SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  99
LEU A   8
ALA A  11
LEU A  12
 None
 0.70A 1hwiB-2a11A:
undetectable		 1hwiB-2a11A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  99
LEU A   8
ALA A  11
LEU A  12
 None
 0.68A 1hwiD-2a11A:
undetectable		 1hwiD-2a11A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  99
LEU A   8
ALA A  11
LEU A  12
 None
 0.68A 1hwiC-2a11A:
undetectable		 1hwiC-2a11A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  16
LEU A 145
LEU A   8
LEU A  91
LEU A   9
 None
 0.74A 1mx1C-2a11A:
undetectable		 1mx1C-2a11A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  27
THR A 109
GLY A 111
GLY A 103
ASP A 113
 None
 1.29A 1n2xA-2a11A:
undetectable		 1n2xA-2a11A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 103
SER A  29
ILE A 117
HIS A  27
 None
 1.14A 1yajJ-2a11A:
undetectable		 1yajJ-2a11A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 123
GLY A  47
ASN A  40
ASP A  48
ALA A  49
 CA  A1001 (-3.5A)
None
None
CA  A1001 ( 4.7A)
None
 1.22A 2br4B-2a11A:
undetectable		 2br4B-2a11A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  20
ARG A   5
ILE A 129
HIS A 133
GLY A  13
 None
 1.48A 2vufA-2a11A:
0.0		 2vufA-2a11A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 8 PRO A   7
SER A   4
LEU A  21
ASP A  18
 None
 1.13A 3lsfH-2a11A:
undetectable		 3lsfH-2a11A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 121
ALA A 128
ILE A 129
LEU A  12
LEU A   9
 None
 1.19A 4xumB-2a11A:
undetectable		 4xumB-2a11A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 120
HIS A  27
ARG A  28
ILE A 117
 CA  A1001 (-4.3A)
None
None
None
 1.01A 5a06A-2a11A:
undetectable		 5a06A-2a11A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 120
HIS A  27
ARG A  28
ILE A 117
 CA  A1001 (-4.3A)
None
None
None
 1.00A 5a06B-2a11A:
undetectable		 5a06B-2a11A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 120
HIS A  27
ARG A  28
ILE A 117
 CA  A1001 (-4.3A)
None
None
None
 1.00A 5a06D-2a11A:
undetectable		 5a06D-2a11A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 120
HIS A  27
ARG A  28
ILE A 117
 CA  A1001 (-4.3A)
None
None
None
 1.02A 5a06F-2a11A:
undetectable		 5a06F-2a11A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2a11 RIBONUCLEASE III
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 125
GLY A 127
GLY A  47
ALA A  24
 None
 0.78A 5o96C-2a11A:
undetectable		 5o96C-2a11A:
25.95