SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.06A 1cqeA-2a0uA:
0.9		 1cqeA-2a0uA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.06A 1cqeB-2a0uA:
undetectable		 1cqeB-2a0uA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 345
ARG A  61
ARG A  34
ILE A  66
THR A 219
 None
SO4  A 402 (-4.5A)
None
None
None
 1.21A 1d1gB-2a0uA:
undetectable		 1d1gB-2a0uA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ILE A 359
GLY A 196
VAL A 201
SER A 193
GLY A 263
 None
 0.85A 1kiaA-2a0uA:
4.5		 1kiaA-2a0uA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ILE A 359
GLY A 196
VAL A 201
SER A 193
GLY A 263
 None
 0.86A 1nbhB-2a0uA:
3.3		 1nbhB-2a0uA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ILE A 359
GLY A 196
VAL A 201
SER A 193
GLY A 263
 None
 0.89A 1nbiA-2a0uA:
5.2		 1nbiA-2a0uA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ILE A 359
GLY A 196
VAL A 201
SER A 193
GLY A 263
 None
 0.88A 1nbiB-2a0uA:
5.2		 1nbiB-2a0uA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.10A 2aylA-2a0uA:
undetectable		 2aylA-2a0uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.06A 2aylB-2a0uA:
1.2		 2aylB-2a0uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 5 PRO A  64
ALA A  65
ASP A 265
ASP A 347
 None
None
SO4  A 402 ( 4.3A)
None
 1.20A 2nyuB-2a0uA:
3.5		 2nyuB-2a0uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 LEU A  98
ILE A  51
LEU A  30
ILE A  21
VAL A 148
 None
 1.07A 2ygnA-2a0uA:
undetectable		 2ygnA-2a0uA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 8 LEU A  97
SER A 100
ALA A 145
ALA A  71
 None
 1.02A 3ax9B-2a0uA:
undetectable		 3ax9B-2a0uA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 MET A  58
CYH A 185
PRO A 221
 SO4  A 402 (-4.8A)
SO4  A 402 ( 3.9A)
None
 1.23A 3h52C-2a0uA:
undetectable		 3h52C-2a0uA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.06A 3n8wA-2a0uA:
0.3		 3n8wA-2a0uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.05A 3n8zB-2a0uA:
0.0		 3n8zB-2a0uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.08A 3nt1A-2a0uA:
1.1		 3nt1A-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.07A 3nt1B-2a0uA:
undetectable		 3nt1B-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.03A 3pghC-2a0uA:
undetectable		 3pghC-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.02A 3pghD-2a0uA:
undetectable		 3pghD-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 5 TYR A 149
PRO A  64
THR A 187
THR A  17
 None
 1.45A 3q07A-2a0uA:
undetectable		 3q07A-2a0uA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 5 TYR A 149
PRO A  64
THR A 187
THR A  17
 None
 1.45A 3q07B-2a0uA:
undetectable		 3q07B-2a0uA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 4 SER A 100
ASP A  50
ASP A  44
ALA A  77
 None
None
None
SO4  A 403 ( 4.3A)
 1.49A 3uj6A-2a0uA:
3.4		 3uj6A-2a0uA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.04A 4coxA-2a0uA:
undetectable		 4coxA-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.04A 4coxB-2a0uA:
undetectable		 4coxB-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.03A 4coxC-2a0uA:
undetectable		 4coxC-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.04A 4coxD-2a0uA:
undetectable		 4coxD-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 10 ALA A  67
ALA A  71
ALA A  70
VAL A  45
LEU A  30
 None
 1.19A 4j6cB-2a0uA:
undetectable		 4j6cB-2a0uA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ALA A  67
ALA A  71
ALA A  70
VAL A  45
LEU A  30
 None
 1.07A 4j6dA-2a0uA:
