SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1zzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		5 / 12 ILE A 325
GLY A 332
GLY A 411
LEU A 405
LEU A 322
 None
None
SO4  A 501 (-4.2A)
None
None
 1.05A 1rjdA-1zzwA:
undetectable		 1rjdA-1zzwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		5 / 12 ILE A 325
GLY A 332
GLY A 411
LEU A 405
LEU A 322
 None
None
SO4  A 501 (-4.2A)
None
None
 1.04A 1rjdB-1zzwA:
undetectable		 1rjdB-1zzwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		5 / 12 ILE A 325
GLY A 332
GLY A 411
LEU A 405
LEU A 322
 None
None
SO4  A 501 (-4.2A)
None
None
 1.04A 1rjdC-1zzwA:
undetectable		 1rjdC-1zzwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		5 / 9 ARG A 442
ILE A 325
LYS A 441
ALA A 416
LEU A 423
 None
 1.44A 3o01A-1zzwA:
undetectable
3o01B-1zzwA:
undetectable		 3o01A-1zzwA:
18.53
3o01B-1zzwA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 7 LEU A 358
ALA A 337
ILE A 325
THR A 355
 None
 0.99A 4eyrA-1zzwA:
undetectable		 4eyrA-1zzwA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		3 / 3 ARG A 384
GLN A 454
GLU A 457
 None
 0.88A 4tvtA-1zzwA:
undetectable		 4tvtA-1zzwA:
20.10