SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TRP A 107
ARG A 123
THR A 108
 None
 0.93A 1df7A-2a14A:
undetectable		 1df7A-2a14A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ASP A  28
GLY A  29
PRO A  31
SER A  32
 None
 0.92A 1n4fA-2a14A:
undetectable		 1n4fA-2a14A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ASP A  61
LEU A 161
VAL A 160
TYR A  25
 None
None
None
SAH  A4001 (-4.4A)
 1.02A 1s9qA-2a14A:
undetectable		 1s9qA-2a14A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ASP A  61
LEU A 193
LEU A 183
LEU A 161
 None
 1.42A 1u18A-2a14A:
undetectable		 1u18A-2a14A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 183
LEU A 186
LEU A 156
ALA A 157
THR A 162
 None
 1.11A 1ya3C-2a14A:
undetectable		 1ya3C-2a14A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ILE A  68
ASP A  76
LEU A  59
ARG A 132
 None
 1.17A 2a7qA-2a14A:
undetectable		 2a7qA-2a14A:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 12 TYR A  11
GLN A  70
PHE A  86
ASP A 142
VAL A 143
HIS A 144
TYR A 204
 SAH  A4001 ( 3.8A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-4.3A)
None
 0.53A 2g70A-2a14A:
36.9		 2g70A-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A  20
THR A  67
TYR A  25
ASP A  61
 SAH  A4001 (-4.2A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.4A)
None
 0.88A 2g70A-2a14A:
36.9		 2g70A-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 TYR A  20
TYR A  25
GLY A  65
THR A  67
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.2A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.4A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.9A)
 0.31A 2g70A-2a14A:
36.9		 2g70A-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 7 TYR A  69
GLY A  65
THR A  67
ASP A  85
ASN A  90
 SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.9A)
 1.31A 2g70A-2a14A:
36.9		 2g70A-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 12 TYR A  11
GLN A  70
PHE A  86
ASP A 142
VAL A 143
HIS A 144
TYR A 204
 SAH  A4001 ( 3.8A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-4.3A)
None
 0.52A 2g70B-2a14A:
36.8		 2g70B-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A  20
THR A  67
TYR A  25
ASP A  61
 SAH  A4001 (-4.2A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.4A)
None
 0.87A 2g70B-2a14A:
36.8		 2g70B-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 TYR A  20
TYR A  25
GLY A  65
THR A  67
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.2A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.4A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.9A)
 0.32A 2g70B-2a14A:
36.8		 2g70B-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 12 TYR A  11
THR A  67
PHE A  86
ASP A 142
VAL A 143
HIS A 144
TYR A 204
 SAH  A4001 ( 3.8A)
SAH  A4001 (-3.5A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-4.3A)
None
 0.45A 2g72A-2a14A:
36.8		 2g72A-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 6 TYR A  20
TYR A  25
GLY A  65
TYR A  69
ASP A  85
ASN A  90
 SAH  A4001 (-4.2A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.4A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.9A)
 0.25A 2g72A-2a14A:
36.8		 2g72A-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 12 TYR A  11
THR A  67
GLN A  70
PHE A  86
VAL A 143
HIS A 144
TYR A 204
 SAH  A4001 ( 3.8A)
SAH  A4001 (-3.5A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.7A)
SAH  A4001 (-4.3A)
None
 0.47A 2g72B-2a14A:
36.8		 2g72B-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 7 TYR A  20
TYR A  25
GLY A  65
TYR A  69
ASP A  85
ASN A  90
ASP A 142
 SAH  A4001 (-4.2A)
SAH  A4001 (-4.4A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.4A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.9A)
SAH  A4001 (-3.7A)
 0.30A 2g72B-2a14A:
36.8		 2g72B-2a14A:
35.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A  24
ASP A  85
