SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a19'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2a19 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 139
ALA A 140
PHE A 137
GLY A 138
 None
 1.26A 1mj2B-2a19A:
undetectable		 1mj2B-2a19A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2a19 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 139
ALA A 140
PHE A 137
GLY A 138
 None
 1.28A 1mj2D-2a19A:
undetectable		 1mj2D-2a19A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2a19 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 139
ALA A 140
PHE A 137
GLY A 138
 None
 1.26A 1mjoB-2a19A:
undetectable		 1mjoB-2a19A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2a19 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 139
ALA A 140
PHE A 137
GLY A 138
 None
 1.27A 1mjoD-2a19A:
undetectable		 1mjoD-2a19A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2a19 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 MET A  29
VAL A  64
GLU A  42
 None
 0.92A 2x9gA-2a19A:
undetectable		 2x9gA-2a19A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2a19 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 129
ILE A 110
PHE A 144
LEU A 133
CYH A 114
 None
 0.96A 3dzuA-2a19A:
undetectable		 3dzuA-2a19A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2a19 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 129
ILE A 110
PHE A 144
LEU A 133
CYH A 114
 None
 1.01A 6a5zD-2a19A:
undetectable		 6a5zD-2a19A:
18.24