SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_B_TA1B502_1 (TUBULIN BETA CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.24A	3j6gB-2a1jB: undetectable	3j6gB-2a1jB: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_D_TA1D502_1 (TUBULIN BETA CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.24A	3j6gD-2a1jB: undetectable	3j6gD-2a1jB: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_F_TA1F502_1 (TUBULIN BETA CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.24A	3j6gF-2a1jB: undetectable	3j6gF-2a1jB: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_H_TA1H502_1 (TUBULIN BETA CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.24A	3j6gH-2a1jB: undetectable	3j6gH-2a1jB: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_J_TA1J502_1 (TUBULIN BETA CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.24A	3j6gJ-2a1jB: undetectable	3j6gJ-2a1jB: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_L_TA1L502_1 (TUBULIN BETA CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.24A	3j6gL-2a1jB: undetectable	3j6gL-2a1jB: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_N_TA1N502_1 (TUBULIN BETA CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.24A	3j6gN-2a1jB: undetectable	3j6gN-2a1jB: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_P_TA1P502_1 (TUBULIN BETA CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.24A	3j6gP-2a1jB: undetectable	3j6gP-2a1jB: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_R_TA1R502_1 (TUBULIN BETA CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.25A	3j6gR-2a1jB: undetectable	3j6gR-2a1jB: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O1E_A_C2FA3000_1 (DIHYDROPTEROATE SYNTHASE DHPS)	2a1j	DNA REPAIR ENDONUCLEASE XPF (Homo sapiens)	3 / 3	LYS A 884 ASN A 851 ASP A 888	None	0.87A	4o1eA-2a1jA: undetectable	4o1eA-2a1jA: 11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z90_F_4LEF402_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	4 / 7	LEU B 285 LEU B 271 ALA B 266 LEU B 239	None	0.48A	4z90F-2a1jB: undetectable 4z90G-2a1jB: undetectable 4z90H-2a1jB: undetectable 4z90J-2a1jB: undetectable	4z90F-2a1jB: 12.10 4z90G-2a1jB: 12.10 4z90H-2a1jB: 12.10 4z90J-2a1jB: 12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M5C_B_TA1B502_1 (TUBULIN BETA-2B CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 12	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.20A	5m5cB-2a1jB: undetectable	5m5cB-2a1jB: 12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M5C_E_TA1E502_1 (TUBULIN BETA-2B CHAIN)	2a1j	DNA EXCISION REPAIR PROTEIN ERCC-1 (Homo sapiens)	5 / 10	VAL B 288 ASP B 287 LEU B 260 THR B 256 LEU B 277	None None None None HG B 1 ( 3.8A)	1.20A	5m5cE-2a1jB: undetectable	5m5cE-2a1jB: 12.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3J6G_B_TA1B502_1","TUBULIN BETA CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.24A","3j6gB-2a1jB:undetectable","3j6gB-2a1jB:12.86"],["3J6G_D_TA1D502_1","TUBULIN BETA CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.24A","3j6gD-2a1jB:undetectable","3j6gD-2a1jB:12.86"],["3J6G_F_TA1F502_1","TUBULIN BETA CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.24A","3j6gF-2a1jB:undetectable","3j6gF-2a1jB:12.86"],["3J6G_H_TA1H502_1","TUBULIN BETA CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.24A","3j6gH-2a1jB:undetectable","3j6gH-2a1jB:12.86"],["3J6G_J_TA1J502_1","TUBULIN BETA CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.24A","3j6gJ-2a1jB:undetectable","3j6gJ-2a1jB:12.86"],["3J6G_L_TA1L502_1","TUBULIN BETA CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.24A","3j6gL-2a1jB:undetectable","3j6gL-2a1jB:12.86"],["3J6G_N_TA1N502_1","TUBULIN BETA CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.24A","3j6gN-2a1jB:undetectable","3j6gN-2a1jB:12.86"],["3J6G_P_TA1P502_1","TUBULIN BETA CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.24A","3j6gP-2a1jB:undetectable","3j6gP-2a1jB:12.86"],["3J6G_R_TA1R502_1","TUBULIN BETA CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.25A","3j6gR-2a1jB:undetectable","3j6gR-2a1jB:12.86"],["4O1E_A_C2FA3000_1","DIHYDROPTEROATE SYNTHASE DHPS","2a1j","DNA REPAIR ENDONUCLEASE XPF","Homo sapiens",3,"LYS A 884;ASN A 851;ASP A 888","None","0.87A","4o1eA-2a1jA:undetectable","4o1eA-2a1jA:11.47"],["4Z90_F_4LEF402_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1;GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",4,"LEU B 285;LEU B 271;ALA B 266;LEU B 239","None","0.48A","4z90F-2a1jB:undetectable;4z90G-2a1jB:undetectable;4z90H-2a1jB:undetectable;4z90J-2a1jB:undetectable","4z90F-2a1jB:12.10;4z90G-2a1jB:12.10;4z90H-2a1jB:12.10;4z90J-2a1jB:12.10"],["5M5C_B_TA1B502_1","TUBULIN BETA-2B CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.20A","5m5cB-2a1jB:undetectable","5m5cB-2a1jB:12.65"],["5M5C_E_TA1E502_1","TUBULIN BETA-2B CHAIN","2a1j","DNA EXCISION REPAIR PROTEIN ERCC-1","Homo sapiens",5,"VAL B 288;ASP B 287;LEU B 260;THR B 256;LEU B 277","None;None;None;None; HG B   1 ( 3.8A)","1.20A","5m5cE-2a1jB:undetectable","5m5cE-2a1jB:12.65"]]