SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		5 / 10 LEU A 194
VAL A 196
ILE A 190
PHE A 202
THR A 234
 None
 1.12A 2w9hA-2a1fA:
undetectable		 2w9hA-2a1fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		4 / 4 LEU A  52
ARG A  33
LEU A  31
ALA A  17
 None
 1.03A 3b9mA-2a1fA:
undetectable		 3b9mA-2a1fA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		5 / 12 LEU A  18
GLY A  53
GLY A  15
ALA A  80
THR A  81
 None
 1.11A 3dh0B-2a1fA:
3.8		 3dh0B-2a1fA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		3 / 3 THR A 135
GLU A 152
HIS A 208
 None
 0.69A 3g1uB-2a1fA:
3.2		 3g1uB-2a1fA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		3 / 3 GLU A 232
GLY A 229
THR A 228
 None
 0.41A 3iazA-2a1fA:
undetectable		 3iazA-2a1fA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		4 / 7 GLY A  54
ASN A  84
GLY A 134
THR A 135
 None
 0.68A 3tajA-2a1fA:
undetectable		 3tajA-2a1fA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		4 / 6 LEU A  52
LEU A  18
ILE A  30
MET A  34
 None
 1.00A 4do3B-2a1fA:
undetectable		 4do3B-2a1fA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		5 / 11 LEU A  86
VAL A  82
LEU A  18
GLY A  53
LEU A  57
 None
 1.32A 4zbqA-2a1fA:
undetectable		 4zbqA-2a1fA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		3 / 3 VAL A  82
GLN A 106
CYH A 111
 None
 0.83A 5icxC-2a1fA:
undetectable
5icxF-2a1fA:
undetectable		 5icxC-2a1fA:
20.30
5icxF-2a1fA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		3 / 3 ILE A   9
VAL A 227
PRO A   4
 None
 0.62A 5uunA-2a1fA:
undetectable		 5uunA-2a1fA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2a1f URIDYLATE KINASE
(Haemophilus
influenzae) 		3 / 3 ALA A 155
VAL A 227
TYR A   6
 None
 0.66A 5zmqH-2a1fA:
undetectable		 5zmqH-2a1fA:
22.18