undetectable		 4j6dA-2a0uA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ALA A  67
ALA A  71
ALA A  70
VAL A  45
LEU A  30
 None
 1.08A 4j6dB-2a0uA:
undetectable		 4j6dB-2a0uA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ALA A  67
ALA A  71
ALA A  70
VAL A  45
LEU A  30
 None
 1.13A 4jbtA-2a0uA:
undetectable		 4jbtA-2a0uA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 11 ALA A  67
ALA A  71
ALA A  70
VAL A  45
LEU A  30
 None
 1.13A 4jbtB-2a0uA:
undetectable		 4jbtB-2a0uA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 8 LEU A  28
VAL A  45
VAL A 104
ILE A  55
 None
 0.92A 4l4cB-2a0uA:
undetectable		 4l4cB-2a0uA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 7 GLU A 316
GLU A 315
GLU A 321
ARG A 108
 None
None
None
SO4  A 402 (-3.0A)
 1.01A 4mi4B-2a0uA:
undetectable
4mi4C-2a0uA:
undetectable		 4mi4B-2a0uA:
20.32
4mi4C-2a0uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 8 GLU A 316
GLU A 315
GLU A 321
ARG A 108
 None
None
None
SO4  A 402 (-3.0A)
 1.02A 4mj8B-2a0uA:
undetectable
4mj8C-2a0uA:
undetectable		 4mj8B-2a0uA:
19.05
4mj8C-2a0uA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ALA A 189
GLY A 188
THR A 187
ALA A 191
THR A 192
 None
 1.20A 4qvyV-2a0uA:
undetectable
4qvyW-2a0uA:
undetectable		 4qvyV-2a0uA:
21.79
4qvyW-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 11 ALA A 189
GLY A 188
THR A 187
ALA A 191
THR A 192
 None
 1.20A 4qw0H-2a0uA:
undetectable
4qw0I-2a0uA:
undetectable		 4qw0H-2a0uA:
21.79
4qw0I-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 11 ALA A 189
GLY A 188
THR A 187
ALA A 191
THR A 192
 None
 1.19A 4qw0V-2a0uA:
undetectable
4qw0W-2a0uA:
undetectable		 4qw0V-2a0uA:
21.79
4qw0W-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 GLN A 269
TYR A 374
SER A 351
GLN A 382
LEU A 302
 None
 1.26A 4qztA-2a0uA:
undetectable		 4qztA-2a0uA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 THR A 219
GLN A 224
ASP A 265
ALA A 274
ILE A 184
 None
SO4  A 402 (-4.2A)
SO4  A 402 ( 4.3A)
None
None
 1.47A 4rp9A-2a0uA:
undetectable		 4rp9A-2a0uA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.08A 4rrwA-2a0uA:
0.0		 4rrwA-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.10A 4rrwB-2a0uA:
undetectable		 4rrwB-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.08A 4rrwC-2a0uA:
0.0		 4rrwC-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.10A 4rrxA-2a0uA:
undetectable		 4rrxA-2a0uA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.05A 4rrxB-2a0uA:
undetectable		 4rrxB-2a0uA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.08A 4rrzA-2a0uA:
0.0		 4rrzA-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.10A 4rrzB-2a0uA:
undetectable		 4rrzB-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.08A 4rrzC-2a0uA:
0.0		 4rrzC-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 8 ALA A  70
ALA A  71
ILE A  74
ALA A 123
LEU A  97
 None
 1.03A 4v1fA-2a0uA:
undetectable
4v1fB-2a0uA:
undetectable		 4v1fA-2a0uA:
13.90
4v1fB-2a0uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 6 ASP A 152
ALA A  67
THR A 300
THR A 301
 None
 1.46A 4w5tA-2a0uA:
2.6		 4w5tA-2a0uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 6 ASP A 152
ALA A  67
THR A 300
THR A 301
 None
 1.47A 4z4cA-2a0uA:
2.6		 4z4cA-2a0uA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 6 ASP A 152
ALA A  67
THR A 300
THR A 301
 None
 1.47A 4z4iA-2a0uA:
2.6		 4z4iA-2a0uA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 11 ALA A 189
GLY A 188
