SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		5 / 12 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.88A 1cqeA-2a1rA:
undetectable		 1cqeA-2a1rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		5 / 12 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.88A 1cqeB-2a1rA:
undetectable		 1cqeB-2a1rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		5 / 9 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.95A 1eqgA-2a1rA:
undetectable		 1eqgA-2a1rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		5 / 11 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.97A 1eqgB-2a1rA:
undetectable		 1eqgB-2a1rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		5 / 12 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.93A 1eqhA-2a1rA:
undetectable		 1eqhA-2a1rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		5 / 12 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.94A 1eqhB-2a1rA:
undetectable		 1eqhB-2a1rA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		4 / 5 ALA A 383
TYR A 384
ALA A 379
TYR A 381
 None
 1.09A 1xl6A-2a1rA:
undetectable
1xl6B-2a1rA:
undetectable		 1xl6A-2a1rA:
19.87
1xl6B-2a1rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		5 / 12 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.93A 2aylB-2a1rA:
undetectable		 2aylB-2a1rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		4 / 4 ALA A 383
TYR A 384
ALA A 379
TYR A 381
 None
 1.11A 2wlkA-2a1rA:
undetectable
2wlkB-2a1rA:
undetectable		 2wlkA-2a1rA:
19.87
2wlkB-2a1rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		5 / 12 VAL A 284
LEU A 322
ILE A 274
ALA A 278
SER A 280
 None
 0.96A 3kk6A-2a1rA:
undetectable		 3kk6A-2a1rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		4 / 8 PHE A 400
GLY A 398
ILE A 337
PHE A 418
 None
 0.78A 3ko0O-2a1rA:
undetectable
3ko0Q-2a1rA:
undetectable		 3ko0O-2a1rA:
13.08
3ko0Q-2a1rA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		4 / 7 VAL A 284
VAL A 293
ASP A 324
MET A 328
 None
 0.87A 3rgfA-2a1rA:
undetectable		 3rgfA-2a1rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		4 / 8 MET A 328
ALA A 329
VAL A 360
PHE A  74
 None
 1.00A 4ltwA-2a1rA:
undetectable		 4ltwA-2a1rA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		4 / 7 ILE A  34
GLY A  33
PHE A 300
PHE A  69
 A  C 502 ( 4.1A)
A  C 503 ( 3.8A)
None
None
 1.09A 5hieA-2a1rA:
undetectable		 5hieA-2a1rA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		5 / 12 TYR A  54
VAL A 284
LEU A 290
PHE A  69
VAL A 297
 None
 1.26A 6a93B-2a1rA:
undetectable		 6a93B-2a1rA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens) 		4 / 7 PHE A  88
LEU A  71
ALA A  18
GLN A  68
 None
 1.16A 6b89A-2a1rA:
undetectable		 6b89A-2a1rA:
13.59