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 11 HIS A 143
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 1.05A 1zz1A-1zz3A:
71.3		 1zz1A-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		6 / 11 LEU A  21
HIS A 182
PHE A 208
ASP A 268
GLY A 311
TYR A 312
 None
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.16A 1zz1A-1zz3A:
71.3		 1zz1A-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		11 / 11 LEU A  21
ILE A 100
HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
TYR A 312
 None
None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.52A 1zz1A-1zz3A:
71.3		 1zz1A-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
ASP A 180
HIS A 182
ASP A 268
GLY A 266
 3YP  A1452 (-3.3A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
 1.22A 1zz1B-1zz3A:
70.8
1zz1C-1zz3A:
71.1		 1zz1B-1zz3A:
100.00
1zz1C-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		11 / 12 LEU A  21
ILE A 100
HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
TYR A 312
 None
None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.43A 1zz1B-1zz3A:
70.8
1zz1C-1zz3A:
71.1		 1zz1B-1zz3A:
100.00
1zz1C-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		7 / 12 LEU A  21
ILE A 100
HIS A 182
PHE A 208
ASP A 268
GLY A 311
TYR A 312
 None
None
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.18A 1zz1B-1zz3A:
70.8
1zz1C-1zz3A:
71.1		 1zz1B-1zz3A:
100.00
1zz1C-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 ASP A  98
HIS A 182
GLY A 151
ASP A 268
GLY A 310
 None
ZN  A1451 (-3.3A)
3YP  A1452 (-3.4A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
 1.06A 1zz1C-1zz3A:
71.1		 1zz1C-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 143
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 1.04A 1zz1C-1zz3A:
71.1		 1zz1C-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		12 / 12 LEU A  21
ASP A  98
ILE A 100
HIS A 142
HIS A 143
GLY A 151
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
TYR A 312
 None
None
None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.55A 1zz1C-1zz3A:
71.1		 1zz1C-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		7 / 12 LEU A  21
ILE A 100
HIS A 182
PHE A 208
ASP A 268
GLY A 311
TYR A 312
 None
None
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.19A 1zz1C-1zz3A:
71.1		 1zz1C-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		9 / 9 ILE A 100
HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
TYR A 312
 None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 (-4.6A)
 0.48A 1zz1D-1zz3A:
71.0		 1zz1D-1zz3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 9 ILE A 100
PHE A 152
HIS A 182
PHE A 208
ASP A 180
 None
3YP  A1452 (-3.8A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 (-1.9A)
 1.47A 1zz1D-1zz3A:
71.0		 1zz1D-1zz3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		4 / 7 ALA A 126
GLY A 302
ILE A 304
PRO A 258
 None
 0.88A 2fxdB-1zz3A:
undetectable		 2fxdB-1zz3A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		4 / 7 THR A 158
ALA A 296
PHE A 306
LEU A 253
 None
 1.09A 2hzqA-1zz3A:
undetectable		 2hzqA-1zz3A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		4 / 6 VAL A  14
HIS A  36
TYR A 312
ASN A 138
 None
None
3YP  A1452 (-4.6A)
None
 1.27A 2zs9A-1zz3A:
undetectable		 2zs9A-1zz3A:
24.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 5 HIS A 142
HIS A 143
ASP A 180
HIS A 182
ASP A 268
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
 0.25A 3c0zA-1zz3A:
48.3		 3c0zA-1zz3A:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		8 / 8 HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
 0.37A 3c0zB-1zz3A:
48.3		 3c0zB-1zz3A:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 6 HIS A 142
HIS A 143
ASP A 180
HIS A 182
ASP A 268
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
 0.20A 3c0zC-1zz3A:
48.2		 3c0zC-1zz3A:
33.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		4 / 5 ALA A 135
ALA A 162
TYR A 164
MET A 171
 None
 1.25A 3d91A-1zz3A:
undetectable		 3d91A-1zz3A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		4 / 8 ALA A 126
GLY A 302
ILE A 304
PRO A 258
 None
 0.83A 3el9A-1zz3A:
undetectable		 3el9A-1zz3A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 8 LEU A 177
VAL A 248
ILE A 228
VAL A 230
LEU A 202
 None
 1.01A 3kp6A-1zz3A:
undetectable
3kp6B-1zz3A:
undetectable		 3kp6A-1zz3A:
18.44
3kp6B-1zz3A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 9 ALA A 126
GLY A 302
ILE A 304
PRO A 258
VAL A 174
 None
 1.01A 3nu4A-1zz3A:
undetectable		 3nu4A-1zz3A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 9 ALA A 126
GLY A 302
ILE A 304
PRO A 258
VAL A 174
 None
 1.01A 3nuoA-1zz3A:
undetectable		 3nuoA-1zz3A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		3 / 3 GLN A 308
PHE A  46
TYR A 134
 None
 0.88A 3ucjB-1zz3A:
1.9		 3ucjB-1zz3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		3 / 3 GLN A 308
PHE A  46
TYR A 134
 None
 0.94A 3ucjA-1zz3A:
1.9		 3ucjA-1zz3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 7 ILE A  56
GLY A  54
SER A  53
PHE A  46
LEU A 322
 None
 1.10A 3v7pA-1zz3A:
undetectable		 3v7pA-1zz3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 10 HIS A 142
ASP A 180
HIS A 182
ASP A 268
GLY A 266
 3YP  A1452 (-3.3A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
 1.42A 4bz6A-1zz3A:
40.3		 4bz6A-1zz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		8 / 10 HIS A 142
HIS A 143
ASP A 180
HIS A 182
ASP A 268
PRO A 274
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.61A 4bz6A-1zz3A:
40.3		 4bz6A-1zz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 10 HIS A 142
HIS A 182
ASP A 268
GLY A 311
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.27A 4bz6A-1zz3A:
40.3		 4bz6A-1zz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		9 / 12 HIS A 142
HIS A 143
ASP A 180
HIS A 182
PHE A 208
ASP A 268
PRO A 274
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.67A 4bz6A-1zz3A:
40.3
4bz6B-1zz3A:
40.8		 4bz6A-1zz3A:
22.17
4bz6B-1zz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
HIS A 182
ASP A 268
GLY A 311
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.26A 4bz6A-1zz3A:
40.3
4bz6B-1zz3A:
40.8		 4bz6A-1zz3A:
22.17
4bz6B-1zz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A 142
HIS A 143
GLY A 151
ASP A 180
HIS A 182
PHE A 208
ASP A 268
PRO A 274
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.70A 4bz6C-1zz3A:
40.8		 4bz6C-1zz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
HIS A 182
ASP A 268
GLY A 311
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.26A 4bz6C-1zz3A:
40.8		 4bz6C-1zz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		8 / 10 HIS A 142
HIS A 143
ASP A 180
HIS A 182
ASP A 268
PRO A 274
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.62A 4bz6D-1zz3A:
40.8		 4bz6D-1zz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 10 HIS A 142
HIS A 182
ASP A 268
GLY A 311
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.27A 4bz6D-1zz3A:
40.8		 4bz6D-1zz3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 ASP A  69
ILE A  72
ALA A  75
VAL A 160
ARG A 112
 None
 1.02A 4dx5B-1zz3A:
undetectable		 4dx5B-1zz3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A  36
HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 180
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.69A 4lxzA-1zz3A:
44.6		 4lxzA-1zz3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		6 / 12 HIS A  36
HIS A 143
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 None
3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 1.12A 4lxzA-1zz3A:
44.6		 4lxzA-1zz3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		9 / 11 HIS A  36
HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.66A 4lxzB-1zz3A:
44.6		 4lxzB-1zz3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		6 / 11 HIS A  36
HIS A 143
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 None
3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 1.10A 4lxzB-1zz3A:
44.6		 4lxzB-1zz3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 11 HIS A  36
HIS A 182
ASP A 268
GLY A 311
TYR A 312
 None
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.24A 4lxzB-1zz3A:
44.6		 4lxzB-1zz3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 11 HIS A 142
HIS A 182
ASP A 268
GLY A 311
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.24A 4lxzB-1zz3A:
44.6		 4lxzB-1zz3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		6 / 12 ASP A  98
HIS A 142
HIS A 143
GLY A 151
ASP A 180
PHE A 208
 None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
ZN  A1451 (-1.9A)
3YP  A1452 (-3.6A)
 1.43A 4lxzC-1zz3A:
44.4		 4lxzC-1zz3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.51A 4lxzC-1zz3A:
44.4		 4lxzC-1zz3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 MET A 245
VAL A 249
LEU A 250
VAL A 263
ALA A 175
 None
 1.08A 4o1zB-1zz3A:
undetectable		 4o1zB-1zz3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.59A 4qa0A-1zz3A:
42.2		 4qa0A-1zz3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
HIS A 143
HIS A 182
ASP A 268
GLY A 266
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
 1.32A 4qa0A-1zz3A:
42.2		 4qa0A-1zz3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 143
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 1.04A 4qa0A-1zz3A:
42.2		 4qa0A-1zz3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 182
PHE A 208
ASP A 268
GLY A 311
TYR A 312
 ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.29A 4qa0A-1zz3A:
42.2		 4qa0A-1zz3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		9 / 11 HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.61A 4qa0B-1zz3A:
42.0		 4qa0B-1zz3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 11 HIS A 142
PHE A 152
HIS A 182
GLY A 311
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.8A)
ZN  A1451 (-3.3A)
None
3YP  A1452 (-4.6A)
 1.05A 4qa0B-1zz3A:
42.0		 4qa0B-1zz3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 11 HIS A 143
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 1.05A 4qa0B-1zz3A:
42.0		 4qa0B-1zz3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		6 / 11 PHE A 152
HIS A 182
PHE A 208
ASP A 268
GLY A 311
TYR A 312
 3YP  A1452 (-3.8A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.30A 4qa0B-1zz3A:
42.0		 4qa0B-1zz3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.54A 4qa2A-1zz3A:
42.4		 4qa2A-1zz3A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 143
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 1.05A 4qa2A-1zz3A:
42.4		 4qa2A-1zz3A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		6 / 12 PHE A 152
HIS A 182
PHE A 208
ASP A 268
GLY A 311
TYR A 312
 3YP  A1452 (-3.8A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.25A 4qa2A-1zz3A:
42.4		 4qa2A-1zz3A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.52A 4qa2B-1zz3A:
42.4		 4qa2B-1zz3A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
HIS A 143
HIS A 182
ASP A 268
GLY A 266
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
 1.28A 4qa2B-1zz3A:
42.4		 4qa2B-1zz3A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 143
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 1.06A 4qa2B-1zz3A:
42.4		 4qa2B-1zz3A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		6 / 12 PHE A 152
HIS A 182
PHE A 208
ASP A 268
GLY A 311
TYR A 312
 3YP  A1452 (-3.8A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.25A 4qa2B-1zz3A:
42.4		 4qa2B-1zz3A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 ASP A  69
ILE A  72
ALA A  75
VAL A 160
ARG A 112
 None
 1.06A 4u8vB-1zz3A:
undetectable		 4u8vB-1zz3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 ASP A  69
ILE A  72
ALA A  75
VAL A 160
ARG A 112
 None
 1.11A 4u8yB-1zz3A:
0.2		 4u8yB-1zz3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		4 / 7 ILE A 304
LEU A 177
ALA A 289
ILE A 293
 None
 0.79A 4y03A-1zz3A:
undetectable		 4y03A-1zz3A:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
LEU A 275