THR A 187
ALA A 191
THR A 192
 None
 1.19A 5bxnH-2a0uA:
undetectable
5bxnI-2a0uA:
undetectable		 5bxnH-2a0uA:
21.79
5bxnI-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 TRP A 222
ARG A  34
LEU A  36
 None
 0.98A 5dbyA-2a0uA:
undetectable		 5dbyA-2a0uA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.12A 5ikqA-2a0uA:
undetectable		 5ikqA-2a0uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.10A 5ikqB-2a0uA:
undetectable		 5ikqB-2a0uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.12A 5ikrA-2a0uA:
undetectable		 5ikrA-2a0uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.11A 5ikrB-2a0uA:
undetectable		 5ikrB-2a0uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 VAL A 261
HIS A 162
VAL A 364
 None
 0.70A 5jmnC-2a0uA:
undetectable		 5jmnC-2a0uA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.10A 5jvzB-2a0uA:
undetectable		 5jvzB-2a0uA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ALA A 189
GLY A 188
THR A 187
ALA A 191
THR A 192
 None
 1.21A 5l5fH-2a0uA:
undetectable
5l5fI-2a0uA:
undetectable		 5l5fH-2a0uA:
21.79
5l5fI-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 GLN A 224
ALA A 189
GLY A 188
THR A 187
ALA A 191
 SO4  A 402 (-4.2A)
None
None
None
None
 1.20A 5l5fH-2a0uA:
undetectable
5l5fI-2a0uA:
undetectable		 5l5fH-2a0uA:
21.79
5l5fI-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ALA A 189
GLY A 188
THR A 187
ALA A 191
THR A 192
 None
 1.21A 5l5fV-2a0uA:
undetectable
5l5fW-2a0uA:
undetectable		 5l5fV-2a0uA:
21.79
5l5fW-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 GLN A 224
ALA A 189
GLY A 188
THR A 187
ALA A 191
 SO4  A 402 (-4.2A)
None
None
None
None
 1.20A 5l5fV-2a0uA:
undetectable
5l5fW-2a0uA:
undetectable		 5l5fV-2a0uA:
21.79
5l5fW-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 ALA A 189
GLY A 188
THR A 187
ALA A 191
THR A 192
 None
 1.21A 5l66H-2a0uA:
undetectable
5l66I-2a0uA:
undetectable		 5l66H-2a0uA:
21.79
5l66I-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		5 / 12 GLN A 224
ALA A 189
GLY A 188
THR A 187
ALA A 191
 SO4  A 402 (-4.2A)
None
None
None
None
 1.18A 5l66H-2a0uA:
undetectable
5l66I-2a0uA:
undetectable		 5l66H-2a0uA:
21.79
5l66I-2a0uA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 THR A 301
PRO A 298
ASP A 152
 None
 0.92A 5l8dB-2a0uA:
undetectable		 5l8dB-2a0uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 THR A 301
PRO A 298
ASP A 152
 None
 0.92A 5mwuB-2a0uA:
undetectable		 5mwuB-2a0uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 ALA A 216
GLN A 224
THR A 229
 None
SO4  A 402 (-4.2A)
None
 0.75A 5n0oA-2a0uA:
1.8		 5n0oA-2a0uA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		4 / 7 ILE A 354
LEU A 302
THR A 197
THR A 306
 None
 0.95A 5vc0A-2a0uA:
undetectable		 5vc0A-2a0uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 THR A 320
THR A 323
ARG A 331
 None
 0.98A 5wm2A-2a0uA:
3.1		 5wm2A-2a0uA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 LEU A 282
THR A 187
ASN A 186
 None
 0.70A 6baaE-2a0uA:
undetectable		 6baaE-2a0uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 LEU A 282
THR A 187
ASN A 186
 None
 0.70A 6baaF-2a0uA:
0.6		 6baaF-2a0uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 LEU A 282
THR A 187
ASN A 186
 None
 0.71A 6baaG-2a0uA:
0.7		 6baaG-2a0uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2a0u INITIATION FACTOR 2B
(Leishmania
major) 		3 / 3 LEU A 282
THR A 187
ASN A 186
 None
 0.71A 6baaH-2a0uA:
0.6		 6baaH-2a0uA:
13.90