SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a0j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		5 / 12 LEU A 114
LEU A 117
LEU A 120
ALA A 121
LEU A  59
 None
 0.90A 1s9pC-2a0jA:
undetectable		 1s9pC-2a0jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		3 / 3 GLU A  52
GLU A  46
LEU A 104
 None
 0.75A 1v8bB-2a0jA:
undetectable		 1v8bB-2a0jA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		4 / 5 PHE A  89
THR A  57
LEU A  59
ALA A  91
 None
 1.30A 2e1qD-2a0jA:
undetectable		 2e1qD-2a0jA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		3 / 3 GLU A  36
HIS A  12
THR A  77
 None
 0.79A 3hkuA-2a0jA:
undetectable		 3hkuA-2a0jA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		4 / 8 ALA A  64
GLY A  58
THR A  57
GLU A  52
 None
 0.92A 3rglA-2a0jA:
undetectable		 3rglA-2a0jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		4 / 8 ILE A 100
SER A  21
GLU A  27
VAL A  19
 None
 0.81A 3ua5A-2a0jA:
undetectable		 3ua5A-2a0jA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		4 / 8 ILE A 102
SER A  21
GLU A  27
VAL A  19
 None
 0.84A 3ua5A-2a0jA:
undetectable		 3ua5A-2a0jA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		4 / 7 ILE A 100
SER A  21
GLU A  27
VAL A  19
 None
 0.83A 3ua5B-2a0jA:
undetectable		 3ua5B-2a0jA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		4 / 7 ILE A 102
SER A  21
GLU A  27
VAL A  19
 None
 0.82A 3ua5B-2a0jA:
undetectable		 3ua5B-2a0jA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		5 / 11 ALA A  64
THR A  83
MET A  17
VAL A  87
THR A  57
 None
 1.45A 4kyaA-2a0jA:
undetectable		 4kyaA-2a0jA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		5 / 11 ALA A  64
THR A  83
MET A  17
VAL A  87
THR A  57
 None
 1.45A 4kyaE-2a0jA:
undetectable		 4kyaE-2a0jA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		3 / 3 HIS A  12
VAL A 116
LEU A 103
 None
 0.76A 4m2vA-2a0jA:
undetectable		 4m2vA-2a0jA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		5 / 12 GLY A  68
GLY A  30
LEU A  31
GLY A  72
VAL A  73
 None
 0.91A 5i73A-2a0jA:
undetectable		 5i73A-2a0jA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		5 / 10 ALA A  64
THR A  83
MET A  17
VAL A  87
THR A  57
 None
 1.38A 6aogA-2a0jA:
undetectable		 6aogA-2a0jA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2a0j PTS SYSTEM, NITROGEN
REGULATORY IIA
PROTEIN
(Neisseria
meningitidis) 		5 / 10 ALA A  64
THR A  83
MET A  17
VAL A  87
THR A  57
 None
 1.46A 6aogB-2a0jA:
undetectable		 6aogB-2a0jA:
16.08