ASN A  90
ASP A 142
 None
SAH  A4001 (-2.7A)
SAH  A4001 (-3.9A)
SAH  A4001 (-3.7A)
 1.08A 2g72B-2a14A:
36.8		 2g72B-2a14A:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  38
ILE A  68
ALA A 110
LEU A 163
TYR A  25
 None
None
None
SAH  A4001 (-4.5A)
SAH  A4001 (-4.4A)
 1.21A 2japA-2a14A:
6.0		 2japA-2a14A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  42
ILE A  68
VAL A 111
ALA A 114
LEU A 163
 None
None
None
None
SAH  A4001 (-4.5A)
 1.21A 2japA-2a14A:
6.0		 2japA-2a14A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  42
ILE A  68
VAL A 111
ALA A 114
LEU A 163
 None
None
None
None
SAH  A4001 (-4.5A)
 1.21A 2japB-2a14A:
6.3		 2japB-2a14A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  38
ILE A  68
ALA A 110
LEU A 163
TYR A  25
 None
None
None
SAH  A4001 (-4.5A)
SAH  A4001 (-4.4A)
 1.19A 2japC-2a14A:
6.0		 2japC-2a14A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  42
ILE A  68
VAL A 111
ALA A 114
LEU A 163
 None
None
None
None
SAH  A4001 (-4.5A)
 1.21A 2japD-2a14A:
6.0		 2japD-2a14A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 THR A  67
ASP A  85
THR A  87
ASP A 142
 SAH  A4001 (-3.5A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
 0.86A 2okcB-2a14A:
9.8		 2okcB-2a14A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 TYR A  20
GLY A  63
GLY A  65
ASP A 142
VAL A 143
TYR A  11
 SAH  A4001 (-4.2A)
SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 ( 3.8A)
 1.35A 2qe6A-2a14A:
14.0		 2qe6A-2a14A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 TYR A  25
GLY A  63
GLY A  65
ASP A 142
VAL A 143
HIS A 144
 SAH  A4001 (-4.4A)
SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-4.3A)
 1.38A 3dlcA-2a14A:
13.5		 3dlcA-2a14A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A  69
GLY A  63
GLY A  65
ASP A 142
HIS A 144
 SAH  A4001 (-4.4A)
SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 (-3.7A)
SAH  A4001 (-4.3A)
 0.98A 3dlcA-2a14A:
13.5		 3dlcA-2a14A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  63
GLY A  65
GLN A  70
PHE A  86
ALA A 165
 SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.4A)
 0.74A 3kkzA-2a14A:
13.7		 3kkzA-2a14A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  63
GLY A  65
GLN A  70
PHE A  86
ALA A 165
 SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.4A)
 0.68A 3kkzB-2a14A:
14.4		 3kkzB-2a14A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TYR A  20
ASP A  85
ASP A 142
 SAH  A4001 (-4.2A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.7A)
 0.31A 3ou6B-2a14A:
17.0		 3ou6B-2a14A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TYR A  20
GLY A  65
ASP A  85
 SAH  A4001 (-4.2A)
SAH  A4001 (-3.0A)
SAH  A4001 (-2.7A)
 0.27A 3ou6C-2a14A:
17.1		 3ou6C-2a14A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A  65
ASP A  85
ASP A 142
 SAH  A4001 (-3.0A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.7A)
 0.41A 3ou7C-2a14A:
17.1		 3ou7C-2a14A:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 8 TYR A  20
LEU A 164
TYR A 204
TYR A 242
 SAH  A4001 (-4.2A)
SAH  A4001 (-4.3A)
None
None
 0.43A 3rodA-2a14A:
43.2		 3rodA-2a14A:
48.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 9 TYR A  20
TYR A  24
LEU A 164
TYR A 204
TYR A 242
 SAH  A4001 (-4.2A)
None
SAH  A4001 (-4.3A)
None
None
 0.44A 3rodB-2a14A:
43.1		 3rodB-2a14A:
48.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 TYR A  20
TYR A  24
LEU A 164
TYR A 204
TYR A 242
 SAH  A4001 (-4.2A)
None
SAH  A4001 (-4.3A)
None
None
 0.48A 3rodC-2a14A:
42.3		 3rodC-2a14A:
48.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A  20
LEU A 164
TYR A 204
TYR A 242
 SAH  A4001 (-4.2A)
SAH  A4001 (-4.3A)
None
None
 0.53A 3rodD-2a14A:
42.5		 3rodD-2a14A:
48.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 GLY A  63
GLY A  65
GLN A  70
ASP A  85
PHE A  86
ALA A 165
 SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-2.7A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.4A)
 0.62A 3t7sA-2a14A:
14.5		 3t7sA-2a14A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 GLY A  63
GLY A  65
GLN A  70
ASP A  85
PHE A  86
ALA A 165
 SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-2.7A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.4A)
 0.58A 3t7sB-2a14A:
14.9		 3t7sB-2a14A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 GLY A  63
GLY A  65
GLN A  70
ASP A  85
PHE A  86
ALA A 165
 SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 ( 4.4A)
SAH  A4001 (-2.7A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.4A)
 0.58A 3t7sD-2a14A:
14.5		 3t7sD-2a14A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 186
LEU A 183
LEU A 180
ALA A 179
ALA A 165
 None
None
None
None
SAH  A4001 (-3.4A)
 1.00A 4fn9A-2a14A:
undetectable		 4fn9A-2a14A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 183
LEU A 186
LEU A 156
ALA A 157
THR A 162
 None
 1.13A 4fn9B-2a14A:
undetectable		 4fn9B-2a14A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  63
GLY A  65
ASP A  85
ASP A 142
ALA A 165
 SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.4A)
 0.69A 4iv8A-2a14A:
15.5		 4iv8A-2a14A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A  63
GLY A  65
ASP A  85
ASP A 142
ALA A 165
 SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.7A)
SAH  A4001 (-3.4A)
 0.70A 4iv8B-2a14A:
15.5		 4iv8B-2a14A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 SER A 172
LEU A 173
ASP A 174
LEU A 216
 None
 0.99A 4wozA-2a14A:
undetectable
4wozB-2a14A:
undetectable		 4wozA-2a14A:
21.73
4wozB-2a14A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ASP A  61
GLY A  65
ASP A  85
ASP A 142
 None
SAH  A4001 (-3.0A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.7A)
 0.71A 5e72A-2a14A:
13.4		 5e72A-2a14A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 GLY A  63
GLY A  65
PHE A  86
ASP A 142
 SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
SAH  A4001 (-4.6A)
SAH  A4001 (-3.7A)
 0.52A 5ergB-2a14A:
11.5		 5ergB-2a14A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ALA A 179
ASN A 182
LEU A 183
 None
 0.37A 5i1nB-2a14A:
undetectable		 5i1nB-2a14A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ALA A 179
ASN A 182
LEU A 183
 None
 0.42A 5i1oA-2a14A:
undetectable		 5i1oA-2a14A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 ILE A  62
GLY A  63
GLY A  65
VAL A 138
LEU A 139
 None
SAH  A4001 (-3.9A)
SAH  A4001 (-3.0A)
None
None
 0.94A 5o96C-2a14A:
undetectable
5o96D-2a14A:
undetectable		 5o96C-2a14A:
21.74
5o96D-2a14A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 193
GLY A 190
LEU A 183
LEU A 186
VAL A 160
 None
 1.00A 5twjA-2a14A:
undetectable		 5twjA-2a14A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 10 LEU A 193
GLY A 190
LEU A 183
LEU A 186
VAL A 160
 None
 1.02A 5twjB-2a14A:
undetectable		 5twjB-2a14A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 8 ALA A 165
THR A 162
THR A 195
ALA A 184
 SAH  A4001 (-3.4A)
None
None
None
 1.01A 5x2tI-2a14A:
undetectable
5x2tJ-2a14A:
undetectable
5x2tK-2a14A:
undetectable
5x2tL-2a14A:
undetectable		 5x2tI-2a14A:
20.16
5x2tJ-2a14A:
19.16
5x2tK-2a14A:
20.16
5x2tL-2a14A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 VAL A 225
LEU A  45
ALA A 257
LEU A  54
LEU A 187
 None
 1.04A 6ew0B-2a14A:
undetectable		 6ew0B-2a14A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 VAL A 225
LEU A  45
ALA A 257
LEU A  54
LEU A 187
 None
 1.04A 6ew0D-2a14A:
undetectable		 6ew0D-2a14A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 VAL A 225
LEU A  45
ALA A 257
LEU A  54
LEU A 187
 None
 1.05A 6ew0H-2a14A:
2.5		 6ew0H-2a14A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 VAL A 225
LEU A  45
ALA A 257
LEU A  54
LEU A 187
 None
 1.04A 6ew0I-2a14A:
2.5		 6ew0I-2a14A:
14.45