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 4.6A)
3YP  A1452 (-4.6A)
 0.45A 5eeiA-1zz3A:
50.4		 5eeiA-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A 142
HIS A 143
GLY A 151
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
LEU A 275
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 4.6A)
3YP  A1452 (-4.6A)
 0.45A 5eeiB-1zz3A:
50.5		 5eeiB-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
HIS A 182
ASP A 268
LEU A 275
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 4.6A)
3YP  A1452 (-4.6A)
 0.98A 5eeiB-1zz3A:
50.5		 5eeiB-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A  36
HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
GLY A 310
TYR A 312
 None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 0.50A 5eenA-1zz3A:
50.3		 5eenA-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A  36
HIS A 143
HIS A 182
ASP A 268
TYR A 312
 None
3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 (-4.6A)
 1.16A 5eenA-1zz3A:
50.3		 5eenA-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		6 / 12 HIS A  36
HIS A 182
PHE A 208
ASP A 268
GLY A 311
TYR A 312
 None
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
None
3YP  A1452 (-4.6A)
 1.33A 5eenA-1zz3A:
50.3		 5eenA-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
ASP A 180
HIS A 182
ASP A 268
GLY A 266
 3YP  A1452 (-3.3A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
None
 1.33A 5eenA-1zz3A:
50.3		 5eenA-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
HIS A 182
ASP A 268
GLY A 310
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 3.7A)
3YP  A1452 (-4.6A)
 1.06A 5eenA-1zz3A:
50.3		 5eenA-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		10 / 12 HIS A  36
HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
LEU A 275
TYR A 312
 None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 4.6A)
3YP  A1452 (-4.6A)
 0.65A 5eenB-1zz3A:
50.3		 5eenB-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A  36
HIS A 143
HIS A 182
ASP A 268
TYR A 312
 None
3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 (-4.6A)
 1.16A 5eenB-1zz3A:
50.3		 5eenB-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
HIS A 182
ASP A 268
LEU A 275
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 4.6A)
3YP  A1452 (-4.6A)
 0.93A 5eenB-1zz3A:
50.3		 5eenB-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		9 / 12 HIS A  36
HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
TYR A 312
 None
3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 (-4.6A)
 0.50A 5ef8A-1zz3A:
50.3		 5ef8A-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A  36
HIS A 143
HIS A 182
ASP A 268
TYR A 312
 None
3YP  A1452 (-3.4A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 (-4.6A)
 1.11A 5ef8A-1zz3A:
50.3		 5ef8A-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		9 / 12 HIS A 142
HIS A 143
PHE A 152
ASP A 180
HIS A 182
PHE A 208
ASP A 268
LEU A 275
TYR A 312
 3YP  A1452 (-3.3A)
3YP  A1452 (-3.4A)
3YP  A1452 (-3.8A)
ZN  A1451 (-1.9A)
ZN  A1451 (-3.3A)
3YP  A1452 (-3.6A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 4.6A)
3YP  A1452 (-4.6A)
 0.54A 5ef8B-1zz3A:
50.5		 5ef8B-1zz3A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 12 HIS A 142
HIS A 182
ASP A 268
LEU A 275
TYR A 312
 3YP  A1452 (-3.3A)
ZN  A1451 (-3.3A)
ZN  A1451 ( 2.5A)
3YP  A1452 ( 4.6A)
3YP  A1452 (-4.6A)
 0.92A 5ef8B-1zz3A:
50.5		 5ef8B-1zz3A:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		5 / 9 ALA A 126
GLY A 302
ILE A 304
PRO A 258
VAL A 174
 None
 1.14A 5kr0A-1zz3A:
undetectable		 5kr0A-1zz3A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		4 / 7 ARG A 124
VAL A 305
GLY A   4
TYR A   5
 None
 0.82A 5x80C-1zz3A:
undetectable
5x80D-1zz3A:
undetectable		 5x80C-1zz3A:
19.62
5x80D-1zz3A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE
(Alcaligenaceae
bacterium
FB188) 		4 / 5 GLY A 186
THR A 187
HIS A 183
SER A 201
 None
None
None
K  A1450 (-2.6A)
 1.15A 6jmjA-1zz3A:
undetectable		 6jmjA-1zz3A:
17.34