SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 7 LEU A   2
ALA A 216
LEU A 228
SER A 227
 None
 1.00A 1dvxA-1zzgA:
undetectable		 1dvxA-1zzgA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 8 TYR A 250
LEU A 343
LEU A 366
GLU A 252
 None
 1.10A 1i7zA-1zzgA:
undetectable		 1i7zA-1zzgA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 ARG A  34
VAL A 184
TRP A  43
 None
 1.18A 1qw6A-1zzgA:
undetectable		 1qw6A-1zzgA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 ARG A  34
VAL A 184
TRP A  43
 None
 1.11A 1qwcA-1zzgA:
undetectable		 1qwcA-1zzgA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 ARG A  34
VAL A 184
TRP A  43
 None
 1.15A 1vagA-1zzgA:
undetectable		 1vagA-1zzgA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 PHE A 387
GLY A 389
LEU A 264
LEU A 236
LEU A  41
 None
 1.41A 1zgyA-1zzgA:
0.0		 1zgyA-1zzgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 ARG A  34
VAL A 184
TRP A  43
 None
 1.18A 1zviA-1zzgA:
undetectable		 1zviA-1zzgA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 8 PHE A 247
LEU A 257
LEU A 366
LEU A   2
 None
 0.96A 2bfpC-1zzgA:
4.0		 2bfpC-1zzgA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 LEU A 381
LEU A   4
PHE A 247
 None
 0.47A 2pgrA-1zzgA:
undetectable		 2pgrA-1zzgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 5 GLU A 321
PRO A 323
ILE A 322
GLY A 336
 None
 1.13A 2qeuA-1zzgA:
undetectable
2qeuC-1zzgA:
undetectable		 2qeuA-1zzgA:
16.95
2qeuC-1zzgA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 6 PHE A  69
PHE A  95
GLY A 203
ASN A  89
 None
 0.94A 2qr2A-1zzgA:
3.7
2qr2B-1zzgA:
3.5		 2qr2A-1zzgA:
20.68
2qr2B-1zzgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 TYR A 362
LEU A 364
LEU A 257
HIS A 245
LEU A 388
 None
 1.29A 3adxA-1zzgA:
undetectable		 3adxA-1zzgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 7 PHE A 188
GLU A 183
SER A  39
ARG A 187
 None
 1.45A 3dqtA-1zzgA:
undetectable
3dqtB-1zzgA:
undetectable		 3dqtA-1zzgA:
21.21
3dqtB-1zzgA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 7 ARG A   7
ALA A 363
VAL A 361
LEU A 310
 None
 0.76A 3o14A-1zzgA:
undetectable		 3o14A-1zzgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 10 PHE A 188
ALA A 386
PHE A 387
GLY A 389
PHE A 261
 None
 1.44A 3qpsA-1zzgA:
undetectable		 3qpsA-1zzgA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 8 TYR A 362
HIS A 245
LEU A 388
TRP A 392
 None
 1.36A 3uzzB-1zzgA:
undetectable		 3uzzB-1zzgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 10 ALA A  83
LEU A  84
PHE A  88
ALA A 208
ALA A 213
 None
 1.10A 4j14A-1zzgA:
undetectable		 4j14A-1zzgA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 287
ALA A 286
LEU A 257
LEU A 377
LEU A 310
 None
 1.17A 4j24D-1zzgA:
undetectable		 4j24D-1zzgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 GLY A 302
PRO A 303
GLN A 359
 None
 0.57A 4oltB-1zzgA:
0.0		 4oltB-1zzgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 GLY A 302
PRO A 303
GLN A 359
 None
 0.54A 4qwpB-1zzgA:
0.0		 4qwpB-1zzgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 8 TRP A 260
ALA A  83
LEU A  84
GLY A 195
 None
 0.84A 4xk8a-1zzgA:
0.8		 4xk8a-1zzgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 TYR A 362
LEU A 364
PHE A 261
HIS A 245
LEU A 388
 None
 1.40A 4xldA-1zzgA:
0.0		 4xldA-1zzgA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 5 LEU A 236
ALA A 309
LEU A 235
VAL A 311
 None
 1.20A 5cr1A-1zzgA:
undetectable		 5cr1A-1zzgA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 ARG A  94
LYS A 117
GLU A  67
 None
 0.75A 5d0yA-1zzgA:
undetectable		 5d0yA-1zzgA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 ARG A  34
VAL A 184
TRP A  43
 None
 1.06A 5fvoA-1zzgA:
undetectable		 5fvoA-1zzgA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 GLY A 185
GLY A 186
GLN A 399
 None
 0.26A 5imsA-1zzgA:
3.3		 5imsA-1zzgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 GLY A 185
GLN A 399
LYS A 125
 None
 0.90A 5imsB-1zzgA:
4.7		 5imsB-1zzgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 7 PHE A 188
GLU A 183
SER A  39
ARG A 187
 None
 1.45A 5vvnA-1zzgA:
undetectable
5vvnB-1zzgA:
undetectable		 5vvnA-1zzgA:
21.11
5vvnB-1zzgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 5 LEU A  23
LYS A 231
LEU A 224
GLU A 225
 None
 1.14A 5weaA-1zzgA:
3.9		 5weaA-1zzgA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 LEU A   2
GLY A 212
PHE A  88
 None
 0.59A 6exiC-1zzgA:
2.7		 6exiC-1zzgA:
12.05