SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2a1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 12 MET A 101
HIS A 175
ASP A 177
LEU A 206
HIS A 264
 None
FE2  A 450 ( 3.3A)
FE2  A 450 ( 2.8A)
None
FE2  A 450 ( 3.4A)
 1.43A 1uobA-2a1xA:
10.6		 1uobA-2a1xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		4 / 8 TYR A  46
ASP A 187
TYR A  61
HIS A 281
 None
 1.47A 2ha2A-2a1xA:
undetectable		 2ha2A-2a1xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		4 / 8 TYR A  46
ASP A 187
TYR A  61
HIS A 281
 None
 1.47A 2ha2B-2a1xA:
undetectable		 2ha2B-2a1xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		3 / 3 HIS A 264
ILE A 236
LEU A 217
 FE2  A 450 ( 3.4A)
None
None
 0.69A 2kceA-2a1xA:
undetectable		 2kceA-2a1xA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		4 / 5 LEU A 206
ALA A 277
ILE A 159
SER A 279
 None
AKG  A 451 ( 4.5A)
AKG  A 451 (-3.5A)
None
 1.13A 2othA-2a1xA:
undetectable		 2othA-2a1xA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 11 HIS A 281
ASP A 177
HIS A 175
SER A 266
LEU A 206
 None
FE2  A 450 ( 2.8A)
FE2  A 450 ( 3.3A)
AKG  A 451 (-2.6A)
None
 1.25A 2q0jB-2a1xA:
undetectable		 2q0jB-2a1xA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		4 / 6 PHE A 124
TYR A 133
CYH A 280
VAL A 331
 None
 1.38A 3ltwA-2a1xA:
undetectable		 3ltwA-2a1xA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 12 PHE A  81
LEU A 140
VAL A 143
PHE A 282
VAL A 331
 None
 1.35A 3u9fB-2a1xA:
undetectable
3u9fC-2a1xA:
undetectable		 3u9fB-2a1xA:
20.39
3u9fC-2a1xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 10 PHE A  81
LEU A 140
VAL A 143
PHE A 282
VAL A 331
 None
 1.34A 3u9fE-2a1xA:
undetectable		 3u9fE-2a1xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 12 PHE A  81
LEU A 140
VAL A 143
PHE A 282
VAL A 331
 None
 1.38A 3u9fH-2a1xA:
undetectable
3u9fI-2a1xA:
undetectable		 3u9fH-2a1xA:
20.39
3u9fI-2a1xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 12 PHE A  81
LEU A 140
VAL A 143
PHE A 282
VAL A 331
 None
 1.33A 3u9fJ-2a1xA:
undetectable
3u9fK-2a1xA:
undetectable		 3u9fJ-2a1xA:
20.39
3u9fK-2a1xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 10 PHE A  81
LEU A 140
VAL A 143
PHE A 282
VAL A 331
 None
 1.39A 3u9fK-2a1xA:
undetectable		 3u9fK-2a1xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 10 PHE A  81
LEU A 140
VAL A 143
PHE A 282
VAL A 331
 None
 1.41A 3u9fR-2a1xA:
undetectable		 3u9fR-2a1xA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 12 LEU A 206
GLY A 265
ARG A 275
MET A 157
ILE A 236
 None
None
AKG  A 451 (-3.2A)
AKG  A 451 (-3.3A)
None
 1.39A 4oktA-2a1xA:
undetectable		 4oktA-2a1xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		5 / 12 MET A 250
LEU A  67
PHE A  66
TYR A 133
THR A 194
 None
 1.19A 5k9dA-2a1xA:
undetectable		 5k9dA-2a1xA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		4 / 7 LEU A 174
ILE A 199
MET A 250
TRP A 193
 None
None
None
AKG  A 451 (-3.9A)
 1.28A 5ljcA-2a1xA:
undetectable		 5ljcA-2a1xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		4 / 7 LEU A 209
ILE A 199
MET A 250
TRP A 193
 None
None
None
AKG  A 451 (-3.9A)
 1.27A 5ljcA-2a1xA:
undetectable		 5ljcA-2a1xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		3 / 3 ARG A 184
PHE A 282
LEU A 338
 None
 0.87A 5veuA-2a1xA:
undetectable		 5veuA-2a1xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens) 		3 / 3 SER A 186
HIS A 259
TYR A  46
 None
 1.04A 5y2tA-2a1xA:
undetectable		 5y2tA-2a1xA:
undetectable