SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Homo
sapiens) 		3 / 3 GLN B  72
HIS B  88
PRO B  68
 None
 0.88A 1d8cA-2a1uB:
undetectable		 1d8cA-2a1uB:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Homo
sapiens) 		4 / 8 GLU B  48
LEU B 160
ALA B 179
LEU B 177
 None
 0.92A 1hwiB-2a1uB:
undetectable		 1hwiB-2a1uB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Homo
sapiens) 		4 / 8 GLU B  48
LEU B 160
ALA B 179
LEU B 177
 None
 0.91A 1hwiD-2a1uB:
undetectable		 1hwiD-2a1uB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Homo
sapiens) 		4 / 8 GLU B  48
LEU B 160
ALA B 179
LEU B 177
 None
 0.92A 1hwiC-2a1uB:
undetectable		 1hwiC-2a1uB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Homo
sapiens) 		5 / 12 LEU B 102
LEU B 108
ALA B 109
LEU B 142
VAL B 180
 None
 1.11A 1s9pB-2a1uB:
undetectable		 1s9pB-2a1uB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2a1u ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Homo
sapiens) 		3 / 3 LEU B 222
GLY B 100
PHE B 141
 None
 0.58A 6exiC-2a1uB:
undetectable		 6exiC-2a1uB:
17.39